Test Catalog

Test Id : CMAMA

Comprehensive Metabolic Panel, Serum

Useful For
Suggests clinical disorders or settings where the test may be helpful

Routine health monitoring

 

Patient monitoring while hospitalized for information regarding metabolism, including the current kidney status, electrolyte and acid/base balance, and blood glucose

Profile Information
A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test Id Reporting Name Available Separately Always Performed
KS Potassium, S Yes Yes
NAS Sodium, S Yes Yes
CL Chloride, S Yes Yes
HCO3 Bicarbonate, S Yes Yes
AGAP Anion Gap No Yes
BUN Bld Urea Nitrog (BUN), S Yes Yes
CRTS1 Creatinine with eGFR, S Yes Yes
CA Calcium, Total, S Yes Yes
GLURA Glucose, Random, S Yes Yes
TP Protein, Total, S Yes Yes
ALB Albumin, S Yes Yes
AST Aspartate Aminotransferase (AST), S Yes Yes
ALP Alkaline Phosphatase, S Yes Yes
ALT Alanine Aminotransferase (ALT), S Yes Yes
BILIT Bilirubin Total, S Yes Yes

Method Name
A short description of the method used to perform the test

KS, NAS, CL: Potentiometric, Indirect Ion-Selective Electrode

HCO3: Photometric/Enzymatic

AGAP: Sodium-(Bicarbonate + Chloride)

BUN: Photometric, Urease

CRTS1: Enzymatic Colorimetric Assay

CA: Photometric, 5-nitro-5'-methyl-BAPTA

GLURA: Photometric/Hexokinase

TP: Colorimetric, Biuret

ALB: Photometric, Bromcresol Green

AST: Photometric Rate, L-Aspartate with Pyridoxyl-5-Phosphate

ALP: Photometric, p-Nitrophenol Phosphate

ALT: Photometric Rate, L-Alanine with Pyridoxal-5-Phosphate

BILIT: Photometric, Diazonium Salt (DPD)

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

Comprehensive Metabolic Panel, S

Aliases
Lists additional common names for a test, as an aid in searching

CMP

Chemistry Panel

Chemistry Screen

Specimen Type
Describes the specimen type validated for testing

Serum

Necessary Information

Patient's age and sex are required.

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.6 mL

Collection Instructions:

1. Serum gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged and aliquoted within 2 hours of collection.

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory

0.5 mL

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

Gross hemolysis Reject
Gross lipemia OK

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 24 hours

Useful For
Suggests clinical disorders or settings where the test may be helpful

Routine health monitoring

 

Patient monitoring while hospitalized for information regarding metabolism, including the current kidney status, electrolyte and acid/base balance, and blood glucose

Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

The comprehensive metabolic panel measures 14 analytes and calculates an anion gap. It is used to assess kidney or liver status, electrolyte and acid/base balance, and blood glucose This comprehensive metabolic panel can also provide information about a patient's response to medications that would impact kidney or liver function.

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

SODIUM

<1 year: not established

> or =1 year: 135-145 mmol/L

 

POTASSIUM

<1 year: not established

> or =1 year: 3.6-5.2 mmol/L

 

CHLORIDE

<1 year: not established

1-17 years: 102-112 mmol/L

> or =18 years: 98-107 mmol/L

 

BICARBONATE

Males:

<1 year: not established

1-2 years: 17-25 mmol/L

3 years: 18-26 mmol/L

4-5 years: 19-27 mmol/L

6-7 years: 20-28 mmol/L

8-17 years: 21-29 mmol/L

> or =18 years: 22-29 mmol/L

 

Females:

<1 year: not established

1-3 years: 18-25 mmol/L

4-5 years: 19-26 mmol/L

6-7 years: 20-27 mmol/L

8-9 years: 21-28 mmol/L

> or =10 years: 22-29 mmol/L

 

ANION GAP

<7 years: not established

> or =7 years: 7-15

 

BLOOD UREA NITROGEN (BUN)

Males:

<12 months: not established

1-17 years: 7-20 mg/dL

> or =18 years: 8-24 mg/dL

 

Females:

<12 months: not established

1-17 years: 7-20 mg/dL

> or =18 years: 6-21 mg/dL

 

CREATININE

Males:

0-11 months: 0.17-0.42 mg/dL

1-5 years: 0.19-0.49 mg/dL

6-10 years: 0.26-0.61 mg/dL

11-14 years: 0.35-0.86 mg/dL

> or =15 years: 0.74-1.35 mg/dL

 

Females:

0-11 months: 0.17-0.42 mg/dL

1-5 years: 0.19-0.49 mg/dL

6-10 years: 0.26-0.61 mg/dL

11-15 years: 0.35-0.86 mg/dL

> or =16 years: 0.59-1.04 mg/dL

 

ESTIMATED GLOMERULAR FILTRATION RATE (eGFR)

>60 mL/min/BSA

Estimated GFR calculated using the 2009 CKD_EPI creatinine equation

 

CALCIUM

<1 year: 8.7-11.0 mg/dL

1-17 years: 9.3-10.6 mg/dL

18-59 years: 8.6-10.0 mg/dL

60-90 years: 8.8-10.2 mg/dL

>90 years: 8.2-9.6 mg/dL

 

GLUCOSE

0-11 months: not established

> or =1 year: 70-140 mg/dL

 

TOTAL PROTEIN

> or =1 year: 6.3-7.9 g/dL

Reference values have not been established for patients who are <12 months of age.

 

ALBUMIN

> or =12 months: 3.5-5.0 g/dL

Reference values have not been established for patients who are <12 months of age.

 

ASPARTATE AMINOTRANSFERASE (AST)

Males:

0-11 months: not established

1-13 years: 8-60 U/L

> or =14 years: 8-48 U/L

 

Females:

0-11 months: not established

1-13 years: 8-50 U/L

> or =14 years: 8-43 U/L

 

ALKALINE PHOSPHATASE (ALP)

Males:

4 years: 149-369 U/L

5 years: 179-416 U/L

6 years: 179-417 U/L

7 years: 172-405 U/L

8 years: 169-401 U/L

9 years: 175-411 U/L

10 years: 191-435 U/L

11 years: 185-507 U/L

12 years: 185-562 U/L

13 years: 182-587 U/L

14 years: 166-571 U/L

15 years: 138-511 U/L

16 years: 102-417 U/L

17 years: 69-311 U/L

18 years: 52-222 U/L

> or =19 years: 45-115 U/L

 

Females:

4 years: 169-372 U/L

5 years: 162-355 U/L

6 years: 169-370 U/L

7 years: 183-402 U/L

8 years: 199-440 U/L

9 years: 212-468 U/L

10 years: 215-476 U/L

11 years: 178-526 U/L

12 years: 133-485 U/L

13 years: 120-449 U/L

14 years: 153-362 U/L

15 years: 75-274 U/L

16 years: 61-264 U/L

17-23 years: 52-144 U/L

24-45 years: 37-98 U/L

46-50 years: 39-100 U/L

51-55 years: 41-108 U/L

56-60 years: 46-118 U/L

61-65 years: 50-130 U/L

> or =66 years: 55-142 U/L

Reference values have not been established for patients that are <4 years of age.

 

ALANINE AMINOTRANSFERASE (ALT)

Males:

> or =1 year: 7-55 U/L

Reference values have not been established for patients who are <12 months of age.

 

Females:

> or =1 year: 7-45 U/L

Reference values have not been established for patients who are <12 months of age.

 

TOTAL BILIRUBIN

0-6 days: Refer to http://bilitool.org/ for information on age-specific (postnatal hour of life) serum bilirubin values.

7-14 days: <15.0 mg/dL

15 days to 17 years: < or =0.9 mg/dL

>18 years: < or =1.2 mg/dL

Interpretation
Provides information to assist in interpretation of the test results

Comprehensive metabolic panel results are usually evaluated in conjunction with each other for patterns of results. The pattern of abnormal results can help identify the possible conditions or diseases present. Many conditions will cause abnormal results including kidney failure, breathing problems, and diabetes-related complications.

Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements.

Clinical Reference
Recommendations for in-depth reading of a clinical nature

AACC: Lab Tests Online: Access 03/22/2017. Available from https://labtestsonline.org/understanding/analytes/cmp

Method Description
Describes how the test is performed and provides a method-specific reference

Sodium, Potassium, Chloride:

Ion-selective electrode (ISE) (indirect potentiometry). The ISE module performs indirect measurement of electromotive force (EMF). The ISE module measures the EMF difference between an ion-selective electrode and a reference electrode. The EMF of the ion-selective electrode is dependent on the ion concentration of the sample. The EMF of the reference electrode is constant. An electronic calculation circuit converts EMF of the sample to the ion concentration of the sample.(Package insert: Roche Diagnostics ISE reagent; Indianapolis, IN, 2006)

 

Bicarbonate:

This is a photometric rate reaction. Bicarbonate (HCO3-) reacts with phosphoenolpyruvate (PEP) in the presence of phosphoenolpyruvate carboxylase (PEPC) to produce oxaloacetate and phosphate. The oxaloacetate produced is coupled with NADH in the presence of malate dehydrogenase (MDH) to produce malate and NAD. The consumption of NADH causes a decrease in absorbance and is monitored in the UV range of 320 nm to 400 nm. The rate of change is directly proportional to the concentration of bicarbonate.(Package insert: Roche Bicarbonate reagent, Indianapolis, IN, July 2000)

