TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: PBNA    
Lead, Nails

Useful For Suggests clinical disorders or settings where the test may be helpful

Detecting lead exposure using nail specimens

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Nail analysis of lead can be used to corroborate blood analysis.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

<4.0 mcg/g of nails

Reference values apply to all ages.

Interpretation Provides information to assist in interpretation of the test results

Normally, the nail lead content is below 4.0 mcg/g. While nail lead content above 10.0 mcg/g may indicate significant lead exposure, nails are also subject to potential external contamination with environmental lead. Ultimately, the nail lead content needs to be interpreted in addition to the overall clinical scenario including symptoms, physical findings, and other diagnostic results when determining further actions.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Blood lead analysis has the strongest correlation with toxicity.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Strumylaite L, Ryselis S, Kregzdyte R: Content of lead in human hair from people exposed to lead. Int J Hyg Environ Health. 2004;207:345-351

2. Barbosa F, Tanus-Santos J, Gerlach R, Parsons P: A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needs. Environ Health Perspect. 2005;113:1669-1674

3. Sanna E, Liguori A, Palmes L, et al: Blood and hair lead levels in boys and girls living in two Sardinian towns at different risks of lead pollution. Ecotoxicol Environ Saf. 2003;500:293-299

4. Strathmann FG, Blum LM: Toxic elements. In: Nader R, Horwath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018:chap 42

Special Instructions Library of PDFs including pertinent information and forms related to the test