TLCU - Overview: Immunoglobulin Total Light Chains, Urine
Monitoring patients whose urine demonstrates large M-spikes Confirming the quantitation of specimens that show M-spikes by electrophoresis Detecting urine monoclonal proteins and identification of specimens that need urine protein...
Supporting the diagnosis of low-grade fibromyxoid sarcoma when used in conjunction with an anatomic pathology consultation
TALDO - Overview: Polyols, Quantitative, Urine
Diagnosing deficiencies of transaldolase, transketolase, sedoheptulose, or ribose-5-phosphate isomerase
IMTF - Overview: Inflammatory Myofibroblastic Tumors (IMT), 2p23 (ALK) Rearrangement, FISH, Tissue
Supporting the diagnosis of inflammatory myofibroblastic tumors when used conjunction with an anatomic pathology consultation
STRNG - Overview: Strongyloides Antibody, IgG, Serum
Screening for the presence of IgG-class antibodies to Strongyloides This test is not useful for monitoring patient response to therapy as IgG-class antibodies to Strongyloides may remain detectable following resolution of infection.
GPSYP - Overview: Glucopsychosine, Plasma
Second-tier test when newborn screening results with reduced beta-glucosidase (GBA) activity are identified Diagnosis and monitoring of patients with Gaucher disease using plasma specimens Supporting a biochemical diagnosis of Gaucher...
BAIPD - Overview: Bile Acids for Peroxisomal Disorders, Serum
Biomarker for peroxisomal biogenesis disorders, such as Zellweger spectrum disorder and single enzyme defects of bile acid synthesis, including D-bifunctional protein deficiency and alpha methyl CoA racemases Monitoring patients receiving...
Aiding in the identification of individuals with an adaptive immune response to SARS-CoV-2, indicating prior infection or vaccination
OPATX - Overview: Opiates Confirmation, Chain of Custody, Random, Urine
Detection and quantification of codeine, hydrocodone, oxycodone, morphine, hydromorphone, oxymorphone, noroxycodone, noroxymorphone, norhydrocodone, dihydrocodeine, and naloxone in urine Chain of custody is required whenever the results of...
Assessing cytomegalovirus (CMV)-specific immune competence in allo-hematopoietic stem cell transplantation patients who are at risk for developing late CMV disease (beyond day 100 after transplant) Assessing CMV-specific immune competence...
Aiding in risk assessment of patients with clinical signs and symptoms consistent with development of preeclampsia with severe features This test is not intended for making a diagnosis of preeclampsia or preeclampsia with severe...
PLAFL - Overview: Platelet Surface Glycoprotein by Flow Cytometry, Blood
Identification of markedly decreased CD41 (GPIIb) and CD61 (GPIIIa) expression levels, which are diagnostic for Glanzmann thrombasthenia Identification of markedly decreased CD42a (GPIX) and CD42b (GPIb-alpha) expression levels, which are...
PSPTG - Overview: Phosphatidylserine/Prothrombin Antibody, IgG, Serum
Detecting IgG antibodies against phosphatidylserine/prothrombin complex in patients with strong suspicion of antiphospholipid syndrome (APS) who are negative for the APS criteria laboratory tests (lupus anticoagulant, IgG and IgM...
VZVPV - Overview: Varicella-Zoster Virus, Molecular Detection, PCR, Varies
Rapid (qualitative) detection of varicella-zoster virus DNA in clinical specimens for laboratory diagnosis of disease due to this virus This test should not be used to screen asymptomatic patients.
TVRNA - Overview: Trichomonas vaginalis, Nucleic Acid Amplification, Varies
Detecting Trichomonas vaginalis in urine, cervical/endocervical or vaginal specimen types
1A2Q - Overview: Cytochrome P450 1A2 Genotype, Varies
Identifying individuals who are poor, intermediate, normal (extensive) or rapid metabolizers of drugs metabolized by cytochrome P450 1A2 to assist drug therapy decision making
PMMIL - Overview: Phosphomannomutase and Phosphomannose Isomerase, Leukocytes
Diagnosing congenital disorders of glycosylation Ia (phosphomannomutase-2 deficiency: PMM2-CDG) and Ib (phosphomannose isomerase deficiency: MPI-CDG) as measured in leukocytes Follow-up testing for patients with an abnormal type I CDG...
RPR14 - Overview: Respiratory Profile, Region 14, Central California, Serum
Assessing sensitization to various inhalant allergens commonly found in Central California Defining the allergen responsible for eliciting signs and symptoms Identifying allergens: -Responsible for allergic response and/or anaphylactic...
RPR3 - Overview: Respiratory Profile, Region 3, South Atlantic (GA, N.FA, SC), Serum
Assessing sensitization to various inhalant allergens commonly found in the South Atlantic region, including Georgia, Northern Florida, and South Carolina Defining the allergen responsible for eliciting signs and symptoms Identifying...
