Evaluating patients with signs and symptoms of a connective tissue disease in whom the test for antinuclear antibodies is positive
Testing is not useful in patients without demonstrable antinuclear antibodies.
Test Id | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
SSA | SS-A/Ro Ab, IgG, S | Yes | Yes |
SSB | SS-B/La Ab, IgG, S | Yes | Yes |
SM | Sm Ab, IgG, S | Yes | Yes |
RNP | RNP Ab, IgG, S | Yes | Yes |
SCL70 | Scl 70 Ab, IgG, S | Yes | Yes |
JO1 | Jo 1 Ab, IgG, S | Yes | Yes |
For more information see Connective Tissue Disease Cascade.
Multiplex Flow Immunoassay
Anti-ENA (Antibodies to Extractable Nuclear Antigens)
Anti-La
Anti-Ribonuclear Protein
Anti-RNP (Anti-Ribonucleoprotein)
Anti-Ro
Anti-Sjogren's Syndrome
Anti-Sm (Smith)
Anti-Smith (SM) Antigen
Anti-SSA (Anti-Sjogren's Syndrome A)
Anti-SSB (Anti-Sjogren's Syndrome B)
Anti-U(1)RNP (Anti-Ribonucleoprotein)
Antibodies to Extractable Nuclear Antigens
Autoantibodies to Jo 1 Antigen
Autoantibodies to Sm (Smith)
Autoantibodies to SSA (Ro)
Autoantibodies to SSB (La)
Autoantibodies to U(1)RNP
Connective Tissue Disease Autoantibody Panel (2 tests)
DNA Topoisomerase 1 Antibodies
ENA (Extractable Nuclear Antigens), Anti
ENA/ADNA
Extractable Nuclear Antigens, Anti
Histidyl-tRNA Synthetase Antibodies
Immunology Profile (ENA)
Jo 1 Antibodies
LA (Anti-La)
La (Anti-SSB)
Polymyositis Antibodies
Ribonucleoprotein (RNP) Autoantibodies
RNP (Anti-RNP)
Ro (Anti-SSA)
Scl 70 Antibodies
Scleroderma Antibodies (? FOR SPECIFIC TEST)
Sjogren's Syndrome
Sm (Anti-Sm) (Smith)
Sm (Smith) Autoantibodies
Smith Antigen, Anti
SmRNP Autoantibodies
SSA (Anti-SSA)
SSB (Anti-SSB)
Topoisomerase 1 Antibodies
U(1)RNP (Ribonucleoprotein) Autoantibodies
Autoantibodies to Scl 70 Antigen
For more information see Connective Tissue Disease Cascade.
Serum
Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Specimen Volume: 0.5 mL
If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.
0.35 mL
Gross hemolysis | Reject |
Gross lipemia | Reject |
Gross icterus | OK |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Serum | Refrigerated (preferred) | 21 days | |
Frozen | 21 days |
Evaluating patients with signs and symptoms of a connective tissue disease in whom the test for antinuclear antibodies is positive
Testing is not useful in patients without demonstrable antinuclear antibodies.
For more information see Connective Tissue Disease Cascade.
SSA, SSB, SM, and RNP are extractable nuclear antigens (ENA) that occur in patients with several different connective tissue diseases. Scl 70 (topoisomerase 1) is a 100-kD nuclear and nucleolar enzyme. Scl 70 antibodies are considered to be specific for scleroderma (systemic sclerosis) and are found in up to 60% of patients with this connective tissue disease. Scl 70 antibodies are more common in patients with extensive cutaneous involvement and interstitial pulmonary fibrosis, and are considered a poor prognostic sign.(1) JO1 is a member of the amino acyl-tRNA synthetase family of enzymes found in all nucleated cells and a marker for the disease polymyositis.
For more information, see individual unit codes.
SS-A/Ro ANTIBODIES, IgG
<1.0 U (negative)
> or =1.0 U (positive)
Reference values apply to all ages.
SS-B/La ANTIBODIES, IgG
<1.0 U (negative)
> or =1.0 U (positive)
Reference values apply to all ages.
Sm ANTIBODIES, IgG
<1.0 U (negative)
> or =1.0 U (positive)
Reference values apply to all ages.
RNP ANTIBODIES, IgG
<1.0 U (negative)
> or =1.0 U (positive)
Reference values apply to all ages.
Scl 70 ANTIBODIES, IgG
<1.0 U (negative)
> or =1.0 U (positive)
Reference values apply to all ages.
Jo 1 ANTIBODIES, IgG
<1.0 U (negative)
> or =1.0 U (positive)
Reference values apply to all ages.
A positive result is consistent with a connective tissue disease.
For more information, see individual unit codes.
1. Homburger H, Larsen S: Detection of specific antibodies. In Clinical Immunology: Principles and Practice. First edition. Edited by R Rich, T Fleisher, B Schwartz, et al. St. Louis, Mosby-Year Book, Inc, 1996, pp 2096-2109
2. Targoff I: Autoantibodies in polymyositis. Rheum Dis Clin North Am 1992;18:455
See individual unit codes.
Monday through Saturday
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.
86235 x 6
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
ENAE | Ab to Extractable Nuclear Ag Eval,S | 90228-8 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
JO1 | Jo 1 Ab, IgG, S | 33571-1 |
RNP | RNP Ab, IgG, S | 29958-6 |
SCL70 | Scl 70 Ab, IgG, S | 47322-3 |
SM | Sm Ab, IgG, S | 18323-6 |
SSA | SS-A/Ro Ab, IgG, S | 33610-7 |
SSB | SS-B/La Ab, IgG, S | 33613-1 |