 

Anion Gap:

This is a calculated result. The following equation is used to calculate the anion gap (A gap):

A gap =Na - (Cl + HCO3)

 

Blood Urea Nitrogen:

This is a kinetic ultraviolet assay where urease cleaves urea to form ammonia and CO2. The ammonia formed then reacts with a-ketoglutarate and NADH in the presence of urease/glutamate dehydrogenase (GLDH) to yield glutamate and NAD. The decrease in absorbance, due to the consumption of NADH, is measured kinetically and is proportional to the amount of urea in the sample.(Package insert: Roche Urea/BUN reagent; Indianapolis, IN, Sept 2000)

 

Creatinine:

This enzymatic method is based on the conversion of creatinine with the aid of creatininase, creatinase, and sarcosine oxidase to glycine, formaldehyde and hydrogen peroxide. Catalyzed by peroxidase the liberated hydrogen peroxide reacts with 4-aminophenazone and HTIB to form a quinone imine chromogen. The color intensity of the quinone imine chromogen formed is directly proportional to the creatinine concentration in the reaction mixture.(Package insert: Roche Diagnostics, Indianapolis IN, 12/2016)

 

Calcium:

Calcium ions react with 5-nitro-5'-methyl-BAPTA (NM-BAPTA) under alkaline conditions to form a complex. This complex reacts in the second step with EDTA. The change in absorbance is directly proportional to the calcium concentration and is measured photometrically.(Package insert: Roche Calcium Gen.2 reagent, Roche Diagnostic Corp, Indianapolis, IN, 7/2012)

 

Glucose:

Glucose in the serum, in the presence of hexokinase, is converted to glucose-6-phosphate (G-6-P). In the presence of NADP, glucose-6-phosphate dehydrogenase (G-6-PDH) oxides G-6-P to gluconate-6-phosphate and NADPH. The rate of NADPH formation is directly proportional to glucose concentration in the serum and is measured photometrically.(Package insert: Roche Glucose Reagent, Indianapolis, IN, January 2000)

 

Protein, Total:

Divalent copper reacts in alkaline solution with protein peptide bonds to form the characteristic purple-colored biuret complex. Sodium potassium tartrate prevents the precipitation of copper hydroxide and potassium iodide prevents autoreduction of copper. The color intensity is directly proportional to the protein concentration, which can be determined photometrically.(Package insert: Roche Protein reagent, Roche Diagnostic Corp., Indianapolis, IN 1999)

 

Albumin:

The dye, bromcresol green (BCG), is added to serum in an acid buffer. The color intensity of the blue-green albumin-BCG complex is directly proportional to the albumin concentration and is determined photometrically.(Package insert: Roche Albumin reagent; Roche Diagnostic Corp., Indianapolis, IN, July 1999)

 

Aspartate Aminotransferase:

Aspartate aminotransferase (AST) is measured by a coupled enzyme kinetic method where the rate of decrease of NADH, determined at 340 nm, is directly proportional to the AST activity.(Package insert: Roche AST reagent, Indianapolis, IN, January 2000)

 

Alkaline Phosphatase:

In the presence of magnesium and zinc ions, p-nitrophenyl phosphate is cleaved by phosphatases into phosphate and p-nitrophenol. The p-nitrophenol released is directly proportional to the catalytic alkaline phosphatase activity. It is determined by measuring the increase in absorbance.(Package insert: Roche Alkaline Phosphatase reagent, Indianapolis, IN, February 2012)

 

Alanine Aminotransferase:

Alanine aminotransferase (ALT) activity is determined by a kinetic method using a coupled enzyme reaction where the rate of NADH consumption is measured at 340 nm. The NADH decrease is directly proportional to the ALT activity.(Package insert: Roche ALT reagent, Indianapolis, IN, January 2000)

 

Bilirubin, Total:

Total bilirubin, in the presence of a suitable solubilizing agent, is coupled with 3,5-dichlorophenyl diazonium in a strongly acidic medium. The color intensity of the red azo dye formed is directly proportional to the total bilirubin and can be determined photometrically.(Package insert: Bilirubin Total Gen. 3, Roche Diagnostics, Indianapolis, IN, July 2014)

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday through Sunday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

Same day/1 to 2 days

Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

1 week

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

Rochester

Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their Regional Manager. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

KS-84132

NAS-84295

CL-82435

HCO3-82374

AGAP-NA

BUN-84520

CRTS1-82565

CA-82310

GLURA-82947

TP-84155

ALB-82040

AST-84450

ALP-84075

ALT-84460

BILIT-82247

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports