24th International Surgical Pathology Symposium - Insights
The 24th International Surgical Pathology Symposium addresses common and uncommon diagnostic dilemmas encountered within surgical pathology practice. Prior to the symposium, participants will have the opportunity to review clinical...
24th International Surgical Pathology Symposium - Insights
The 24th International Surgical Pathology Symposium addresses common and uncommon diagnostic dilemmas encountered within surgical pathology practice. Prior to the symposium, participants will have the opportunity to review clinical...
Applying the Staffing-to-Workload Methodology: Same-Day Testing Staffing Model - Insights
Mike Baisch, Principal Systems Engineer at Mayo Clinic, discusses how to apply the staffing-to-workload methodology to accommodate same-day testing requirements.
March 2023 - Clinical Biochemistry - Insights
This "Pathways" program provides a Clinical Pathology case that includes a history, potential answers, rationale, and relevant references. This case sub-specialty is Clinical Biochemistry.
Oncology Testing - Mayo Clinic Laboratories
Our comprehensive test menu includes testing to aid in providing both diagnostic and prognostic information and aid in the treatment selection across the full spectrum of malignancies.
Cytogenetic Testing for Pediatric Patients With Hematologic Malignancies - Insights
In this month's "Hot Topic," Patricia Greipp, D.O., discusses fluorescence in situ hybridization, or FISH testing, particularly related to pediatric patients with hematologic malignancies.
Diagnostic Testing Algorithms for Celiac Disease - Insights
In this month's "Hot Topic," Melissa Snyder, Ph.D., co-director of the antibody immunology laboratory at Mayo Clinic, discusses celiac disease and the role of diagnostic testing algorithms.
IMPACTS Team Continues to Combat Life-Threatening Arthropod-Borne Infections in Belize - Insights
Now in its second year of a five-year initiative to better understand and detect arboviruses in Belize, the IMPACTS (Integrated Mayo Clinic Program for Arbovirus Community health education Training and Surveillance) project has expanded its...
Raising the Bar on Newborn Screening Test Performance - Insights
Newborn screening panels that test for a variety of conditions are available in every state; however, test performance and response rate by each state are very different. Mayo Clinic's Biochemical Genetics Laboratory created the...
Gadolinium-based contrast agents (GBCAs) have revolutionized MRIs by increasing the clinical utility and detection sensitivity of these exams. GBCAs also contain gadolinium, a rare earth metal with unique chemical properties. This article...
In the fall of 2017, Shayla Polanchek, a recent recipient of a heart transplant at Mayo Clinic in Rochester, Minnesota, returned to campus to review the specimen of her old heart, the one that had been removed from her chest. She had asked...
High-resolution targeted stimulant and phencyclidine (PCP) screen - Insights
In this month’s “Hot Topic,” Paul Jannetto, Ph.D., discusses the high-resolution targeted stimulant and PCP screening test from Mayo Clinic Laboratories, which offers sensitivity and specificity for use in the monitoring and management of...
NGS for Myeloid Neoplasm Evaluation - Insights
In this month's "Hot Topic," David Viswanatha, M.D., discusses updates to Mayo Clinic's next-generation sequencing (NGS) for myeloid neoplasm evaluation, involving new test targets, the rationale for new genetic regions, alignments with the...
In this month's "Hot Topic," Brad Karon, M.D., Ph.D., reviews pediatric venipuncture volumes in this year’s Phlebotomy Top Gun case-based presentation as requested by previous Phlebotomy conference attendees.
Lyme Disease, Part 2: Borrelia mayonii-A New Cause of Lyme Disease in Upper Midwest - Insights
In this “Hot Topic,” Bobbi Pritt, M.D., discusses how Lyme disease is the most common vector-borne illness in the United States and Europe and caused primarily by Borrelia burgdorferi in the United States, while B burgdorferi, B afzelii,...
