MSDW - Overview: Multiple Sulfatase Deficiency, Leukocytes
Supporting the biochemical diagnosis of multiple sulfatase deficiency in whole blood specimens This test is not useful for carrier detection.
PARVP - Overview: Parvovirus B19, Molecular Detection, PCR, Plasma
Diagnosing parvovirus B19 infection in plasma specimens
CARNS - Overview: Carnitine, Serum
Evaluation of patients with a clinical suspicion of a wide range of conditions including organic acidemias, fatty acid oxidation disorders, and primary carnitine deficiency using serum specimens
CARN - Overview: Carnitine, Plasma
Evaluation of patients with a clinical suspicion of a wide range of conditions including organic acidemias, fatty acid oxidation disorders, and primary carnitine deficiency using plasma specimens
COKMX - Overview: Cocaine and Metabolite Confirmation, Chain of Custody, Meconium
Detecting in utero drug exposure up to 5 months before birth Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen by...
HGHAR - Overview: Mercury, Hair
Detecting mercury exposure in hair specimens
Only indicated for formalin-fixed paraffin-embedded specimens from patients diagnosed with large B-cell lymphoma
DPYDQ - Overview: Dihydropyrimidine Dehydrogenase Genotype, Varies
Identifying individuals with genetic variants in DPYD who are at increased risk of toxicity when prescribed 5-fluorouracil (5-FU) or capecitabine chemotherapy treatment
Aiding in the diagnosis of multiple sclerosis and other central nervous system inflammatory conditions as a part of a profile
COKEM - Overview: Cocaine and Metabolites Confirmation, Meconium
Detecting in utero drug exposure up to 5 months before birth
PSY - Overview: Psychosine, Blood Spot
Aids in the biochemical detection of Krabbe disease and saposin A cofactor deficiency Second-tier testing or follow up testing after an abnormal newborn screening result in an infant for Krabbe disease This test is not capable of...
F822B - Overview: Hemophilia A F8 Gene, Intron 22 Inversion Known Mutation, Whole Blood
First-tier molecular testing for male patients affected with severe hemophilia A, when a familial intron 22 inversion has been previously identified Determining hemophilia A carrier status for at-risk female patients, ie, individuals with...
QHV6C - Overview: Human Herpesvirus-6 A and B DNA Detection and Quantification, PCR, Spinal Fluid
As an adjunct in the rapid diagnosis of human herpesvirus-6 infection using cerebrospinal fluid specimens This test should not be used to screen asymptomatic patients.
FBART - Overview: Bartonella Antibody Panel, IFA CSF
Bartonella Antibody Panel, IFA CSF
FPD5C - Overview: Pyridoxal 5-phosphate (CSF)
Pyridoxal 5-phosphate (CSF)
ALBLD - Overview: Bleeding Diathesis Profile, Limited, Plasma
Detection of the more common potential causes of abnormal bleeding (eg, factor deficiencies/hemophilia, von Willebrand disease, factor-specific inhibitors) and a simple screen to evaluate for an inhibitor or severe deficiency of factor XIII...
DTPCO - Overview: ThinPrep with Human Papillomavirus (HPV) Co-Test-Diagnostic, Varies
Detection and diagnosis of cervical carcinoma or intraepithelial lesions and the presence or absence of high-risk human papillomavirus (HR-HPV) in women over age 30 at risk for cervical neoplasia Detecting high-risk HPV genotypes...
XALDZ - Overview: X-Linked Adrenoleukodystrophy, Full Gene Analysis, Varies
Confirming a diagnosis of X-linked adrenoleukodystrophy Identifying a variant in the ABCD1 gene
MPS2Z - Overview: Hunter Syndrome, Full Gene Analysis, Varies
Confirmation of a diagnosis of mucopolysaccharidosis type II (Hunter syndrome) Carrier testing when there is a family history of mucopolysaccharidosis type II (Hunter syndrome), but disease-causing variants have not been previously...
