Test Catalog

Test ID: ECULI    
Eculizumab, Serum

Specimen Type Describes the specimen type validated for testing


Ordering Guidance

Therapeutic drug monitoring of eculizumab may be useful when assessing response to therapy is difficult or patients need to be above a certain therapeutic monoclonal antibody (mAb) concentration in order to improve the odds of a clinical response for therapy optimization, including potential dose de-escalation or discontinuation of therapy in remission states. Pharmacodynamic studies of complement blockage are also common, see ECUMP / Eculizumab Monitoring Panel, Serum for more information on related testing.

Specimen Required Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Patient Preparation: Pembrolizumab/Keytruda must be discontinued at least 4 weeks prior to testing for eculizumab quantitation in serum.


Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 1 mL

Collection Instructions:

1. Draw blood immediately before next scheduled dose.

2. Spin down within 2 hours of draw.


If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Renal Diagnostics Test Request (T830)

-Coagulation Test Request (T753)

Specimen Minimum Volume Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory

0.5 mL

Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus OK

Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen TypeTemperatureTimeSpecial Container
SerumRefrigerated (preferred)28 days
 Frozen 30 days
 Ambient 4 days