Test Id : CNSA
Central Nervous System Consultation, Autopsy, Varies
Useful For
Suggests clinical disorders or settings where the test may be helpful
Evaluation of congenital neurological disease
Evaluation of neurodegenerative disease
Evaluation of cases with a complex neurological or neurosurgical history
Evaluation of sudden unexplained death
This test is not intended for cases under litigation without preauthorization.
Reflex Tests
Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.
| Test Id | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| NERPC | Necropsy, regional | No | No |
| NESPC | Necropsy, single organ | No | No |
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
When only a brain is submitted, NESPC / Necropsy, single organ (Bill Only) will be charged.
When both a brain and spinal cord are submitted, NERPC / Necropsy, regional (Bill Only) will be charged.
Method Name
A short description of the method used to perform the test
Stain
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Aliases
Lists additional common names for a test, as an aid in searching
Alzheimer's Disease
Brain autopsy
CNSA
Creutzfeld-Jakob disease (CJD)
Dementia
Neurodegenerative disease
Parkinson's Disease
Brain donation
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
When only a brain is submitted, NESPC / Necropsy, single organ (Bill Only) will be charged.
When both a brain and spinal cord are submitted, NERPC / Necropsy, regional (Bill Only) will be charged.
Specimen Type
Describes the specimen type validated for testing
Varies
Shipping Instructions
Ship specimen using the Central Nervous System Consult Kit (T633).
Necessary Information
It is imperative that detailed clinical information and, when possible, operative notes and radiographs accompany the specimen.
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Hematoxylin-and-eosin stained sections are also acceptable, but must be accompanied by paraffin blocks and/or remaining wet tissue.
In cases submitted as part of a research protocol, contact 507-284-3887 for further guidance.
Supplies: Central Nervous System Consult Kit (T633)
Sources: Brain (and spinal cord when indicated)
Container/Tube: Plastic container
Specimen Volume: 1 cm(3) cube
Collection Instructions:
1. Take a small (1 cm[3]) cube of brain from 1 of the frontal lobes (typically, right inferior frontal).
2. Wrap in aluminum foil and place in plastic container.
3. Label container with identifying information (ie, patient name, date of birth, autopsy number, and date of collection).
4. Freeze and store in a -70 degrees C freezer.
5. Place the remaining brain in 10% formalin if non-Creutzfeldt-Jakob disease (CJD), and 15% formalin for suspected cases of CJD, suspended by a thread under the basilar artery and fixed for 7 to 10 days.
Additional Information: Upon completion of consultation, the brain tissue will be stored 10 years in the Mayo Clinic Tissue Registry. The Mayo Clinic policy precludes our evaluation of cases under litigation that involve non-Mayo Clinic patients.
Special Instructions
Library of PDFs including pertinent information and forms related to the test
Forms
The following are available:
-Submitting Non-Protocol Autopsy Brain/Spinal Cord for Examination
OR
-Submitting Brain for Neuropathologic Examination: Cases Suspected of Creutzfeldt-Jakob Disease (CJD)
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.
Entire collection
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Ambient (preferred) | ||
| Refrigerated | |||
| Frozen | |||
Useful For
Suggests clinical disorders or settings where the test may be helpful
Evaluation of congenital neurological disease
Evaluation of neurodegenerative disease
Evaluation of cases with a complex neurological or neurosurgical history
Evaluation of sudden unexplained death
This test is not intended for cases under litigation without preauthorization.
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
When only a brain is submitted, NESPC / Necropsy, single organ (Bill Only) will be charged.
When both a brain and spinal cord are submitted, NERPC / Necropsy, regional (Bill Only) will be charged.
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Difficult neurological abnormalities, including congenital anomalies, sometimes require the assistance of a neuropathologist. This evaluation is offered to provide the careful dissection and diagnostic experience that may be needed for unusual or rare neuropathological cases.
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
An interpretive report will be provided.
Interpretation
Provides information to assist in interpretation of the test results
This request will be processed as a consultation. Appropriate stains will be performed, and a diagnostic interpretation provided.
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Specimens should be completely fixed in formalin for 7 to 10 days, prior to shipping.
It is best if specimen is not dissected prior to shipment.
Clinical Reference
Recommendations for in-depth reading of a clinical nature
1. Collins KA, Powers JM: Autopsy procedures for the brain, spinal cord, and neuromuscular system. In: Collins KA, Hutchins GM, eds. Autopsy Performance and Reporting. 2nd ed. College of American Pathologists; 2003:chap 20
2. Crain BJ, Mirra SS: The autopsy in cases of Alzheimer's Disease and other dementias. In: Collins KA, Hutchins GM, eds. Autopsy Performance and Reporting. 2nd ed. College of American Pathologists; 2003:chap 21
Method Description
Describes how the test is performed and provides a method-specific reference
Giannini C, Okazaki H: Nervous system. In Waters BL, ed. Handbook of Autopsy Practice. 4th ed. Humana Press; 2009:chap 4
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Monday through Friday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees :
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their account representative. For assistance, contact Customer Service.
Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
Not Applicable
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
CPT codes are provided by the performing laboratory.
88037 (if appropriate)
88036 (if appropriate)
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| CNSA | Neuropathology Consult | 18743-5 |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| 71070 | Interpretation | 18743-5 |
| 71071 | Participated in the Interpretation | No LOINC Needed |
| 71072 | Report electronically signed by | 19139-5 |
| 71073 | Addendum | 35265-8 |
| 71074 | Gross Description | 22634-0 |
| 71075 | Material Received | 22633-2 |
| 71589 | Disclaimer | 62364-5 |
| 71795 | Case Number | 80398-1 |