Test Catalog

Test ID: DRVI4    
Dilute Russell Viper Venom Time (DRVVT) Interpretation

Method Description Describes how the test is performed and provides a method-specific reference

The dilute Russell viper venom time (DRVVT) screening assay is performed on the Instrumentation Laboratory ACL TOP. Patient plasma is incubated for a specified time then combined with a DRVVT screening reagent containing Russell's viper venom, phospholipids, heparin neutralizing agents, calcium, buffers and stabilizers to trigger the coagulation process. Subsequently, the time to clot formation is measured optically using a wavelength of 671 nm. The patient DRVVT screening clotting time is normalized by dividing the patient result by the mean DRVVT screening clotting time of normal pooled plasma to yield a ratio (DRVVT screen ratio).


Patient samples with a prolonged DRVVT (DRVVT screen ratio > or =1.20) are further studied by adding an equal volume of normal pooled plasma (platelet-depleted) and repeating the DRVVT test procedure, with mathematical normalization, to yield the DRVVT mix (1:1) ratio and the DRVVT test using DRVVT confirmatory reagent (enriched in phospholipid), and results are expressed as the quotient obtained from dividing the patient DRVVT screening clotting time by the patient DRVVT confirmatory clotting time (DRVVT confirm ratio).(Thiagarajan P, Pengo V, Shapiro SS: The use of the dilute Russell viper venom time for the diagnosis of lupus anticoagulants. Blood Oct1986;68(4):869-874; Package insert: LA CHECK DRVVT Precision Biologic, Dartmouth, Nova Scotia, Canada. March 2012; Package insert: LA SURE DRVVT Precision Biologic, Dartmouth, Nova Scotia, Canada. March 2012)

PDF Report Indicates whether the report includes an additional document with charts, images or other enriched information


Day(s) Performed Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday through Friday

Report Available The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

2 days

Performing Laboratory Location Indicates the location of the laboratory that performs the test