Test Catalog

Test Id : BHISI

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Bone Histomorphometry, Consultant Interpretation, Slides Only

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Overview

Test Catalog

Useful For
Suggests clinical disorders or settings where the test may be helpful

Identifying undetermined metabolic bone disease in submitted slide specimens

 

Diagnosing renal osteodystrophy

 

Diagnosing osteomalacia

 

Diagnosing osteoporosis

 

Diagnosing Paget disease

 

Assessing the effects of therapy

 

Identifying disorders of the hematopoietic system

 

Diagnosing aluminum toxicity

 

Identifying the presence of iron in the bone

Method Name
A short description of the method used to perform the test

Medical Interpretation

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.

No

Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

Bone HistoMorph Interp Only

Aliases
Lists additional common names for a test, as an aid in searching

Bone Histomorphometry

Histomorphometry

Bone Histo

Slide Review

Specimen Type
Describes the specimen type validated for testing

Varies

Necessary Information

Bone Histomorphometry: Patient Information (T352) must be completed and sent with the specimen. The laboratory requires this information in order to perform testing.

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Specimen Type: Bone

Source: Anterior iliac crest

Slides: 2

Submission Container/Tube: Plastic slide holder

Specimen Volume: A minimum of 1 Goldner Trichrome-stained slide and 1 hematoxylin and eosin-stained slide are required. One tetracycline slide should be submitted as applicable.

Collection Information: For complete instructions see Bone Histomorphometry Specimen Preparation (T579).

Special Instructions
Library of PDFs including pertinent information and forms related to the test

Forms

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.

See Specimen Required

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

Bone
Decalcified bone 		Reject

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Varies Ambient

Useful For
Suggests clinical disorders or settings where the test may be helpful

Identifying undetermined metabolic bone disease in submitted slide specimens

 

Diagnosing renal osteodystrophy

 

Diagnosing osteomalacia

 

Diagnosing osteoporosis

 

Diagnosing Paget disease

 

Assessing the effects of therapy

 

Identifying disorders of the hematopoietic system

 

Diagnosing aluminum toxicity

 

Identifying the presence of iron in the bone

Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Bone histomorphometry is a very sophisticated procedure utilizing full thickness bone biopsy.

 

Techniques such as 2-time interval labeling with tetracycline permit the direct measurement of the rate of bone formation. The information derived is useful in the diagnosis of metabolic bone diseases including renal osteodystrophy, osteomalacia, and osteoporosis. Other obtainable information relates to disorders such as aluminum toxicity and iron abnormalities.

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

An interpretive report will be provided.

Interpretation
Provides information to assist in interpretation of the test results

Clinical endocrinologists trained in histomorphometric techniques review and interpret the histological appearance.

 

A pathologist interprets the bone marrow from a hematoxylin and eosin-stained slide.

 

No histomorphometric values are given.

Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Mineralization or bone formation rates can be done only when tetracycline has been administered on a specific schedule prior to biopsy.

 

Biopsy site of preference is iliac crest.

Clinical Reference
Recommendations for in-depth reading of a clinical nature

1. Recker RR: Bone Histomorphometry: Techniques and Interpretation. CRC Press; 1983

2. Dempster DW, Compston JE, Drezner MK, et al. Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res. 2013;28(1):2-17. doi:10.1002/jbmr.1805

3. Chavassieux P, Chapurlat R. Interest of bone histomorphometry in bone pathophysiology investigation: Foundation, present, and future. Front Endocrinol (Lausanne). 2022;13:907914. Published 2022 Jul 28. doi:10.3389/fendo.2022.907914

Method Description
Describes how the test is performed and provides a method-specific reference

The histologic appearance of all sections is reviewed and interpreted by a clinician-histomorphometrist. A hematoxylin and eosin-stained section is reviewed for abnormalities by a pathologist. Telephone consultations with responsible physicians are carried out whenever possible.(Hodgson SF, Johnson KA, Muhs JM, et al. Outpatient percutaneous biopsy of the iliac crest: methods, morbidity, and patient acceptance. Mayo Clin Proc. 1986;61:28-33)

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday through Friday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

21 to 26 days

Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

Slides will be returned 2 weeks after result released.

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

Rochester

Fees :
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their account representative. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

Not Applicable

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

88321

LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
BHISI Bone HistoMorph Interp Only 60570-9
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
71168 Interpretation 59465-5
71169 Bone Marrow Interpretation 51628-6
71170 Participated in the Interpretation No LOINC Needed
71171 Report electronically signed by 19139-5
71172 Material Received 22633-2
71787 Case Number 80398-1
601909 Disclaimer 62364-5

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports