TULAB - Overview: Francisella tularensis Antibody, IgM and IgG, ELISA, Serum
Aiding in the diagnosis of tularemia caused by Francisella tularensis This test should not be used as a test of cure as it is not quantitative. Patients may remain seropositive for months to years following resolution of disease.
TCL1A - Overview: T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) Immunostain, Technical Component Only
Identification of T-cell leukemia and lymphoma protein overexpression in neoplasms
TULI - Overview: Francisella tularensis Antibody, IgM and IgG, Technical Interpretation, Serum
Interpretation to aid in the diagnosis of tularemia caused by Francisella tularensis
LACO - Overview: Lacosamide, Serum
Monitoring serum concentrations of lacosamide to ensure compliance and appropriate dosing in specific clinical conditions (ie, severe kidney impairment, mild-to-moderate hepatic impairment, and kidney failure)
ITCON - Overview: Itraconazole, Serum
Verifying systemic absorption of orally administered itraconazole Patients with life-threatening fungal infections Patients considered at risk for poor absorption or rapid clearance of itraconazole
SIIRO - Overview: Sirolimus, Whole Blood
Monitoring whole blood sirolimus concentration during therapy, particularly in individuals coadministered cytochrome P450 (CYP) 3A4 substrates, inhibitors, or inducers Adjusting dose to optimize immunosuppression while minimizing...
MONOF - Overview: Monocyte Repartition by CD14/CD16, Blood
Aiding in the diagnosis and monitoring of chronic myelomonocytic leukemia
TAKRO - Overview: Tacrolimus, Blood
Monitoring whole blood tacrolimus concentration during therapy, particularly in individuals coadministered cytochrome P450 (CYP) 3A4 substrates, inhibitors, or inducers Adjusting dose to optimize immunosuppression while minimizing...
CITRA - Overview: Citrate Excretion, Random, Urine
Diagnosing risk factors for patients with calcium kidney stones using random urine specimens Monitoring results of therapy in patients with calcium stones or renal tubular acidosis
AMPHM - Overview: Amphetamine-Type Stimulants Confirmation, Meconium
Detecting in utero exposure to amphetamine-type stimulants up to 5 months before birth
HIPA - Overview: Hippuric Acid, Urine
Hippuric Acid, Urine
FCBDS - Overview: Cannabidiol, Serum
Cannabidiol, Serum
AMLAF - Overview: Acute Myeloid Leukemia (AML), FISH, Adult, Varies
This test should not be used to screen for residual acute myeloid leukemia (AML). Useful at diagnosis for detecting recurrent common chromosome abnormalities in adult patients with AML An adjunct to chromosome studies in patients with...
GNBLC - Overview: Bleeding Disorders, Comprehensive Gene Panel, Next-Generation Sequencing, Varies
Evaluating hereditary bleeding in patients with a personal or family history suggestive of a hereditary bleeding disorder Confirming a hereditary bleeding disorder diagnosis with the identification of a known or suspected disease-causing...
AHUSD - Overview: Atypical Hemolytic Uremic Syndrome Complement Panel, Serum and Plasma
Detecting deficiencies in the alternative pathway that can cause atypical-hemolytic uremic syndrome, dense deposit disease, and C3 glomerulonephritis A second-tier test that aids in the differential diagnosis of thrombotic...
ISNP - Overview: Inherited Sensory Neuropathy Gene Panel, Varies
Establishing a molecular diagnosis for patients with hereditary sensory (HSN) and autonomic neuropathy (HSAN) Identifying variants within genes known to be associated with HSN and HSAN, allowing for predictive testing of at-risk family...
Aiding in the diagnosis of neuroinvasive Lyme disease or neuroborreliosis due to Borrelia species associated with Lyme disease (eg, Borrelia burgdorferi, Borrelia garinii, Borrelia afzelli)
CHBVS - Overview: Chronic Hepatitis B Screen, Serum
Diagnosis and evaluation of patients at risk for or suspected of having chronic hepatitis B This test is not offered as a screening or confirmatory test for blood donor specimens. This test is not useful during the "window period" of...
