Identifying undetermined metabolic bone disease in submitted slide specimens
Diagnosing renal osteodystrophy
Diagnosing osteomalacia
Diagnosing osteoporosis
Diagnosing Paget disease
Assessing the effects of therapy
Identifying disorders of the hematopoietic system
Diagnosing aluminum toxicity
Identifying the presence of iron in the bone
Consultation
Varies
Bone Histomorphometry: Patient Information (T352) in Special Instructions must be completed and sent with the specimen. The laboratory requires this information in order to perform testing
Supplies: Bone Histomorphometry Specimen Preparation (T579)
Specimen Type: Bone
Source: Anterior iliac crest
Container/Tube: Slides
Collection Instructions: A minimum of 1 Goldner Trichrome-stained slide and 1 hematoxylin and eosin-stained slide are required.
Additional Information: For more information, see Bone Histomorphometry Specimen Preparation (T579) in Special Instructions.
Bone Histomorphometry: Patient Information (T352) in Special Instructions
Bone Histomorphometry Specimen Preparation (T579) in Special Instructions
Bone | Decalcified bone |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Varies | Ambient |
Identifying undetermined metabolic bone disease in submitted slide specimens
Diagnosing renal osteodystrophy
Diagnosing osteomalacia
Diagnosing osteoporosis
Diagnosing Paget disease
Assessing the effects of therapy
Identifying disorders of the hematopoietic system
Diagnosing aluminum toxicity
Identifying the presence of iron in the bone
Bone histomorphometry is a very sophisticated procedure utilizing full thickness bone biopsy.
Techniques such as 2-time interval labeling with tetracycline permit the direct measurement of the rate of bone formation. The information derived is useful in the diagnosis of metabolic bone diseases including renal osteodystrophy, osteomalacia, and osteoporosis. Other obtainable information relate to disorders such as aluminum toxicity and iron abnormalities.
The laboratory will provide an interpretive report.
Clinical endocrinologists trained in histomorphometric techniques review and interpret the histological appearance.
A pathologist interprets the bone marrow from a hematoxylin and eosin-stained slide.
No histomorphometric values are given.
Mineralization or bone formation rates can be done only when tetracycline has been administered on a specific schedule prior to biopsy.
Biopsy site of preference is iliac crest.
Recker RR: Bone Histomorphometry: Techniques and Interpretation. Boca Raton, FL, CRC Press, 1983
The histologic appearance of all sections are reviewed and interpreted by a clinician-histomorphometrist. A hematoxylin and eosin-stained section is reviewed for abnormalities by a pathologist. Telephone consultations with responsible physicians are carried out whenever possible.(Hodgson SF, Johnson KA, Muhs JM, et al: Outpatient percutaneous biopsy of the iliac crest: methods, morbidity, and patient acceptance. Mayo Clin Proc 1986;61:28-33)
Monday through Friday
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.
88321
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
BHISI | Bone HistoMorph Interp Only | 60570-9 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
71168 | Interpretation | 59465-5 |
71169 | Bone Marrow Interpretation | 51628-6 |
71170 | Participated in the Interpretation | No LOINC Needed |
71171 | Report electronically signed by | 19139-5 |
71172 | Material Received | 22633-2 |
71787 | Case Number | 80398-1 |
601909 | Disclaimer | 62364-5 |