QHV6P - Overview: Human Herpesvirus-6 A and B DNA Detection and Quantification, PCR, Plasma
As an adjunct in the rapid diagnosis of human herpesvirus-6 infection using plasma specimens This test should not be used to screen asymptomatic patients
LNBAI - Overview: Lyme Central Nervous System Infection IgG, Antibody Index, Spinal Fluid
Providing antibody index information to aid in the diagnosis of neuroinvasive Lyme disease or neuroborreliosis due to Borrelia species associated with Lyme disease (eg, Borrelia burgdorferi, Borrelia garinii, Borrelia afzelli)
PNRP - Overview: Pneumocystis jiroveci, Molecular Detection, PCR, Varies
Preferred test for detection of Pneumocystis
PLAIF - Overview: Phospholipase A2 Receptor (PLA2R), Renal Biopsy
Distinguishing primary membranous nephropathy from secondary membranous nephropathy
LPSBF - Overview: Lipase, Body Fluid
Determining whether pancreatic inflammation or pancreatic fistula may be contributing to a pathological accumulation of fluid
BUPS - Overview: Buprenorphine Screen, Random, Urine
Screening for drug abuse or use of buprenorphine
PLINK - Overview: Paroxysmal Nocturnal Hemoglobinuria, PI-Linked Antigen, Blood
Screening for and confirming the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) Monitoring patients with PNH
MMLSG - Overview: Antimicrobial Susceptibility, Acid-Fast Bacilli, Slowly Growing, Varies
Determination of resistance of slowly growing mycobacteria to antimicrobial agents
17OHP - Overview: 17-Hydroxypregnenolone, Serum
As an ancillary test for congenital adrenal hyperplasia (CAH), particularly in situations in which a diagnosis of both 21- and 11-hydroxylase deficiency have been ruled out Confirming a diagnosis of 3-beta-hydroxysteroid dehydrogenase...
FROPI - Overview: Ropivacaine, Serum/Plasma
Ropivacaine, Serum/Plasma
HEXBZ - Overview: Sandhoff Disease, HEXB Gene, Full Gene Analysis, Varies
Follow up for abnormal biochemical results suggestive of Sandhoff disease Establishing a molecular diagnosis for patients with Sandhoff disease Identifying variants within genes known to be associated with Sandhoff disease, allowing for...
AFXN - Overview: Friedreich Ataxia, Repeat Expansion Analysis, Varies
Molecular confirmation of clinically suspected Friedreich ataxia
APOL1 - Overview: APOL1 Genotype, Varies
Determining an individual's APOL1 genotype This test is not useful for clinical management of individuals with APOL1 risk genotypes. This test alone is not useful for determining eligibility for donation or receipt of kidney...
AMLPF - Overview: Acute Myeloid Leukemia (AML), FISH, Pediatric, Varies
This test should not be used to screen for residual acute myeloid leukemia (AML). Useful at diagnosis for detecting recurrent common chromosome abnormalities in pediatric patients with AML An adjunct to chromosome studies in patients with...
EBVQN - Overview: Epstein-Barr Virus DNA Detection and Quantification, Plasma
Diagnosis of Epstein-Barr virus (EBV)-associated infectious mononucleosis in individuals with equivocal or discordant EBV serologic marker test results Diagnosis of post-transplant lymphoproliferative disorders (PTLD), especially in...
SCN5A - Overview: Brugada Syndrome, SCN5A Full Gene Analysis, Varies
Providing a genetic evaluation for patients with a personal or family history suggestive of Brugada syndrome Establishing a diagnosis of Brugada syndrome
PNEFS - Overview: Neuroimmunology Antibody Follow-up, Serum
Monitoring patients who have previously tested positive for one or more antibodies within the past 5 years in a Mayo Neuroimmunology Laboratory serum evaluation
PTNZ - Overview: PTEN Hamartoma Tumor Syndrome, PTEN Full Gene Analysis, Varies
Evaluating patients with a personal or family history suggestive of PTEN hamartoma tumor syndrome (PHTS) Establishing a diagnosis of PHTS allowing for targeted cancer surveillance based on associated risks Identifying variants within...
