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GNANT - Overview: Antithrombin Deficiency, SERPINC1 Gene, Next-Generation Sequencing, Varies

Evaluating antithrombin AT deficiency in patients with a personal or family history suggestive of this hereditary thrombophilia Confirming an AT deficiency diagnosis with the identification of a known or suspected disease-causing...

PHEGP - Overview: Phenylalanine Disorders Gene Panel, Varies

Follow up for abnormal biochemical results suggestive of a phenylalanine disorder Establishing a molecular diagnosis for patients with phenylalanine disorders Identifying variants within genes known to be associated with phenylalanine...

2OHGP - Overview: 2-Hydroxyglutaric Aciduria Gene Panel, Varies

Follow up for abnormal biochemical results suggestive of 2-hydroxyglutaric aciduria Establishing a molecular diagnosis for patients with 2-hydroxyglutaric aciduria Identifying variants within genes known to be associated with...

AGDD - Overview: Alpha Globin Cluster Locus Deletion/Duplication, Varies

Diagnosis of alpha-thalassemia Carrier screening for individuals from high-risk populations for alpha-thalassemia This test is not useful for diagnosis or confirmation of beta-thalassemia or hemoglobinopathies.

WBGDD - Overview: Beta-Globin Gene Cluster, Deletion/Duplication, Varies

Determining the etiology of hereditary persistence of fetal hemoglobin (HPFH), delta-beta thalassemia, or other large deletions involving the beta-globin gene cluster Diagnosing less common causes of beta thalassemia; these large...

TFE3F - Overview: Alveolar Soft Part Sarcoma (ASPS)/Renal Cell Carcinoma (RCC), Xp11.23 (TFE3), FISH, Tissue

An aid in the diagnosis of alveolar soft-part sarcoma or renal cell carcinoma variant when used in conjunction with an anatomic pathology consultation

HIQNP - Overview: HIV-1 RNA Detection and Quantification, Prenatal, Plasma

Diagnosis of HIV-1 infection in pregnant individuals with acute or early HIV-1 infection Quantifying plasma HIV-1 RNA levels (viral load) in pregnant individuals living with HIV-1: -Before initiating anti-HIV-1 drug therapy (baseline viral...

HCCAD - Overview: Hepatitis C Virus Antibody Screen, Cadaveric or Hemolyzed Specimens, Asymptomatic, Serum

Screening cadaveric or hemolyzed serum specimens for hepatitis C virus (HCV) infection in asymptomatic individuals with or without risk factors for HCV infection Note: In accordance with National Coverage Determination guidance, this test...

APGAL - Overview: Galactose-Alpha-1,3-Galactose (Alpha-Gal) Mammalian Meat Allergy Profile, Serum

As an aid in diagnosis of an IgE mediated hypersensitivity allergy to non-primate mammalian red meat, such as beef, pork, venison, and meat-derived products, such as gelatin, via allergen profile testing This test is not useful in patients...

TLYME - Overview: Lyme IgM and IgG, Whole Cell Sonicate, ELISA, Serum

Supplemental testing for samples with positive or equivocal first-tier test results for antibodies to Lyme disease causing Borrelia species This test should not be used as a screening procedure for the general population.

NMOFS - Overview: Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay, Serum

Diagnosis of a neuromyelitis optica spectrum disorder (NMOSD) Diagnosis of autoimmune AQP4 channelopathy Diagnosis of neuromyelitis optica (NMO) Distinguishing NMOSD from multiple sclerosis early in the course of disease

SCAP - Overview: Spinocerebellar Ataxia Repeat Expansion Panel, Varies

Molecular confirmation of clinically suspected spinocerebellar ataxia when a specific subtype isn't suspected

SS18F - Overview: Synovial Sarcoma (SS), 18q11.2 (SS18 or SYT) Rearrangement, FISH, Tissue

Supporting the diagnosis of synovial sarcoma when used in conjunction with an anatomic pathology consultation

UBA1Q - Overview: UBA1 Mutation Quantitative Detection, VEXAS syndrome, Droplet Digital PCR, Varies

Identification of pathogenic variant(s) in the UBA1 gene in patients presenting with symptoms concerning for or consistent with VEXAS syndrome

LY27B - Overview: HLA-B27, Blood

Assisting in the diagnostic process of ankylosing spondylitis, juvenile rheumatoid arthritis, and reactive arthritis

APBCS - Overview: Adaptor Protein 3 Beta2 (AP3B2) Antibody, Cell-Binding Assay, Serum

The differential diagnosis of patients presenting with mixed cerebellar and sensory ataxia and myeloneuropathy Evaluating AP3B2 (adaptor protein 3 beta2)-IgG by cell-binding assay using serum specimens

CRTFR - Overview: Creatinine, Random, Urine

Normalizing urinary analytes to account for the variation in urinary concentrations between individuals when using random urine collections

10_IS - Overview: Factor X Inhibitor Screen, Plasma

Detecting the presence of a specific factor inhibitor directed against coagulation factor X

DLAC - Overview: D-Lactate, Plasma

As an adjunct to urine D-lactate (preferred) for the diagnosis of D-lactate acidosis

CRETR - Overview: Creatinine, Random, Urine

Normalization of urinary analytes to account for the variation in urinary concentrations between individuals when using random urine collections

CITR2 - Overview: Citrate Concentration, Random, Urine

Diagnosing risk factors for patients with calcium kidney stones Monitoring results of therapy in patients with calcium stones or renal tubular acidosis

RCTUR - Overview: Creatinine, Random, Urine

Calculation of creatinine clearance, a measure of renal function, when used in conjunction with serum creatinine Normalization of urinary analytes by creatinine concentration to account for the variation in urinary concentrations between...

