PGKC - Overview: Phosphoglycerate Kinase Enzyme Activity, Blood
Evaluation of individuals with Coombs-negative nonspherocytic hemolytic anemia, especially if X-linked inheritance pattern. Evaluation of individuals with myopathic or neurologic symptoms
IGD - Overview: Immunoglobulin D (IgD), Serum
Providing information on the humoral immune status Identifying an IgD monoclonal gammopathy
NEFA - Overview: Free Fatty Acids, Total, Serum
Evaluation of metabolic status of patients with endocrinopathies Monitoring of control of diabetes mellitus Monitoring the effects of therapeutic diet/exercise lifestyle changes
ADULT - Overview: Adulterants Survey, Random, Urine
Assessment of possible adulteration of a urine specimen submitted for drug of abuse testing Providing the creatinine concentration for normalization purposes
HCO3 - Overview: Bicarbonate, Serum
Diagnosis and treatment of acid-base imbalance in respiratory and metabolic systems
BILID - Overview: Bilirubin Direct, Serum
Evaluation of jaundice and liver functions
METR1 - Overview: Cytochrome b5 Reductase Enzyme Activity, Blood
Evaluation of patients with cyanosis Confirming cases of suspected cytochrome b5 reductase (methemoglobin reductase) deficiency Functional studies in families with cytochrome b5 reductase deficiency
CCTR - Overview: Calcium/Creatinine Ratio, Random, Urine
Calculation of calcium concentration per creatinine concentration
PGK1 - Overview: Phosphoglycerate Kinase Enzyme Activity, Blood
Evaluation of individuals with Coombs-negative nonspherocytic hemolytic anemia, especially if X-linked inheritance pattern Evaluation of individuals with myopathic or neurologic symptoms
RATO2 - Overview: Protein/Creatinine, Random, Urine
Calculation of total protein concentration per creatinine concentration
Providing a genetic evaluation for patients with a personal or family history suggestive of hereditary hemorrhagic telangiectasia (HHT), cerebral cavernous malformation (CCM), capillary malformation-arteriovenous malformation syndrome...
HCHLG - Overview: Hypercholesterolemia Gene Panel, Varies
Providing a genetic evaluation for patients with a personal or family history suggestive of familial hypercholesterolemia (FH), sitosterolemia, or other monogenic forms of inherited hypercholesterolemia Establishing a diagnosis of FH,...
RPDE - Overview: Rapidly Progressive Dementia Evaluation, Spinal Fluid
Evaluation of individuals presenting with rapidly progressive dementia of uncertain disease etiology and a differential diagnosis of Creutzfeldt-Jakob disease and rapidly progressive Alzheimer disease
TRECS - Overview: T-Cell Receptor Excision Circles Analysis, Blood
Measuring T-cell output or reconstitution (thymopoiesis) following hematopoietic cell transplantation or highly active antiretroviral therapy Evaluating thymic function in patients with cellular or combined inborn errors of immunity...
AMLMF - Overview: Acute Myeloid Leukemia (AML), Specified FISH, Varies
Detecting recurrent common chromosome abnormalities seen in patients with acute myeloid leukemia (AML) using a client-specified probe set An adjunct to chromosome studies in patients with AML Evaluating specimens in which chromosome...
LIPOG - Overview: Lipodystrophy Gene Panel, Varies
Providing a genetic evaluation for patients with a personal or family history suggestive of a hereditary lipodystrophy Establishing a diagnosis of a hereditary lipodystrophy
PEWE - Overview: Porphyrins Evaluation, Washed Erythrocytes
Preferred test for analysis of erythrocyte porphyrins Establishing a biochemical diagnosis of erythropoietic protoporphyria, and X-linked dominant protoporphyria
PBC2 - Overview: SP100 and GP210 Antibodies, IgG, Serum
Evaluating the risk of primary biliary cholangitis in anti-mitochondrial antibody (AMA)-negative patients by identification of Sp100 and gp210 antibodies Estimating risk in AMA-positive patients with incomplete feature of disease
DRVI2 - Overview: Dilute Russell's Viper Venom Time (DRVVT) Mix Ratio, Plasma
Detecting the presence or helping to exclude the presence of lupus anticoagulants (LA) Identifying LA that do not prolong the activated partial thromboplastin time (APTT) Evaluating unexplained prolongation of the APTT or prothrombin...
