Test Catalog

Test ID: INSM1    
Insulinoma-Associated Protein 1 (INSM1), Immunostain, Technical Component Only

Useful For Suggests clinical disorders or settings where the test may be helpful

Aiding in the identification of neuroendocrine tumors

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Insulinoma-associated protein 1 (INSM1) is a transcription factor that plays a role in neurogenesis and neuroendocrine (NE) cell differentiation. INSM1 expression is useful in the diagnosis of NE tumors and has been shown to be more sensitive and specific compared to other NE markers.

Interpretation Provides information to assist in interpretation of the test results

This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.

 

The positive and negative controls are verified as showing appropriate immunoreactivity. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request; contact 855-516-8404.

 

Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Fujino K, Yasufuku K, Kudoh S, et al: INSM1 is the best marker for the diagnosis of neuroendocrine tumors: comparison with CGA, SYP and CD56. Int J Clin Exp Pathol 2017 Jan;10(5):5393-5405

2. Rosenbaum J, Guo Z, Baus R, et al: INSM1: A Novel Immunohistochemical and Molecular Marker for Neuroendocrine and Neuroepithelial Neoplasms. Am J Clin Pathol 2015 Oct;144(4):579-591

3. Rooper L, Sharma R, Li Q, et al: INSM1 Demonstrates Superior Performance to the Individual and Combined Use of Synaptophysin, Chromogranin and CD56 for Diagnosing Neuroendocrine Tumors of the Thoracic Cavity. Am J Surg Pathol 2017 Nov;41(11):1561-1569

4. Lan M, Breslin M: Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation. FASEB J 2018 Jan;23(7):2024-2033