MGMR - Overview: Myasthenia Gravis Evaluation with Muscle-Specific Kinase (MuSK) Reflex, Serum
Diagnosing autoimmune myasthenia gravis (MG) in adults and children Distinguishing autoimmune from congenital MG in adults and children or other acquired forms of neuromuscular junction transmission disorders Establishing a quantitative...
New tests launched in November - Insights
In November 2021, Mayo Clinic Laboratories announced thirty four new tests along with numerous reference value changes, obsolete tests, and algorithm changes.
AHUSD - Overview: Atypical Hemolytic Uremic Syndrome Complement Panel, Serum and Plasma
Detecting deficiencies in the alternative pathway that can cause atypical-hemolytic uremic syndrome, dense deposit disease, and C3 glomerulonephritis A second-tier test that aids in the differential diagnosis of thrombotic...
Top Gun Phlebotomy - Butterfly Use: The Good, the Bad, and the Ugly - Insights
In this month’s “Hot Topic,” Brad Karon, M.D., Ph.D., will discuss recent information on the advantages and disadvantages of using butterfly needles for blood collection.
Congenital disorders of glycosylation - Insights
In this month’s “Hot Topic,” Gessi Pino, a genetic counselor in the Biochemical Genetics Lab at Mayo Clinic, and Kimiyo Raymond, M.D., a clinical consultant in the laboratory and an expert in Congenital Disorders of Glycosylation (CDG),...
Optic Neuritis in the Era of Biomarkers - Insights
Antibodies to aquaporin-4 and myelin oligodendrocyte glycoprotein (MOG) are recently described biomarkers seen in a subset of atypical optic neuritis which have revolutionized our understanding of the condition. In this “Hot Topic,” my...
Autoimmune Encephalitis Misdiagnosis - Insights
In this month's "Hot Topic," Eoin Flanagan, M.B., B. Ch., discusses the important issue of autoimmune encephalitis misdiagnosis and identifies red flags that be useful in clinical practice to suggest alternative diagnoses and highlight...
Neuroimmunology: Updates and antibody test utilization - Insights
In this month’s “Hot Topic,” Andrew McKeon, M.B., B.Ch., M.D., reviews the use of neurological phenotype-based evaluations, the move away from the paraneoplastic evaluation, and upcoming changes to test profiles.
In this month's "Hot Topic," Paul Jannetto, Ph.D., identifies how to determine new vs. residual use of marijuana in a patient, and teaches how to calculate the carboxy-tetrahydrocannabinol (carboxy-THC) to creatinine ratio along with a...
Our Mayo Clinic colleagues are in San Diego for the 60th American Society of Hematology Annual Meeting and Exhibition. Follow this blog for live updates from #ASH18 as we attend the conference, mingle with colleagues at booth #2927, and...
Behind the scenes in neural antibody testing - Insights
In this month’s “Hot Topic,” John Mills, Ph.D., explains the central role of tissue immunofluorescence in the identification of neural antibodies and discusses the benefits of an integrated laboratory approach to the development and...
In this month's "Hot Topic," Bobbi Pritt, M.D., describes the challenges to traditional microscopy for the detection of protozoa in stool specimens, lists potential uses of artificial intelligence in parasite detection, and discusses...
Applying MASS-FIX to Urine Samples - Insights
In this month's "Hot Topic," David Murray, M.D., Ph.D., reviews the role of urine testing for monoclonal gammopathies and discusses Mayo Clinic’s use of MASS-FIX to replace traditional immunofixation testing.
Diagnostic Testing Algorithms for Celiac Disease - Insights
In this month’s “Hot Topic,” Melissa Snyder, Ph.D., will review the diagnostic testing algorithms for celiac disease and highlight the advantages and limitations of certain tests, including serology and genetic assays.
The diagnosis of Myeloproliferative Neoplasm (MPN) must include an integrated approach and combine the clinical findings with laboratory results. In our latest “Hot Topic,” Rong He, M.D., discusses the subclassification of MPNs and the use...
Infective Endocarditis - Insights
In this month’s “Hot Topic,” Robin Patel, M.D., will review the laboratory methods used to diagnose infectious endocarditis. Specifically, she’ll discuss the role of blood cultures, nucleic acid amplification tests, histopathology, and...