HSMBS - Overview: Hepatosplenomegaly Panel, Blood Spot
As a component of the initial evaluation of a patient presenting with hepatosplenomegaly, using dried blood spot specimens This test is not useful for the identification of carriers. This test should not be used as a monitoring tool for...
PFKC - Overview: Phosphofructokinase Enzyme Activity, Blood
Evaluation of individuals with Coombs-negative nonspherocytic hemolytic anemia Evaluation of individuals with exercise intolerance or myopathy Genetic studies in families with phosphofructokinase deficiency
PTU - Overview: Protein, Total, 24 Hour, Urine
Evaluation of kidney disease using a 24-hour urine collection Screening for monoclonal gammopathy
NITF - Overview: Nitrogen, Total, Feces
Determining nitrogen balance, when used in conjunction with 24-hour urine nitrogen measurement Assessing nutritional status (protein malnutrition) Evaluating protein catabolism
PTSC - Overview: Prothrombin Time (PT), Plasma
Screening to identify a deficiency of one or more of the clotting factors of the extrinsic coagulation system (I, II, V, VII, X) due to hereditary deficiency or acquired conditions such as liver disease, vitamin K deficiency, or a specific...
POU_F - Overview: Phosphorus, Feces
Workup of cases of chronic diarrhea Identifying the use of phosphate-containing laxatives contributing to osmotic diarrhea
TRYPA - Overview: Tryptase, Autopsy, Serum
Evaluation of autopsy cases in which anaphylaxis in the context of allergen exposure or mast cell activation is a suspected cause of death
HAEV0 - Overview: Hemolytic Anemia Summary Interpretation
Incorporating and summarizing subsequent results into an overall interpretation for the HAEV1 / Hemolytic Anemia Evaluation, Blood
GPI1 - Overview: Glucose Phosphate Isomerase Enzyme Activity, Blood
The evaluation of individuals with Coombs-negative chronic hemolysis
FDERM - Overview: Fungal Culture, Dermal
Recovery and identification of dermatophyte fungi from hair, skin, and nail infected specimens
IGGS4 - Overview: IgG4, Immunoglobulin Subclasses, Serum
Supporting the diagnosis of IgG4-related disease
AMLPC - Overview: Amylase, Pancreatic Cyst Fluid
Aiding in distinguishing between pseudocysts and other types of pancreatic cysts when used in conjunction with imaging studies, cytology, and other pancreatic cyst fluid tumor markers
AMIO - Overview: Amiodarone, Serum
Monitoring amiodarone therapy, especially when amiodarone is coadministered with other drugs that may interact Evaluating possible amiodarone toxicity Assessing patient compliance
ADLTX - Overview: Adulterants Survey, Chain of Custody, Random, Urine
Assess the possible adulteration of a urine specimen submitted for drug of abuse testing Providing the urine creatinine concentration for normalization purposes Chain of custody is required whenever the results of testing could be used...
CA19 - Overview: Carbohydrate Antigen 19-9 (CA 19-9), Serum
As a potential adjunct for diagnosis and monitoring of pancreatic cancer Potentially differentiating patients with cholangiocarcinoma and primary sclerosing cholangitis (PSC) from those with PSC alone
CARTA - Overview: Carbamazepine, Total, Serum
Monitoring therapy Determining compliance Assessing toxicity
SFINC - Overview: Cerebrospinal Fluid (CSF) IgG Index, Spinal Fluid
Aiding in the diagnosis of multiple sclerosis and other central nervous system inflammatory conditions using cerebrospinal fluid specimens
NITU - Overview: Nitrogen, Total, 24 Hour, Urine
Assessing nutritional status (protein malnutrition) Assessment of protein nutrition and nitrogen balance in hospitalized patients Evaluating protein catabolism Determining nitrogen balance, when used in conjunction with 24-hour fecal...
SIIRO - Overview: Sirolimus, Whole Blood
Monitoring whole blood sirolimus concentration during therapy, particularly in individuals coadministered cytochrome P450 (CYP) 3A4 substrates, inhibitors, or inducers Adjusting dose to optimize immunosuppression while minimizing...
