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Test Catalog

Test ID: UPII    
Uroplakin II Immunostain, Technical Component Only

Useful For Suggests clinical disorders or settings where the test may be helpful

Characterization of urothelial carcinoma

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Uroplakin II (UPII) is a cell membrane protein that forms urothelial plaques on the surface of each urothelial cell and is expressed in the cytoplasm. UPII expression is used in the differentiation between urothelial carcinoma from secondary malignancies involving the urinary tract. UPII also aids in the identification of urothelial origin.

Interpretation Provides information to assist in interpretation of the test results

This test does not include pathologist interpretation, only technical performance of the stain. If interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.

 

The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request; call 855-516-8404.

 

Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen dependent. Best practice is for paraffin sections to be cut within 6 weeks.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Borhan WM, Cimino-Mathews AM, Montgomery EA, Epstein JI: Immunohistochemical Differentiation of Plasmacytoid Urothelial Carcinoma From Secondary Carcinoma Involvement of the Bladder. Am J Surg Pathol. 2017 Nov;41(11):1570-1575

2. Leivo MZ, Elson PJ, Tacha DE, Delahunt B, Hansel DE: A combination of p40, GATA-3 and uroplakin II shows utility in the diagnosis and prognosis of muscle-invasive urothelial carcinoma. Pathol. 2016 Oct;48(6):543-549

3. Tian W, Guner G, Miyamoto H, et al: Utility of uroplakin II expression as a marker of urothelial carcinoma. Hum Pathol. 2015 Jan;46(1):58-64