Test Catalog

Test ID: TLYM    
T-Cell Lymphoma, FISH, Tissue

Useful For Suggests clinical disorders or settings where the test may be helpful

Detecting a neoplastic clone associated with the common chromosome abnormalities seen in patients with various T-cell lymphomas


Tracking known chromosome abnormalities and response to therapy in patients with T-cell lymphomas


Providing potentially prognostic information in patients with documented systemic anaplastic lymphoma kinase-negative anaplastic large cell lymphoma


Supporting the diagnosis of peripheral T-cell lymphoma when coordinated with consultation by anatomic pathology

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
_PRAHProbe, Each Additional (TLYM)No, (Bill Only)No

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test does not include a pathology consultation. If a pathology consultation is requested, PATHC / Pathology Consultation should be ordered and the appropriate FISH test will be ordered and performed at an additional charge. Mayo Hematopathology Consultants are involved in both the pre-analytic (tissue adequacy and probe selection, when applicable) and post-analytic (interpretation of FISH results in context of specific case, when applicable) phases.


A charge and CPT code is applied for each probe set hybridized, analyzed, and reported.


Depending on the lymphoma subtype suspected, the most appropriate probes to order are listed in the Clinical Information.


If the patient is being tracked for known abnormalities, indicate which probes should be used.


Panel includes testing for the following abnormalities using the probes listed:

14q32.1 rearrangement, TCL1A

14q11.2 rearrangement, TRAD

-7/7q-/i(7q), D7S486/D7Z1

+8, D8Z2/MYC

2p23.2 rearrangement, ALK

3q28 rearrangement, TP63 and TBL1XR1/TP63 (only performed when necessary to resolve or confirm TP63 rearrangement concerns)

6p25.3 rearrangement, IRF4 (DUSP22

Method Name A short description of the method used to perform the test

Fluorescence In Situ Hybridization (FISH)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

T-cell Lymphoma, FISH, Tissue

Aliases Lists additional common names for a test, as an aid in searching

+8 (trisomy 8)
ALK (2p23) rearrangement
Hepatosplenic T-Cell Lymphoma
inv(14) - inversion 14
Iso(7q) - isochromosome 7q
T-cell Prolymphocytic Leukemia (T-PLL)
TCL1A (14q32) rearrangement
IRF4 (6p25.3) rearrangement
Anaplastic large cell lymphoma
TP63 (3q28) rearrangement
TBL1XR1/TP63 (3q28) rearrangement
TRAD (14q11.2) rearrangement