CHSBP - Overview: Chronic Hepatitis B Monitoring Profile, Serum
Evaluating and monitoring individuals with known chronic hepatitis B Monitoring hepatitis B viral infectivity after resolution of acute hepatitis B
Diagnosing specific soft tissue and bone tumors (sarcoma) based on the observed gene fusions (eg, PAX3/FOXO1 gene fusion observed in alveolar rhabdomyosarcoma, EWSR1-FLI1 gene fusion for Ewing sarcoma, SS18-SSX1/2 gene fusion for synovial...
CMAMT - Overview: Chromosomal Microarray, Autopsy/Products of Conception/Stillbirth, Tissue
Diagnosis of congenital copy number changes in products of conception, including aneuploidy (ie, trisomy or monosomy) and structural abnormalities Diagnosing chromosomal causes for fetal death Determining recurrence risk of future...
CIB - Overview: Cutaneous Direct Immunofluorescence Assay, Varies
Confirming a diagnosis of bullous pemphigoid, cicatricial pemphigoid, pemphigoid gestationis and other variants of pemphigoid, all types of pemphigus, including paraneoplastic pemphigus (paraneoplastic multiorgan syndrome), dermatitis...
Detecting Chlamydia trachomatis and Neisseria gonorrhoeae in non-US Food and Drug Administration-approved specimen types This test is not intended for use in medico-legal applications. This test is not useful for the detection of...
DENGM - Overview: Dengue Virus Antibody, IgG and IgM, Serum
Aiding in the diagnosis of dengue virus infection
EHBAP - Overview: Ehrlichia/Babesia Antibody Panel, Immunofluorescence, Serum
As an adjunct in the diagnosis of infection with Anaplasma phagocytophilum, Ehrlichia chaffeensis, or Babesia microti Seroepidemiological surveys of the prevalence of the infection in certain populations
PKU - Overview: Phenylalanine and Tyrosine, Plasma
Monitoring effectiveness of dietary therapy in patients with hyperphenylalaninemia
HERGM - Overview: HER2, Gastric/Esophageal, Semi-Quantitative Immunohistochemistry, Manual
Determining overexpression of HER2 protein of gastric and esophageal adenocarcinoma in formalin-fixed, paraffin-embedded tissue sections (with reflex to FISH testing)
HIBAG - Overview: Histoplasma and Blastomyces Antigen, Enzyme Immunoassay, Serum
Diagnosing Histoplasma capsulatum or Blastomyces dermatitidis infection without differentiation between the organisms Monitor antigen levels following initiation of antifungal treatment
LGBBS - Overview: Globotriaosylsphingosine, Blood Spot
Screening of patients with Fabry disease using dried blood spots when a serum specimen is not available This test should not be used for newborn screening followup.
LGB3S - Overview: Globotriaosylsphingosine, Serum
Diagnosis and monitoring of Fabry disease
APOAB - Overview: Apolipoprotein A1 and B, Serum
Assessment of cardiovascular risk Follow-up studies in individuals with basic lipid measures inconsistent with risk factors or clinical presentation Definitive studies of cardiac risk factors in individuals with significant family...
AMISO - Overview: Amylase, Isoenzymes, Serum
Ruling out salivary amylase as the cause of elevated serum amylase
CD40 - Overview: B-Cell CD40 Expression by Flow Cytometry, Blood
Evaluating patients for hyper-IgM type 3 (HIGM3) syndrome due to defects in CD40, typically seen in patients less than 10 years Assessing B-cell immune competence in other clinical contexts, including autoimmunity, malignancy, and...
CCMVS - Overview: Congenital Cytomegalovirus (cCMV), Molecular Detection, PCR, Saliva
Aiding in the rapid diagnosis of cytomegalovirus (CMV) infections in neonates 21 days of age or younger using saliva specimens
SSA - Overview: SS-A/Ro Antibodies, IgG, Serum
Evaluating patients at-risk for connective tissue disease with or without interstitial lung disease Detection of both anti-SS-A 52 (Ro52) and SS-A 60 (Ro60) antibodies in serum
CRYPS - Overview: Cryptosporidium Antigen, Feces
Establishing the diagnosis of intestinal cryptosporidiosis
CEE52 - Overview: CD52 Cell Expression Evaluation, Varies
Detecting cell-surface antigens on malignant cells that are potential therapeutic antibody targets, specifically CD52 Determining the eligibility of patients for monoclonal antibody therapies Monitoring response to the therapeutic...