CRE2 - Overview: Creatinine, Urine

Normalization of urinary analytes to account for the variation in urinary concentrations between individuals when using random urine collections

ALBLI - Overview: Limited Bleeding Diathesis Profile Interpretation

Interpretation of testing performed as part of a profile to detect of the more common potential causes of abnormal bleeding (eg, factor deficiencies/hemophilia, von Willebrand disease, factor-specific inhibitors) and a simple screen to...

ITCON - Overview: Itraconazole, Serum

Verifying systemic absorption of orally administered itraconazole Patients with life-threatening fungal infections Patients considered at risk for poor absorption or rapid clearance of itraconazole

KIBM - Overview: Ki-67(MIB-1), Breast, Semi-Quantitative Immunohistochemistry, Manual

Determining proliferation of tumor cells in paraffin-embedded tissue blocks from patients diagnosed with breast carcinoma

LACO - Overview: Lacosamide, Serum

Monitoring serum concentrations of lacosamide to ensure compliance and appropriate dosing in specific clinical conditions (ie, severe kidney impairment, mild-to-moderate hepatic impairment, and kidney failure)

GLURA - Overview: Glucose, Random, Serum

Diagnosing and managing diabetes mellitus and other carbohydrate metabolism disorders including gestational diabetes, neonatal hypoglycemia, idiopathic hypoglycemia, and pancreatic islet cell carcinoma

NCDTS - Overview: Neurochondrin Antibody, Tissue Immunofluorescence Titer, Serum

Detecting neurochondrin-IgG in serum from patients presenting with cerebellar and brainstem syndrome Reporting an end titer result from serum specimens

NCDCS - Overview: Neurochondrin Antibody, Cell-Binding Assay, Serum

Evaluating neurochondrin-IgG by cell-binding assay using serum from patients presenting with cerebellar and brainstem syndrome

NF4FS - Overview: Neurofascin-155 IgG4, Flow Cytometry, Serum

Evaluating patients with an underlying demyelinating neuropathy Diagnosis of a neurofascin-155 IgG4 mediated neuropathy

PGKC - Overview: Phosphoglycerate Kinase Enzyme Activity, Blood

Evaluation of individuals with Coombs-negative nonspherocytic hemolytic anemia, especially if X-linked inheritance pattern. Evaluation of individuals with myopathic or neurologic symptoms

PA - Overview: Procainamide and N-Acetylprocainamide, Serum

Monitoring therapy with procainamide Assessing compliance Evaluating procainamide toxicity

PEAR - Overview: Pear, IgE, Serum

Establishing a diagnosis of an allergy to pear Defining the allergen responsible for eliciting signs and symptoms Identifying allergens: -Responsible for allergic response and/or anaphylactic episode -To confirm sensitization prior to...

SP7TC - Overview: Septin-7 Antibody, Tissue Immunofluorescence Titer, Spinal Fluid

Detecting septin-7 IgG in cerebrospinal fluid (CSF) specimens Reporting an end titer result from CSF specimens

TPIC - Overview: Triosephosphate Isomerase Enzyme Activity, Blood

Evaluating individuals with chronic nonspherocytic hemolytic anemia Evaluating individuals with early onset neurologic impairment Genetic counseling for families with triosephosphate isomerase deficiency

SP5TC - Overview: Septin-5 Antibody, Tissue Immunofluorescence, Spinal Fluid

Detecting septin-5 IgG in spinal fluid (CSF) specimens Reporting an end titer result from CSF specimens

ROC - Overview: Rubeola (Measles) Antibodies, IgG and IgM, Spinal Fluid

Diagnosing central nervous system rubeola (measles) virus infection and/or subacute sclerosing panencephalitis

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Learn more about Mayo Clinic Laboratories’ robust approach to testing for primary ciliary dyskinesia, a rare genetic condition that can lead to chronic otosinopulmonary disease and infertility in men....

CPT Codes and LOINC Update: September 2019 - Insights

View a full list of new CPT codes, Test Classification Updates, LOINC Codes, and Z-Codes posted to mayocliniclabs.com during the month of September 2019....

https://www.mayocliniclabs.com/it-mmfiles/cpt-code-changes.xlsx

note, CPT Code changes listed on this document are effective January 1st, 2025.*** ***Updates and other changes may occur, and be reflected on this document, leading up to 2025*** ***CPT Code Updates...

MCL Primary Ciliary Dyskinesia Genetic Testing Patient Information MC1235297

MCL Primary Ciliary Dyskinesia Genetic Testing Patient Information Complete print Reset Form Primary Ciliary Dyskinesia Genetic Testing Patient Information Instructions Accurate interpretation reporting...

New communication process for CPT Code changes - Insights

Mayo Clinic Laboratories (MCL) is pleased to announce an essential update to our CPT code communication process and website layout. This change is designed to bring timely notifications for accurate billing...