Test Id : FFMSS
Maternal Serum Screening, Integrated, Specimen #1, PAPP-A, NT
Useful For
Suggests clinical disorders or settings where the test may be helpful
First-trimester screening test for trisomy 21 (Down syndrome), trisomy 18, and open neural tube defects
Profile Information
A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test Id | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| FPAIN | Patient Information | No | Yes |
| FMAS1 | Maternal Screen INT-1 | No | Yes |
Method Name
A short description of the method used to perform the test
Quantitative Chemiluminescent Immunoassay
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Aliases
Lists additional common names for a test, as an aid in searching
MS INT-1
Specimen Type
Describes the specimen type validated for testing
Serum
ORDER QUESTIONS AND ANSWERS
| Question ID | Description | Answers |
|---|---|---|
| Z5934 | Maternal Date of Birth | |
| Z5935 | Maternal Weight | |
| Z5936 | Patient Weight Units | |
| Z5937 | Due Date | |
| Z5938 | Dating Method | |
| Z5939 | Last Menstrual Period | |
| Z5940 | Number of Fetuses | |
| Z5942 | Race of Mother | |
| Z5943 | Diabetic Status | |
| Z5944 | Current Smoking | |
| Z5945 | Valproic-Carbamazepine | |
| Z5946 | Previous Trisomy Preg | |
| Z5947 | Family History of NTD | |
| Z5948 | In Vitro Fertilization | |
| Z5949 | Donor Egg Age at Harvest | |
| Z5950 | Repeat Specimen | |
| Z5951 | Date of Ultrasound | |
| Z5952 | Crown Rump Length | |
| Z5953 | Nuchal Translucency | |
| Z5954 | Sonographer Name | |
| Z5955 | Sonographer Cert Number | |
| Z5956 | Reading MD Name | |
| Z5957 | Reading MD Cert Number |
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Specimen # 1 collection must occur between 10 weeks, 0 days and 13 weeks, 6 days gestation. If gestational age is based on Crown-Rump length (CRL), the specimen must be collected when the CRL is between 32.4 - 83.9 mm.
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable.
2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
3. Ship refrigerate.
Note:
Submit with order: Patient's date of birth, current weight, number of fetuses present, patient's race, if the patient was diabetic at the time of conception, if there is a known family history of neural tube defects, if the patient has had a previous pregnancy with a trisomy, if the patient is currently smoking, if the patient is taking valproic acid or carbamazepine (Tegretol), if this is a repeat sample, and the age of the egg donor if in vitro fertilization.
In addition to the above:
If an NT measurement is performed: the date of ultrasound, the CRL measurement, the nuchal translucency (NT) measurement and the name and certification number of the sonographer are required. NT must be measured when the CRL is between 38-83.9mm. The NT measurement must be performed by an ultrasonographer that is certified by the Fetal Medicine Foundation (FMF).
OR
If no NT measurement is performed: a due date or CRL measurement with the date of ultrasound is required.
See the PATIENT HISTORY FOR MATERNAL SERUM TESTING form.
Special Instructions
Library of PDFs including pertinent information and forms related to the test
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.
0.3 mL
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
| Gross Hemolysis | Reject |
| Plasma | Reject |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Ambient | 72 hours | ||
| Frozen | 365 days |
Useful For
Suggests clinical disorders or settings where the test may be helpful
First-trimester screening test for trisomy 21 (Down syndrome), trisomy 18, and open neural tube defects
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
An interpretive report will be provided.
Part 2 must be completed in order to receive an interpretable result.
If the second specimen is not received for sequential screening, the results are uninterpretable and no maternal risk will be provided.
Interpretation
Provides information to assist in interpretation of the test results
The first specimen of an integrated Maternal Serum Screening is used to measure PAPP-A. A second sample must be submitted for a final interpretive report. Acceptable date ranges to draw the second samples will be provided in the Integrated-1 report. Final interpretive report will be available when the second specimen test results are complete.
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Sunday through Saturday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees :
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their account representative. For assistance, contact Customer Service.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
CPT codes are provided by the performing laboratory.
84163
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| FFMSS | Maternal Serum Screen INT, Sp-1 | Not Provided |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| Z5959 | Nuchal Translucency (NT) | 12146-7 |
| Z5960 | Nuchal Translucency (NT), Twin B | 12146-7 |
| Z5961 | Maternal Screen Interpretation | 49586-1 |
| Z5962 | Maternal Age At Delivery | 21612-7 |
| Z5963 | Maternal Weight | 29463-7 |
| Z5964 | Estimated Due Date | 11778-8 |
| Z5965 | Gestational Age Calculated at Coll. | 18185-9 |
| Z5966 | Dating | 21299-3 |
| Z5967 | Number of Fetuses | 11878-6 |
| Z5968 | Maternal Race | 21484-1 |
| Z5969 | Smoking | 64234-8 |
| Z5970 | Family History of Aneuploidy | 32435-0 |
| Z5971 | Specimen | 19151-0 |
| Z5972 | Crown Rump Length | 11957-8 |
| Z5973 | Crown Rump Length, Twin B | 11957-8 |
| Z5974 | Sonographer Certification Number | 49089-6 |
| Z5975 | Sonographer Name | 49088-8 |
| Z5976 | Ultrasound Date | 34970-4 |
| Z5977 | Best date to draw sample nmb 2 by | 33882-2 |
| Z5978 | EER Maternal Serum, Integrated, Sp1 | 11526-1 |
| Z5958 | PAPP-A Maternal | 48407-1 |