HCMM - Overview: Homocysteine (Total), Methylmalonic Acid, and Methylcitric Acid, Blood Spot
Second-tier assay of newborn screening specimens when abnormal propionyl carnitine or methionine concentrations are identified in a primary newborn screen
PCTTS - Overview: Purkinje Cell Cytoplasmic Antibody Type Tr (PCA-Tr) Titer, Serum
Serological testing for Purkinje cell cytoplasmic antibody-Tr for patients with acquired cerebellar ataxia of undetermined etiology, particularly if the patient has a history of Hodgkin lymphoma Reporting an end titer result from serum...
NTC3Z - Overview: NOTCH3 Gene, Full Gene Analysis, Varies
Establishing a molecular diagnosis in individuals with features of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and NOTCH3-related disorders Identifying disease-causing variants...
CYSGP - Overview: Cystinuria Gene Panel, Varies
Follow up for abnormal biochemical results suggestive of cystinuria Establishing a molecular diagnosis for patients with cystinuria Identifying variants within genes known to be associated with cystinuria, allowing for predictive testing...
TMP - Overview: Trimethoprim, Serum
Monitoring trimethoprim therapy to ensure drug absorption, clearance, or compliance
JCV - Overview: JC Virus Detection by In Situ Hybridization
Confirming a clinical and histopathologic diagnosis of progressive multifocal leukoencephalopathy
LITH - Overview: Lithium, Serum
Monitoring therapy of patients with bipolar disorders, including recurrent episodes of mania and depression Evaluating lithium toxicity
ASHA - Overview: Arsenic, Hair
Detection of nonacute arsenic exposure in hair specimens
ALS - Overview: Aldolase, Serum
Detection of muscle disease
CMACB - Overview: Chromosomal Microarray, Congenital, Blood
First-tier, postnatal testing for individuals with multiple anomalies that are not specific to well-delineated genetic syndromes, apparently nonsyndromic developmental delay or intellectual disability, or autism spectrum disorders as...
CHIMS - Overview: Chimerism Transplant Sorted Cells, Varies
Determining the relative amounts of donor and recipient cells in a specimen in sorted cell fractions An indicator of bone marrow transplant success
CFMP - Overview: Cystic Fibrosis, CFTR Gene, Variant Panel, Varies
Confirmation of a clinical diagnosis of cystic fibrosis Reproductive risk refinement via carrier screening for individuals in the general population Reproductive risk refinement via carrier screening for individuals with a family history...
F5M - Overview: 5-Methyltetrahydrofolate
5-Methyltetrahydrofolate
Mayo Clinic Ranked No. 1 Hospital Nationwide by U.S. News & World Report - Insights
Report’s 29th annual "Best Hospitals Honor Roll" published online on August 14. Mayo Clinic also ranked No. 1 in more specialties than any other hospital in the country....
NELL-1 [Test in Focus] - Insights
D., discusses how Mayo Clinic Laboratories’ new immunohistochemistry test for the detection of NELL-1 antigen, a biomarker for membranous nephropathy found in 10% to 15% of patients, provides diagnostic...
Looking Back on Clinical Chemistry 1 - Insights
in the Mayo Clinic Medical Laboratory Science program, takes a look back on her Clinical Chemistry 1 course....
Detection of (1→3)-𝝱-D-glucan as a Marker of Invasive Fungal Disease - Insights
In this month’s “Hot Topic,” Elitza Theel, Ph.D., will discuss the detection of (1→3)-β-D-glucan (BDG) in serum as a biomarker for the presence of invasive fungal infections....
Orexin-A/Hypocretin-1 for the Diagnosis of Type 1 Narcolepsy [Test in Focus] - Insights
test to perform as well as to interpret. The orexin-A/hypocretin-1 test is a sensitive and specific alternative to the MSLT to diagnose type 1 narcolepsy....