| Web: | mayocliniclabs.com |
|---|---|
| Email: | mcl@mayo.edu |
| Telephone: | 800-533-1710 |
| International: | +1 855-379-3115 |
| Values are valid only on day of printing | |
Test Id : MBX
Muscle Pathology Consultation
Useful For
Suggests clinical disorders or settings where the test may be helpful
Suggests clinical disorders or settings where the test may be helpful
Obtaining a rapid, expert opinion on muscle biopsy specimens for neuromuscular disease
Reflex Tests
Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.
Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.
| Test Id | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IHPCI | IHC Initial | No, (Bill Only) | No |
| IHPCA | IHC Additional | No, (Bill Only) | No |
| IFPCI | IF Initial | No, (Bill Only) | No |
| IFPCA | IF Additional | No, (Bill Only) | No |
| SS2PC | SpecStain, Grp II, other | No, (Bill Only) | No |
| SS3PC | SpecStain, Grp III, enzyme | No, (Bill Only) | No |
| HCFPC | SpecStain, frozen | No, (Bill Only) | No |
| COSPC | Consult, Outside Slide | No, (Bill Only) | No |
| CSPPC | Consult, w/Slide Prep | No, (Bill Only) | No |
| CUPPC | Consult, w/USS Prof | No, (Bill Only) | No |
| CRHPC | Consult, w/Comp Rvw of His | No, (Bill Only) | No |
| LV4RP | Level 4 Gross and Microscopic, RB | No, (Bill Only) | No |
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
A battery of enzyme histochemical stains will be performed on frozen tissue; additional histochemical stains or immunostains may be performed on frozen tissue; other tests can be performed as indicated and will be charged separately. The reviewing neuromuscular pathologist will determine the need for additional testing.
For all consultations, ancillary testing necessary to determine a diagnosis is ordered at the discretion of the Mayo Clinic neuromuscular pathologist. An interpretation, which includes an evaluation of the specimen and determination of a diagnosis, will be provided within a formal pathology report.
Frozen tissue sent for consultation: Appropriate additional stains may be performed at an additional charge.
Slides sent for consultation: Special stains and studies performed on the case should be sent with the case for review. In order to determine an accurate diagnosis, some of these stains or studies may be deemed to warrant repeat testing at an additional charge at the discretion of the reviewing Mayo Clinic neuromuscular pathologist. The interpreting neuromuscular pathologist may also request frozen tissue to perform additional studies that may be considered necessary for diagnosis.
Note: Testing requested by the referring physician (immunostains, etc) may not be performed if deemed unnecessary by the reviewing Mayo neuromuscular pathologist. Electron microscopic studies are not performed on muscle biopsy specimens. For more information see Why Electron Microscopy is Not Performed on Muscle Biopsy Specimens in Special Instructions.
See Pathology Consultation Ordering Algorithm in Special Instructions.
Special Instructions
Library of PDFs including pertinent information and forms related to the test
Library of PDFs including pertinent information and forms related to the test
Method Name
A short description of the method used to perform the test
A short description of the method used to perform the test
Muscle Biopsy Surgical Pathology Consultation and/or Review of Outside Material
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Yes
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Lists a shorter or abbreviated version of the Published Name for a test
Muscle Path Consult
Aliases
Lists additional common names for a test, as an aid in searching
Lists additional common names for a test, as an aid in searching
Muscle Biopsy, Enzyme Histochemistry
Muscle Tissue
Skeletal Muscle Tissue
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
A battery of enzyme histochemical stains will be performed on frozen tissue; additional histochemical stains or immunostains may be performed on frozen tissue; other tests can be performed as indicated and will be charged separately. The reviewing neuromuscular pathologist will determine the need for additional testing.
For all consultations, ancillary testing necessary to determine a diagnosis is ordered at the discretion of the Mayo Clinic neuromuscular pathologist. An interpretation, which includes an evaluation of the specimen and determination of a diagnosis, will be provided within a formal pathology report.
Frozen tissue sent for consultation: Appropriate additional stains may be performed at an additional charge.
Slides sent for consultation: Special stains and studies performed on the case should be sent with the case for review. In order to determine an accurate diagnosis, some of these stains or studies may be deemed to warrant repeat testing at an additional charge at the discretion of the reviewing Mayo Clinic neuromuscular pathologist. The interpreting neuromuscular pathologist may also request frozen tissue to perform additional studies that may be considered necessary for diagnosis.
