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The immunoassay utilizes frataxin-specific monoclonal antibodies bound to Luminex microspheres as capture antibodies and biotinylated frataxin-specific polyclonal antibodies as detection antibodies. Streptavidin-phycoerythrin attaches to the biotin and when exposed to light at 352 nM emits a photon that is measured and that signal is used to determine the amount of frataxin in the sample.(Deutsch EC, Santani AB, Perlman SL, et al: A rapid, noninvasive immunoassay for frataxin: utility in assessment of Friedreich ataxia. Mol Genet Metab. 2010 Oct-Nov;101(2-3):238-245 doi:10.1016/j.ymgme.2010.07.001; Cowan T, Pasquali M: Laboratory investigations of inborn errors of metabolism. In: Sarafoglou K, Hoffman GF, Roth KS, eds. Pediatric Endocrinology and Inborn Errors of Metabolism. 2nd ed. McGraw-Hill; 2017:1139-1158)
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