Test Catalog

Test ID: SPNEU    
Streptococcus pneumoniae Antigen, Random, Urine

Useful For Suggests clinical disorders or settings where the test may be helpful

Rapid diagnosis of pneumococcal pneumonia

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Streptococcus pneumoniae is the most frequently encountered bacterial agent of community-acquired pneumonia (CAP). Because of the significant morbidity and mortality associated with pneumococcal pneumonia, septicemia, and meningitis, it is important to have diagnostic test methods available that can provide a rapid diagnosis. In instances where empirical antibiotics are provided for CAP without culture confirmation of S pneumoniae, antigen testing may be useful.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.


Interpretation Provides information to assist in interpretation of the test results

A positive result is indicative of pneumococcal pneumonia.


Negative for pneumococcal pneumonia, suggesting no current or recent pneumococcal infection. Infection due to Streptococcus pneumoniae cannot be ruled out since the antigen present in the sample may be below the detection limit of the test.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

A negative result does not exclude Streptococcus pneumoniae infection.


A diagnosis of S pneumoniae infection must take into consideration all test results, culture results, and the clinical presentation of the patient.


S pneumoniae vaccine may cause false-positive results, especially in patients who have received the vaccine within 5 days of having the test performed.


This assay has not been validated for use with body fluids other than urine or cerebrospinal fluid.


The performance of this assay in patients who have received antibiotics for more than 24 hours has not been established.


The accuracy of this assay has not been proven in small children.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Plouffe JF, Moore SK, Davis R, Facklam RR: Serotypes of Streptococcus pneumoniae blood culture isolates from adults in Franklin County, Ohio. J Clin Microbiol. 1994 Jun;32(6):1606-1607

2. Johnston RB Jr: Pathogenesis of pneumococcal pneumonia. Rev Infect Dis. 1991 May-Jun;13 Suppl 6:S509-S517. doi: 10.1093/clinids/13.supplement_6.s509

3. Janoff EN, Musher DM: Streptococcus pneumoniae. In Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:2473-2491