Updated Test Promises Fewer False Positives in Newborn Screening for Krabbe Disease - Insights
Mayo Clinic’s Biochemical Genetics Laboratory has announced an updated second-tier test to detect Krabbe disease (KD) that uses psychosine (PSY) as a disease marker. The new test method has significantly higher sensitivity to detect this...
New tests launched in December - Insights
In December 2022, Mayo Clinic Laboratories announced seventy-eight new tests along with numerous reference value changes, obsolete tests, and algorithm changes.
Justin Fugelsang and Zach Pedowitz have never met. Yet both young men were diagnosed with a rare form of Charcot-Marie-Tooth disease, called sorbitol dehydrogenase (SORD) deficiency, and both found clarity through Mayo Clinic Laboratories'...
In this month’s “Hot Topic,” Paul Jannetto, Ph.D., discusses the high-resolution targeted opioid screening test from Mayo Clinic Laboratories, which offers sensitivity and specificity for use in the monitoring and management of patients who...
Pathways Case Studies: September 2023 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for September include the following sub-specialties: Cardiovascular Pathology,...
Helicobacter pylori Infection: Serologic Testing Not Recommended [Communiqué] - Insights
Helicobacter pylori (H pylori) infection is among the most common bacterial infections worldwide with approximately one-half of the world’s population infected. Several invasive and noninvasive testing methods are available to detect H...
Pathways Case Studies: February 2023 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for February include the following sub-specialties: Clinical Informatics,...
Alzheimer's Disease Testing - Mayo Clinic Laboratories
We have developed an innovative evaluation for Alzheimer's disease, which uses CSF biomarkers to achieve a high concordance with amyloid PET scan.
Testing for Antibodies to SS-A/Ro in Autoimmune Diseases - Insights
In this month’s “Hot Topic,” Anne Tebo, Ph.D., discusses recent updates in the testing for anti-SS-A/Ro antibodies in systemic autoimmune rheumatic diseases.
Diagnostic Exploratory Testing - Insights
In this month's "Hot Topic," Nicole Boczek, Ph.D., assistant professor and laboratory director in the Department of Laboratory Medicine and Pathology, and Sarah Barnett, M.S., CGC, discuss diagnostic exploratory testing, explain why it’s...
In this “Hot Topic,” Elitza Theel, Ph.D., discusses how common cases of presumed Lyme disease go unreported each year and discusses scenarios in which testing for Lyme disease is indicated and reviews both recommended and inappropriate...
Pathways Case Studies: April 2021 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for April include the following sub-specialties: Genitourinary Pathology,...
Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury. Based on the etiology of MPGN, Drs. Sethi and Fervenza proposed a new histologic classification of MPGN into Ig/IC-mediated MPGN and complement-mediated...
Osmotic fragility testing - Insights
In this month’s “Hot Topic,” James Hoyer, M.D., discusses the importance of using a control tube during osmotic fragility testing.
The Secrets of Cryoprecipitate: A Blood Banking Process - Insights
In this month’s “Hot Topic,” Jessie Swanson and Michelle Soland from the Component Laboratory will discuss the process improvement that helped decrease the standard cryoprecipitate dosage and the positive impact it has on patients.
Pathways Case Studies: March 2023 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for March include the following sub-specialties: Breast Pathology, Cytopathology,...
Pathways Case Studies: February 2021 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for February include the following sub-specialties: Neuropathology,...
ACHE 2017 Congress on Healthcare Leadership Live Blog - Insights
Andy Cousin, FACHE, Director of Product Management and Marketing for Mayo Medical Laboratories, is attending this year's ACHE Congress on Health Care Leadership conference in Chicago. He will be sharing his thoughts and photos from the...
Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury. Based on the etiology of MPGN, Drs. Sethi and Fervenza proposed a new histologic classification of MPGN into Ig/IC-mediated MPGN and complement-mediated...