KRABZ - Overview: Krabbe Disease, Full Gene Analysis and Large (30 kb) Deletion, Varies
Second-tier test for confirming a diagnosis of Krabbe disease Carrier testing for individuals with a family history of Krabbe disease in the absence of known sequence variants in the family
MPSWB - Overview: Mucopolysaccharidosis, Blood
Supporting the biochemical diagnosis of mucopolysaccharidoses type I, II, III, IV, or VI Quantification of heparan sulfate, dermatan sulfate, and keratan sulfate in whole blood specimens
VLCZ - Overview: Very Long Chain Acyl-CoA Dehydrogenase Deficiency, Full Gene Analysis, Varies
Confirmation of a diagnosis of very long chain acyl-CoA dehydrogenase (VLCAD) deficiency Carrier screening in cases where there is a family history of VLCAD deficiency, but an affected individual is not available for testing or...
WEEP - Overview: Western Equine Encephalitis Antibody, IgG and IgM, Serum
Aiding the diagnosis of Western equine encephalitis using serum specimens
USTEK - Overview: Ustekinumab Quantitation with Antibodies, Serum
Evaluation of loss of response to therapy Quantification of ustekinumab in human serum Trough level quantitation for evaluation of patients treated with ustekinumab Detection of antibodies to ustekinumab in human serum
RISAP - Overview: Risankizumab Quantitation with Antibodies, Serum
Evaluation of patients with limited primary (initial) response to or secondary loss of response to risankizumab
FXS - Overview: Fragile X Syndrome, Molecular Analysis, Varies
Confirming a diagnosis of fragile X syndrome, fragile X tremor/ataxia syndrome, or premature ovarian insufficiency caused by expansions in the FMR1 gene Determining carrier status for individuals with a family history of fragile X...
F822P - Overview: Hemophilia A F8 Gene, Intron 22 Inversion Mutation Analysis, Prenatal
Prenatal testing for hemophilia A when a F8 intron 22 inversion has been identified in a family member
HBAG - Overview: Hepatitis B Virus Surface Antigen, Serum
Diagnosis of acute, recent, or chronic hepatitis B Determination of chronic hepatitis B status This test should not be used as a screening or confirmatory test for blood donor specimens.
ESR1T - Overview: ESR1 Mutation Analysis, Next-Generation Sequencing, Tumor
Assisting in the clinical management of patients with metastatic breast cancer by identifying tumors with evolving resistance to endocrine therapy Stratifying prognosis of metastatic breast cancer
DMITO - Overview: Mitochondrial DNA Deletion Heteroplasmy, ddPCR, Varies
Assessing the heteroplasmy level of previously detected large mitochondrial DNA (mtDNA) deletions. Screening family members for previously detected large mtDNA deletions. This test is not recommended for first tier diagnostic testing...
MULT - Overview: Zygosity Testing (Multiple Births), Varies
Determining genetic risk for an individual whose twin or triplet is affected with a genetic disorder for which a specific genetic test is not available (or such testing is uninformative) Assessment of risks prenatally when one fetus of...
HBAGP - Overview: Hepatitis B Virus Surface Antigen Prenatal, Serum
Diagnosis of acute, recent, or chronic hepatitis B Determination of chronic hepatitis B status Screening pregnant women for evidence of chronic hepatitis B (or hepatitis B carrier state) to identify neonates who are at high risk of...
Mayo Clinic Ranked No. 1 Hospital Nationwide by U.S. News & World Report - Insights
Report’s 29th annual "Best Hospitals Honor Roll" published online on August 14. Mayo Clinic also ranked No. 1 in more specialties than any other hospital in the country....
NELL-1 [Test in Focus] - Insights
D., discusses how Mayo Clinic Laboratories’ new immunohistochemistry test for the detection of NELL-1 antigen, a biomarker for membranous nephropathy found in 10% to 15% of patients, provides diagnostic...
Looking Back on Clinical Chemistry 1 - Insights
in the Mayo Clinic Medical Laboratory Science program, takes a look back on her Clinical Chemistry 1 course....
Detection of (1→3)-𝝱-D-glucan as a Marker of Invasive Fungal Disease - Insights
In this month’s “Hot Topic,” Elitza Theel, Ph.D., will discuss the detection of (1→3)-β-D-glucan (BDG) in serum as a biomarker for the presence of invasive fungal infections....
Orexin-A/Hypocretin-1 for the Diagnosis of Type 1 Narcolepsy [Test in Focus] - Insights
test to perform as well as to interpret. The orexin-A/hypocretin-1 test is a sensitive and specific alternative to the MSLT to diagnose type 1 narcolepsy....