Note: Testing requested by the referring physician (immunostains, etc) may not be performed if deemed unnecessary by the reviewing Mayo neuromuscular pathologist. Electron microscopic studies are not performed on muscle biopsy specimens. For more information see Why Electron Microscopy is Not Performed on Muscle Biopsy Specimens in Special Instructions.
See Pathology Consultation Ordering Algorithm in Special Instructions.
Specimen Type
Describes the specimen type validated for testing
Describes the specimen type validated for testing
Varies
Ordering Guidance
This test is not appropriate for inhalation-transmission diseases such as tuberculosis, Brucella, measles, and varicella zoster. This test is also not appropriate for suspected Creutzfeldt-Jacobs Disease (CJD).
Additional Testing Requirements
Biopsies from different sites require separate orders and separate specimen vials.
Necessary Information
Failure to provide this information may delay the specimen processing significantly.
1. Collection date and patient date of birth are required.
2. The name and phone number of the ordering physician and a brief history are essential to achieve a consultation fully relevant to the ordering physician's needs.
3. Muscle Histochemistry Patient Information must accompany all specimens.
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Biopsies from different sites require separate orders and separate specimen vials.
Preferred: Frozen muscle biopsy tissue
Supplies: Muscle Biopsy Kit (T541)
Specimen Type: Muscle biopsy tissue (frozen) and/or slides
Collection Instructions:
1. Prepare and transport specimen per instructions in Muscle Biopsy Specimen Preparation in Special Instructions.
2. Patient history and requests should be clearly labeled with correct patient identifiers and pathology accession/case number.
3. All specimens must be labeled with specimen type.
Additional Information: Contact the Mayo Clinic Muscle Laboratory for special problems to maximize benefit of the muscle biopsy.
Acceptable: Stained muscle biopsy slides
1. Submit all stains performed on the case.
2. All specimens must be labeled with specimen type.
Special Instructions
Library of PDFs including pertinent information and forms related to the test
Library of PDFs including pertinent information and forms related to the test
Forms
1. Muscle Histochemistry Patient Information (T361) is required, see Special Instructions.
2. Why Electron Microscopy is Not Performed on Muscle Biopsy Specimens in Special Instructions.
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory
1.5 cm biopsy
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
Identifies specimen types and conditions that may cause the specimen to be rejected
No specimen should be rejected.
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Frozen (preferred) | ||
| Ambient | |||
Useful For
Suggests clinical disorders or settings where the test may be helpful
Suggests clinical disorders or settings where the test may be helpful
Obtaining a rapid, expert opinion on muscle biopsy specimens for neuromuscular disease
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
A battery of enzyme histochemical stains will be performed on frozen tissue; additional histochemical stains or immunostains may be performed on frozen tissue; other tests can be performed as indicated and will be charged separately. The reviewing neuromuscular pathologist will determine the need for additional testing.
For all consultations, ancillary testing necessary to determine a diagnosis is ordered at the discretion of the Mayo Clinic neuromuscular pathologist. An interpretation, which includes an evaluation of the specimen and determination of a diagnosis, will be provided within a formal pathology report.
Frozen tissue sent for consultation: Appropriate additional stains may be performed at an additional charge.
Slides sent for consultation: Special stains and studies performed on the case should be sent with the case for review. In order to determine an accurate diagnosis, some of these stains or studies may be deemed to warrant repeat testing at an additional charge at the discretion of the reviewing Mayo Clinic neuromuscular pathologist. The interpreting neuromuscular pathologist may also request frozen tissue to perform additional studies that may be considered necessary for diagnosis.
Note: Testing requested by the referring physician (immunostains, etc) may not be performed if deemed unnecessary by the reviewing Mayo neuromuscular pathologist. Electron microscopic studies are not performed on muscle biopsy specimens. For more information see Why Electron Microscopy is Not Performed on Muscle Biopsy Specimens in Special Instructions.
See Pathology Consultation Ordering Algorithm in Special Instructions.
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
This consultative practice strives to bring the client the highest quality of diagnostic neuromuscular pathology, aiming to utilize only those ancillary tests that support the diagnosis in a cost-effective manner, and to provide a rapid turnaround time for diagnostic results.
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
An interpretive report will be provided.
Interpretation
Provides information to assist in interpretation of the test results
Provides information to assist in interpretation of the test results
Results are reported in a formal neuromuscular pathology report that includes diagnosis and an interpretive comment, if necessary. The formal pathology report is faxed or sent by mail according to the preference of the referring institution.
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Be aware that poor freezing and improper handling of the muscle tissue may hinder the neuromuscular pathologist's interpretation of the biopsy. It is crucial to provide a properly handled muscle specimen. In this regard, see directions for Muscle Biopsy Specimen Preparation sheet in Special Instructions. A shipping kit is available, Muscle Biopsy Kit (T541) and is recommended for collecting and shipping muscle specimens. It includes a container for the tissue, collection instructions, the Muscle Histochemistry Patient Information sheet, and a box to ship the specimen.
Clinical Reference
Recommendations for in-depth reading of a clinical nature
Recommendations for in-depth reading of a clinical nature
1. Engel AG: The muscle biopsy. In: Engel AG, Franzini-Armstrong C, eds. Myology. 3rd ed. McGraw-Hill; 2004:681-690
2. Liewluck T, Sorenson EJ, Walkiewicz MA, Rumilla KM, Milone M: Autosomal dominant distal myopathy due to a novel ACTA1 mutation. Neuromuscul Disord. 2017 Aug;27(8):742-746
3. Engel AG, Redhage KR, Tester DJ, Ackerman MJ, Selcen D: Congenital myopathy associated with the triadin knockout syndrome. Neurology. 2017 Mar 21;88(12):1153-1156
4. Niu Z, Pontifex CS, Berini S, et al: Myopathy with SQSTM1 and TIA1 variants: Clinical and pathological features. Front Neurol. 2018 Mar 19;9:147
5. Nicolau S, Liewluck T, Shen XM, Selcen D, Engel AG, Milone M: A homozygous mutation in GMPPB leads to centronuclear myopathy with combined pre- and postsynaptic defects of neuromuscular transmission. Neuromuscul Disord. 2019 Aug;29(8):614-617
6. Nicolau S, Liewluck T, Tracy JA, Laughlin RS, Milone M: Congenital myopathies in the adult neuromuscular clinic: Diagnostic challenges and pitfalls. Neurol Genet. 2019 Jun 4;5(4):e341
7. Liewluck T, Niu Z, Moore SA, Alsharabati M, Milone M: ACTA1-myopathy with prominent finger flexor weakness and rimmed vacuoles. Neuromuscul Disord. 2019 May;29(5):388-391
8. Nicolau S, Liewluck T, Elliott JL, Engel AG, Milone M: A novel heterozygous mutation in the C-terminal region of HSPB8 leads to limb-girdle rimmed vacuolar myopathy. Neuromuscul Disord. 2020 Mar;30(3):236-240
Special Instructions
Library of PDFs including pertinent information and forms related to the test
Library of PDFs including pertinent information and forms related to the test
Method Description
Describes how the test is performed and provides a method-specific reference
Describes how the test is performed and provides a method-specific reference
All requests will be processed as a consultation case first. Special studies will be performed only if deemed to be diagnostically indicated. Histochemical and immunohistochemical stains are only performed if frozen muscle biopsy tissue is provided.(Unpublished Mayo method)
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Indicates whether the report includes an additional document with charts, images or other enriched information
No
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Monday through Friday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
3 to 14 days
Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
6 months
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Indicates the location of the laboratory that performs the test
Rochester
Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their Regional Manager. For assistance, contact Customer Service.
Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
CPT codes are provided by the performing laboratory.
88342 (if appropriate)
88341 (if appropriate)
88346 (if appropriate)
88350 (if appropriate)
88305 (if appropriate)
88313 (if appropriate)
88319 (if appropriate)
88314 (if appropriate)
88321 (if appropriate)
88323 (if appropriate)
88323-26 (if appropriate)
88325 (if appropriate)
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| MBX | Muscle Path Consult | 60570-9 |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| 601767 | Interpretation | 59465-5 |
| 601769 | Participated in the Interpretation | No LOINC Needed |
| 601770 | Report electronically signed by | 19139-5 |
| 601771 | Addendum | 35265-8 |
| 601773 | Gross Description | 22634-0 |
| 601822 | Case Number | 80398-1 |
| 601911 | Disclaimer | 62364-5 |
| 603614 | Material Received | 81178-6 |
Test Setup Resources
Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.
Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.
Normal and Abnormal sample reports are provided as references for report appearance.
SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.