Web: | mayocliniclabs.com |
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Email: | mcl@mayo.edu |
Telephone: | 800-533-1710 |
International: | +1 855-379-3115 |
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Genomic DNA from whole blood or cord blood is digested with Ksp 22 I restriction enzyme, ligated with T4 DNA ligase, and amplified by PCR with primers specific for the F8 intron 22 inversion mutations.(Rosetti LC, Radic CP, Larripa IB, De Brasi CD: Developing a new generation of tests for genotyping hemophilia-causative rearrangements involving int22h and int1h hotspots in the factor VIII gene. J Thromb Haemost 2008;6:830-836; Meijer P, Verbruggen, Spannagi M: Clotting factors and inhibitors: Assays and Interpretation. Chapter 33. In Laboratory Hematology Practice. Edited by K Kottke-Marchant. Wiley Blackwell Publishing. 2012, pp 435-446)
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