Referred Tests
| Web: | mayocliniclabs.com |
|---|---|
| Email: | mcl@mayo.edu |
| Telephone: | 800-533-1710 |
| International: | +1 855-379-3115 |
| Values are valid only on day of printing. | |
Test ID: CRDPU
Creatine Disorders Panel, Random, Urine
Useful For 
Suggests clinical disorders or settings where the test may be helpful
Evaluation of patients with a clinical suspicion of inborn errors of creatine metabolism including arginine:glycine amidinotransferase deficiency, guanidinoacetate methyltransferase deficiency, and creatine transporter (SLC6A8) defect
Highlights
Depletion of cerebral creatine occurs in all 3 types of creatine deficiency syndromes (CDS): arginine:glycine amidinotransferase (AGAT) deficiency, guanidinoacetate methyltransferase (GAMT) deficiency, and creatine transporter (SLC6A8) deficiency.
Measurement of guanidinoacetate (GAA), creatine (Cr), and creatinine (Crn) in urine along with the Cr:Crn ratio distinguishes among the types of creatine deficiency syndromes.
Treatment with oral creatine supplementation is effective in some types of CDS.
Creatine supplementation may cause increased creatine values.
Additional Tests Lists tests that are always performed, at an additional charge, with the initial tests.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| CRBO | Creatine, (Bill Only), U | No | Yes |
| CRNBO | Creatinine, (Bill Only), U | No | Yes |
| GAABO | Guanidinoacetate, (Bill Only), U | No | Yes |
Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
CRDPU / Creatine Disorders Panel, Urine is a single test that carries the results for the panel. When the test is resulted, the following procedures are billed:
-CRBO / Creatine, Urine (Bill Only)
-CRNBO / Creatinine, Urine (Bill Only)
-GAABO / Guanidinoacetate, Urine (Bill Only)
For more information, see Newborn Screening Act Sheet Guanidinoacetate Methyltransferase Deficiency: Increased Guanidinoacetate in Special Instructions.
The following algorithms are available in Special Instructions:
-Newborn Screen Follow-up for Guanidinoacetate Methyltransferase Deficiency (GAMT)
-Epilepsy: Unexplained Refractory and/or Familial Testing Algorithm
Special Instructions Library of PDFs including pertinent information and forms related to the test
Method Name A short description of the method used to perform the test
Liquid Chromatography-Tandem Mass Spectometry (LC-MS/MS)
NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name Lists a shorter or abbreviated version of the Published Name for a test
Aliases Lists additional common names for a test, as an aid in searching
Arginine:Glycine Amidinotransferase Deficiency (AGAT)
CrT1 defect
GAMT (Guanidinoacetate Methyltransferase) Deficiency
Guanidinoacetate Methyltransferase (GAMT) Deficiency
Guanidinoacetate
Guanidinoacetic acid
Creatine urine
Creatinine urine
Creatine/creatinine ratio urine
Creatine disorders