Aiding in the diagnosis of central nervous system infection by mumps
Immunofluorescence
Mumps Ab, IgG and IgM, CSF
Mumps IgG and IgM, Spinal Fluid
CSF
Container/Tube: Sterile vial
Specimen Volume: 0.5 mL
If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.
0.1 mL
Gross hemolysis | OK |
Gross lipemia | OK |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
CSF | Refrigerated (preferred) | 14 days | |
Frozen | 14 days |
Aiding in the diagnosis of central nervous system infection by mumps
There is only one serotype of mumps virus that infects humans. Mumps has been recognized since antiquity by virtue of the parotitis, which is often a striking clinical feature of the disease. Generally, a trivial childhood illness, the varied presentation of mumps reflects the widespread invasion of visceral organs and central nervous system that commonly follows infection with mumps virus.
IgG: <1:5
IgM: <1:10
Reference values apply to all ages.
Detection of organism-specific antibodies in the cerebrospinal fluid (CSF) may suggest central nervous system infection. However, these results are unable to distinguish between intrathecal antibodies and serum antibodies introduced into the CSF at the time of lumbar puncture or from a breakdown in the blood-brain barrier. The results should be interpreted with other laboratory and clinical data prior to a diagnosis of central nervous system infection
No significant cautionary statements
1. Wolinsky J, Waxham MN: Mumps virus. In: Fields BN, Knipe DM eds. Fields Virology. Vol 1. 2nd ed. Raven Press; 1990:989-1011
2. Litman N, Baum SG: Mumps virus. In Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:2087-2092
Mumps virus antibodies are detected by the indirect immunofluorescence procedure. Cerebrospinal fluid from the patient is diluted and placed in wells of substrate slides containing mumps virus-infected cells. A fluorescent antibody conjugate is then allowed to react with the virus-infected cells.(Brown GC, Baublis JV, O'Leary TP: Development and duration of mumps fluorescent antibodies in various immunoglobulin fractions of human serum. J Immunol. 1970;104:86-94; Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020)
Monday through Friday
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.
86735 x 2
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
CMUMP | Mumps Virus Ab, IgG and IgM, CSF | 88458-5 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
1414 | Mumps Virus Ab, IgG | 21401-5 |
1415 | Mumps Virus Ab, IgM | 21402-3 |