Test Catalog

Test Id : FMNPP

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Motor Neuropathy Panel

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Overview

Test Catalog

Method Name
A short description of the method used to perform the test

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Quantitative Immunoturbidimetry

Quantitative Capillary Electrophoresis

Qualitative Immunofixation Electrophoresis

Quantitative Spectrophotometry

Colorimetric Assay

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

Motor Neuropathy Panel

Aliases
Lists additional common names for a test, as an aid in searching

Alpha, Beta, and Gamma globulins

Ganglioside Ab

MAG Ab

Protein Electrophoresis

SGPG Ab

Specimen Type
Describes the specimen type validated for testing

Serum SST

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Specimen Type: Serum

Container/Tube: Serum Separator Tube (SST)

Specimen Volume: 4 mL

Collection Instructions: Draw blood in a serum gel tube(s). Spin down and send 4 mL serum refrigerated in plastic vial.

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory

2 mL

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

Hemolysis Mild reject; Gross reject
Lipemia Mild OK; Gross reject
Icterus Mild OK; Gross reject
Other Plasma, CSF, or other body fluids. Heat-inactivated, contaminated specimens

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Serum SST Refrigerated (preferred) 7 days
Frozen 30 days

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Asialo-GM1 Antibodies, IgG/IgM:

29 IV or less: Negative

30-50 IV: Equivocal

51-100 IV: Positive

101 IV or greater: Strong Positive

 

GM1 Antibodies, IgG/IgM:

29 IV or less: Negative

30-50 IV: Equivocal

51-100 IV: Positive

101 IV or greater: Strong Positive

 

GD1a Antibodies, IgG/IgM:

29 IV or less: Negative

30-50 IV: Equivocal

51-100 IV: Positive

101 IV or greater: Strong Positive

 

GD1b Antibodies, IgG/IgM:

29 IV or less: Negative

30-50 IV: Equivocal

51-100 IV: Positive

101 IV or greater: Strong Positive

 

GQ1b Antibodies, IgG/IgM:

29 IV or less: Negative

30-50 IV: Equivocal

51-100 IV: Positive

101 IV or greater: Strong Positive

 

Ganglioside (Asialo-GM1, GM1, GM2, GD1a, GD1b, and GQ1b) Antibodies, IgG/IgM:

Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1), and the neutral glycolipid, asialo GM1 are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. GD1a antibodies are associated with different variants of Guillain-Barre syndrome (GBS) particularly acute motor axonal neuropathy while GD1b antibodies are predominantly found in sensory ataxic neuropathy syndrome. Anti-GQ1b antibodies are seen in more than 80 percent of patients with Miller-Fisher syndrome and may be elevated in GBS patients with ophthalmoplegia. The role of isolated anti-GM2 antibodies is unknown. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease. 

 

Total Protein, Serum:

6.3-8.2 g/dL

 

Albumin:

3.75-5.01 g/dL

 

Alpha 1 Globulin:

0.19-0.46 g/dL

 

Alpha 2 Globulin:

0.48-1.05 g/dL

 

Beta Globulin:

0.48-1.10 g/dL

 

Gamma:

0.62-1.51 g/dL

 

Immunoglobulin A:

0 - 2 years: 2 - 126 mg/dL

3 - 4 years: 14 - 212 mg/dL

5 - 9 years: 52 - 226 mg/dL

10 - 14 years: 42 - 345 mg/dL

15 - 18 years: 60 - 349 mg/dL

19 years and older: 68 - 408 mg/dL

 

Immunoglobulin G:

0 - 2 years: 242 - 1108 mg/dL

3 - 4 years: 485 - 1160 mg/dL

5 - 9 years: 514 - 1672 mg/dL

10 - 14 years: 581 - 1652 mg/dL

15 - 18 years: 479 - 1433 mg/dL

19 years and older: 768 - 1632 mg/dL

 

Immunoglobulin M:

0 - 2 years: 21 - 215 mg/dL

3 - 4 years: 26 - 155 mg/dL

5 - 9 years: 26 - 188 mg/dL

10 - 14 years: 47 - 252 mg/dL

15 - 18 years: 26 - 232 mg/dL

19 years and older: 35-263 mg/dL

 

Monoclonal Protein:

Units: g/dL

 

Myelin Associated Glycoprotein (MAG) Antibody, IgM:

Less than 1000 TU

An elevated IgM antibody concentration greater than 999 TU against myelin-associated glycoprotein (MAG) suggests active demyelination in peripheral neuropathy. A normal concentration (less than 999 TU) generally rules out an anti-MAG antibody-associated peripheral neuropathy.

TU= Titer Units

 

Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibody, IgM:       

Less than 1.00 IV

The majority of sulfate-3-glucuronyl paragloboside (SGPG) IgM-positive sera will show reactivity against MAG. Patients who are SGPG IgM positive and MAG IgM negative may have multi-focal motor neuropathy with conduction block.

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Sunday through Saturday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

3 to 12 days

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

ARUP Laboratories

Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their account representative. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

This test was developed and its perfomance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

82784 x 3

83516 x 7

84155

84165

86334

LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
FMNPP Motor Neuropathy Panel Not Provided
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
Z4539 MAG Antibody, IgM 17314-6
Z4540 SGPG Antibody, IgM 31666-1
Z4541 Asialo-GM1 Antibodies, IgG-IgM 44737-5
Z4542 GM1 Antibodies, IgG-IgM 63244-8
Z4543 GD1a Antibodies, IgG-IgM 48656-3
Z4544 GD1b Antibodies, IgG-IgM 26870-6
Z4545 GQ1b Antibodies, IgG-IgM 31674-5
Z4546 Immunoglobulin G 2465-3
Z4547 Immunoglobulin A 2458-8
Z4548 Immunoglobulin M 2472-9
Z4549 Total Protein, Serum 2885-2
Z4550 Albumin 1751-7
Z4551 Alpha 1 Globulin 2865-4
Z4552 Alpha 2 Globulin 2868-8
Z4553 Beta Globulin 2871-2
Z4554 Gamma 2874-6
Z4555 Immunofixation 25700-6
Z4556 SPEP-IFE Interpretation 49275-1
Z4557 EER Motor Neuropathy Panel 11526-1
Z6250 Monoclonal Protein Not Provided

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports

Test Update Resources

Change Type Effective Date
Test Changes - Referral Fee 2023-02-02
New Test 2022-08-15