Assessment of tissue stores of selenium
Triple-Quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
Se (Selenium)
Whole blood
This test can be used to assess tissue stores of selenium. For routine assessment of selenium deficiency or toxicity, the preferred test is selenium urine.
For assessment of recent intake, order SES / Selenium, Serum.
Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Container/Tube: Royal blue top (EDTA) plastic trace element blood collection tube
Specimen Volume: 0.8 mL
Collection Instructions:
1. See Metals Analysis Specimen Collection and Transport for complete instructions.
2. Send whole blood specimen in original tube. Do not aliquot.
0.3 mL
Gross hemolysis | OK |
Gross lipemia | OK |
Gross icterus | OK |
Microtainer | Reject |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Whole blood | Refrigerated (preferred) | 28 days | |
Ambient | 28 days | ||
Frozen | 28 days |
Assessment of tissue stores of selenium
Selenium is a naturally occurring, solid substance that is widely but unevenly distributed in the earth's crust. Selenium and its compounds are used in some photographic devices, gun bluing, plastics, paints, anti-dandruff shampoos, vitamin and mineral supplements, fungicides, and certain types of glass. Selenium is also used to prepare drugs and as a nutritional feed supplement for poultry and livestock. It is an essential element for humans and animals.
People are exposed to low levels of selenium daily through food, water, and air. Plasma and serum typically contain approximately 75% of the selenium measured in whole blood. Selenium whole blood concentrations can be used to assess tissue stores. For routine assessment of selenium deficiency or toxicity, the preferred test is selenium urine.
0-17 years: not established
> or =18 years: 150-241 ng/mL
Ultimately, any metal ion concentration value needs to be interpreted in relation to the overall clinical scenario including symptoms, physical findings, and other diagnostic results when determining further actions.
No significant cautionary statements
1. US Department of Health and Human Services: Toxicological profile for selenium. HHS: Agency for Toxic Substances and Disease Registry; 2003. Accessed July 30, 2021. Available at www.atsdr.cdc.gov/toxprofiles/tp92.pdf
2. Rifai N, Horwath AR, Wittwer CT, eds: Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018
The metal of interest is analyzed by inductively coupled plasma mass spectrometry.(Unpublished Mayo method)
Sunday
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.
84255
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
SEWB | Selenium, B | 5722-4 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
65600 | Selenium, B | 5722-4 |