RPR2 - Overview: Respiratory Profile, Region 2, Mid-Atlantic (DC, DE, MD, NC, VA), Serum
Assessing sensitization to various inhalant allergens commonly found in the Mid-Atlantic region including the District of Columbia, Delaware, Maryland, North Carolina, and Virginia Defining the allergen responsible for eliciting signs and...
RPR13 - Overview: Respiratory Profile, Region 13, Southern Coastal California, Serum
Assessing sensitization to various inhalant allergens commonly found in the Southern Coastal California region Defining the allergen responsible for eliciting signs and symptoms Identifying allergens: -Responsible for allergic response...
RPR4 - Overview: Respiratory Profile, Region 4, Sub-tropic Florida (Florida S. of Orlando), Serum
Assessing sensitization to various inhalant allergens commonly found in sub-tropic Florida, which is south of Orlando Defining the allergen responsible for eliciting signs and symptoms Identifying allergens: -Responsible for allergic...
RPR15 - Overview: Respiratory Profile, Region 15, Intermountain West (Southern ID, NV), Serum
Assessing sensitization to various inhalant allergens commonly found in the Intermountain West region including southern Idaho and Nevada Defining the allergen responsible for eliciting signs and symptoms Identifying...
RPR19 - Overview: Respiratory Profile, Region 19, Puerto Rico, Serum
Assessing sensitization to various inhalant allergens commonly found in Puerto Rico Defining the allergen responsible for eliciting signs and symptoms Identifying allergens: -Responsible for allergic response and/or anaphylactic...
RPR10 - Overview: Respiratory Profile, Region 10, Southwestern Grasslands (OK, TX), Serum
Assessing sensitization to various inhalant allergens commonly found in the Southwestern Grasslands region, including Oklahoma and Texas Defining the allergen responsible for eliciting signs and symptoms Identifying...
Assessing sensitization to various inhalant allergens commonly found in the Rocky Mountain region including Arizona, Colorado, Idaho, New Mexico, Utah, and Wyoming Defining the allergen responsible for eliciting signs and symptoms...
RPR9 - Overview: Respiratory Profile, Region 9, Great Plains (KS, ND, NE, SD), Serum
Assessing sensitization to various inhalant allergens commonly found in the Great Plains region including Kansas, North Dakota, Nebraska, and South Dakota Defining the allergen responsible for eliciting signs and symptoms Identifying...
RPR8 - Overview: Respiratory Profile, Region 8, Central Midwest (IA, IL, MO), Serum
Assessing sensitization to various inhalant allergens commonly found in the Central Midwest region including Iowa, Illinois, and Missouri Defining the allergen responsible for eliciting signs and symptoms Identifying...
RPR7 - Overview: Respiratory Profile, Region 7, Northern Midwest (MI, MN, WI), Serum
Assessing sensitization to various inhalant allergens commonly found in the Northern Midwest region including Michigan, Minnesota, and Wisconsin Defining the allergen responsible for eliciting signs and symptoms Identifying...
RPR6 - Overview: Respiratory Profile, Region 6, South Central (AL, AR, LA, MS), Serum
Assessing sensitization to various inhalant allergens commonly found in the South Central region including Alabama, Arkansas, Louisiana and Mississippi Defining the allergen responsible for eliciting signs and symptoms Identifying...
Assessing sensitization to various inhalant allergens commonly found in the inland Northwest region, including Oregon and central and east Washington Defining the allergen responsible for eliciting signs and symptoms Identifying...
Assessing sensitization to various inhalant allergens commonly found in the Pacific Northwest including the region of Northwestern California, Western Oregon and Washington Defining the allergen responsible for eliciting signs and...
TERTD - Overview: TERT Promoter Mutation Analysis, Droplet Digital PCR, Tumor
Identifying specific mutations within the TERT promoter that assist in tumor diagnosis/classification
TP53 - Overview: TP53 Mutation Analysis, Next-Generation Sequencing, Tumor
Assisting in the clinical management of patients with cancer This test is not intended for the evaluation of patients suspected of having an inherited or germline TP53 cancer syndrome (eg, Li Fraumeni syndrome).
THSCM - Overview: Thyroid Function Cascade, Serum
Screening for a diagnosis of thyroid disease
Confirmatory detection of human T-cell lymphotropic virus types I and II (HTLV-I and HTLV-II)-specific IgG antibodies in human serum specimens that are consistently reactive by initial screening tests Differentiating between HTLV-I- and...
Assessing pure isolates of Helicobacter pylori to predict clarithromycin resistance or susceptibility
HSVG - Overview: Herpes Simplex Virus (HSV) Type 1- and Type 2-Specific Antibodies, IgG, Serum
Determining whether a patient has been previously exposed to herpes simplex virus (HSV) types 1 and 2 Distinguishing between infection caused by HSV types 1 and 2, especially in patients with subclinical or unrecognized HSV infection...
GPSY - Overview: Glucopsychosine, Blood Spot
Second-tier test when newborn screening results with reduced beta-glucosidase (GBA) activity are identified Diagnosis and monitoring of patients with Gaucher disease using dried blood spot specimens Monitoring a patient's response to...
FGF1F - Overview: FGFR1 (8p11.2) Amplification, FISH, Tissue
Providing prognostic information and guiding treatment primarily for patients with squamous cell carcinoma of the lung, breast, esophagus, thymus, and other locations
MRSAP - Overview: Methicillin Resistant Staphylococcus aureus, PCR, Nasal
Rapid screening test for Staphylococcus aureus nasal carriage that, if positive, indicates whether the S aureus is methicillin susceptible or resistant This test should not be used to guide or monitor treatment for methicillin-resistant S...
AGAW - Overview: Alpha-Galactosidase, Leukocytes
Diagnosis of Fabry disease in male patients Verifying abnormal serum alpha-galactosidase results in male patients with a clinical presentation suggestive of Fabry disease This test is not useful for patients undergoing a work-up for a...
VASC - Overview: Antineutrophil Cytoplasmic Antibodies Vasculitis Panel, Serum
Evaluating patients with clinical features of anti-neutrophil cytoplasmic antibody-associated vasculitis, specifically granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis
APGH - Overview: Alpha-Subunit Pituitary Tumor Marker, Serum
Adjunct in the diagnosis of pituitary tumors As part of the follow-up of treated pituitary tumor patients Differential diagnosis of thyrotropin-secreting pituitary tumor versus thyroid hormone resistance Differential diagnosis of...
CTNBT - Overview: B-Catenin Mutation Analysis, Next-Generation Sequencing, Tumor
Distinguishing desmoid-type fibromatosis from other soft tissue tumors by assessing gene targets within the beta-catenin (CTNNB1) gene
ABOPC - Overview: Arbovirus Antibody Panel, IgG and IgM, Spinal Fluid
Aiding in the diagnosis of arboviral encephalitis (California [LaCrosse], St Louis, Eastern equine, and Western equine encephalitis)
SGTF - Overview: MYB (6q23) Rearrangement FISH, Tissue
Assessing for MYB gene rearrangements in patients with primary salivary gland carcinoma to aid in confirming or excluding the diagnosis of primary salivary gland adenoid cystic carcinomas
MSH6 - Overview: MSH6 Immunostain, Technical Component Only
Identifying patients at high risk for having hereditary nonpolyposis colorectal cancer, also known as Lynch syndrome, in an immunopanel including MSH6 and other mismatch repair markers Evaluation of tumor tissue to identify patients at...
MCADZ - Overview: Medium-Chain Acyl-CoA Dehydrogenase (MCAD) Deficiency Full Gene Analysis, Varies
Confirmation of diagnosis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency (as a follow-up to biochemical analyses) Screening of at-risk carriers of MCAD deficiency when an affected relative has not had molecular testing Diagnosis...
Diagnosis of a neuromyelitis optica spectrum disorder (NMOSD) Diagnosis of autoimmune AQP4 channelopathy Distinguishing NMOSD from multiple sclerosis early in the course of disease
Information: Interpreting Laboratory Tests to Determine New vs. Residual Use of Marijuana - Insights
In this month's "Hot Topic," Paul Jannetto, Ph.D., identifies how to determine new vs. residual use of marijuana in a patient, and teaches how to calculate the carboxy-tetrahydrocannabinol (carboxy-THC)...
Laboratory and Pathology Research Roundup: March 12 - Insights
known. We performed laser microdissection (LCM) of glomeruli followed by mass spectrometry (MS) in 12 cases each of DDD, C3GN, and pretransplant kidney control biopsies....
COVID-19: At-home sample collection vs. at-home testing - Insights
The concept of at-home testing for COVID-19 sounds straightforward. But there's nuance to it that's important to understand. Right now, an at-home test for COVID-19 is not available, although there may be one coming soon. But in some areas,...
Clinic Laboratory and Pathology Research Roundup: Nov. 12 - Insights
This week’s Research Roundup highlights a mechanism for preventing asymmetric histone segregation onto replicating DNA strands.
Transfusion Toons: A1 vs. A2 - Insights
Justin Kreuter, M.D., Clinical Pathologist and Medical Director of the Mayo Clinic Blood Donor Center in Rochester, Minnesota, and Theresa Malin, an Education Specialist in Transfusion Medicine at Mayo Clinic, have launched “Transfusion...