TBGI - Overview: Thyroxine-Binding Globulin (TBG), Serum
Cases in which total thyroid hormone levels do not correlate with the thyrometabolic status, most commonly with pregnancy or the use of contraceptive steroids
T3FR - Overview: T3 (Triiodothyronine), Free, Serum
A second- or third-level test of thyroid function Confirmation of hyperthyroidism, supplementing the T4 (tetraiodothyronine), sensitive thyrotropin, and total T3 assays Evaluating clinically euthyroid patients who have an altered...
Interpretation for the evaluation of stiff-person spectrum disorders including the classical or focal forms, such as stiff-limb or stiff-trunk, and progressive encephalomyelitis with rigidity and myoclonus, using serum specimens
PLFAT - Overview: Cryptococcus Antigen Titer, Lateral Flow Assay, Pleural Fluid
Diagnosis of infection with Cryptococcus species
CALC5 - Overview: Calcium, Random, Urine
Measurement of calcium for the evaluation of calcium oxalate and calcium phosphate kidney stone risk, and calculation of urinary supersaturations Evaluation of bone diseases, including osteoporosis and osteomalacia
PRCON - Overview: Protein, Total, Random, Urine
Measurement of total protein for the assessment of orthostatic proteinuria
SDLDL - Overview: Small Dense Low Density Lipoprotein Cholesterol, Serum
Aiding in risk management of lipoprotein disorders associated with cardiovascular disease when used in conjunction with other lipid measurements and clinical evaluation
PSAFT - Overview: Prostate-Specific Antigen (PSA), Total and Free, Serum
As an aid in distinguishing prostate cancer from benign prostatic conditions in men aged 50 years and older with total PSA between 4.0 and 10.0 ng/mL with digital rectal examination findings that are not suspicious for cancer
HISGT - Overview: Histone Genes Mutation Analysis, Next-Generation Sequencing, Tumor
Identifying specific mutations within the H3-3A, H3-3B, H3C2, H3C3 and H3C14 genes that assist in tumor diagnosis/classification
EGFRW - Overview: EGFR Targeted Mutation Analysis with ALK Reflex, Tumor
Identifying non-small cell lung cancers that may benefit from treatment with epidermal growth factor receptor -targeted therapies or anaplastic lymphoma kinase inhibitors
RLTE4 - Overview: Leukotriene E4, Random, Urine
Aiding in the evaluation of patients at-risk for mast cell activation syndrome (eg, systemic mastocytosis, IgE-mediated allergies, or aspirin-exacerbated respiratory disease) using random urine collections
BHDZ - Overview: Birt-Hogg-Dube Syndrome, FLCN, Full Gene Analysis, Varies
Evaluating patients with a personal or family history suggestive of Birt-Hogg-Dube (BHD) syndrome Establishing a diagnosis of BHD syndrome allowing for targeted cancer surveillance based on associated risks Identifying variants within...
Information: Interpreting Laboratory Tests to Determine New vs. Residual Use of Marijuana - Insights
In this month's "Hot Topic," Paul Jannetto, Ph.D., identifies how to determine new vs. residual use of marijuana in a patient, and teaches how to calculate the carboxy-tetrahydrocannabinol (carboxy-THC)...
Laboratory and Pathology Research Roundup: March 12 - Insights
known. We performed laser microdissection (LCM) of glomeruli followed by mass spectrometry (MS) in 12 cases each of DDD, C3GN, and pretransplant kidney control biopsies....
COVID-19: At-home sample collection vs. at-home testing - Insights
The concept of at-home testing for COVID-19 sounds straightforward. But there's nuance to it that's important to understand. Right now, an at-home test for COVID-19 is not available, although there may be one coming soon. But in some areas,...
Clinic Laboratory and Pathology Research Roundup: Nov. 12 - Insights
This week’s Research Roundup highlights a mechanism for preventing asymmetric histone segregation onto replicating DNA strands.
Transfusion Toons: A1 vs. A2 - Insights
Justin Kreuter, M.D., Clinical Pathologist and Medical Director of the Mayo Clinic Blood Donor Center in Rochester, Minnesota, and Theresa Malin, an Education Specialist in Transfusion Medicine at Mayo Clinic, have launched “Transfusion...