Test Catalog

Test ID: FFTRP    
Trofile Co-Receptor Tropism Assay

Method Description Describes how the test is performed and provides a method-specific reference

Co-receptor tropism is defined as an interaction of a virus with a specific co-receptor on the target cell. To gain entry into

CD4+ cells, HIV must bind to the cell surface CD4 receptor and to one of two co-receptors, CCR5 or CXCR4.


Trofile is a cell-based approach to determine a patient’s HIV co-receptor tropism (or “Tropotype™). Trofile uses the complete gp160 coding region of the HIV-1 envelope protein ensuring that all of the determinants of tropism are tested. CLIA validation experiments demonstrate that Trofile is 100% sensitive at detecting 0.3% CXCR4-using minor variants.


This class of drugs binds to CCR5 and blocks CCR5-mediated HIV entry into host cells. Trofile is used to determine whether a CCR5 antagonist may be an appropriate drug for a patient. Several clinical trials on CCR5 antagonists have demonstrated the positive and negative predictive value of Trofile in clinical settings.


PDF Report Indicates whether the report includes an additional document with charts, images or other enriched information


Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.

Monday through Friday

Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.

18 - 21 days

Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Clinic Laboratories until the release of the test result

22 - 23 days

Performing Laboratory Location Indicates the location of the laboratory that performs the test

Monogram Biosciences, Inc