Test Catalog

Test ID: ARBI    
Acetylcholine Receptor (Muscle AChR) Binding Antibody, Serum

Method Description Describes how the test is performed and provides a method-specific reference

Acetylcholine receptors (a mixture of adult and fetal type) are solubilized from human limb muscle in nonionic detergent and complexed with (125)I-labeled alpha-bungarotoxin to provide antigen. After incubation with patient's serum, an excess of goat-antihuman IgG and IgM is added. Acetylcholine receptor-(125)I-alpha-bungarotoxin complexes to which antibodies have bound will coprecipitate with the total human immunoglobulin. The radioactivity of the washed pellet is determined. All positive results are verified by ruling out false-positive binding of immunoglobulin to (125)I-alpha-bungarotoxin, such as might occur in patients with immune complex disorders or subjects exposed to snake venom products.(Griesmann GE, Kryzer TJ, Lennon VA: Autoantibody profiles of myasthenia gravis and Lambert-Eaton myasthenic syndrome. In Manual of Clinical and Laboratory Immunology. Sixth edition. Edited by NR Rose, RG Hamilton, et al. Washington, DC, ASM Press 2002, pp 1005-1012. Waters P, Pettingill P, Lang B:  Detection methods for neural autoantibodies. Handb Clin Neurol. 2016;133:147-63)

PDF Report Indicates whether the report includes an additional document with charts, images or other enriched information


Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.

Monday through Friday; 11 a.m., 6 p.m., 10 p.m.

Saturday; 6 a.m.

Sunday; 6 a.m., 10 a.m.

Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.

3 days

Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Clinic Laboratories until the release of the test result

6 days

Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

28 days

Performing Laboratory Location Indicates the location of the laboratory that performs the test