TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: 8AINH    
Factor VIII Inhibitor Profile, Professional Interpretation

Useful For Suggests clinical disorders or settings where the test may be helpful

Interpretation for the detection of the presence and titer of a specific factor inhibitor directed against coagulation factor VIII

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Factor VIII (FVIII) inhibitors are IgG antibodies directed against coagulation FVIII that typically result in development of potentially life-threatening hemorrhage. These antibodies may develop in 1 of 4 different patient populations:

-Patients with congenital FVIII deficiency (hemophilia A) in response to therapeutic infusions of factor VIII concentrate

-Elderly non-hemophiliac patients (not previously factor VIII deficient)

-Women in postpartum period

-Patients with other autoimmune illnesses

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Only orderable as a reflex. For more information see 8INHE / Factor VIII Inhibitor Evaluation, Plasma.

 

An interpretive report will be provided.

Interpretation Provides information to assist in interpretation of the test results

An interpretive report will be provided when testing is complete.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Kasper CK: Treatment of factor VIII inhibitors. Prog Hemost Thromb 1989;9:57-86

2. Peerschke EI, Castellone DD, Ledford-Kraemer M, et al: Laboratory assessment of FVIII inhibitor titer. Am J Clin Pathol 2009;131(4):552-558

3. Pruthi RK, Nichols WL: Autoimmune factor VIII inhibitors. Curr Opin Hematol 1999;6(5):314-322

4. Laboratory Hematology Practice. Edited by K Kottke-Marchant. Wiley Blackwell Publishing, 2012