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Test ID: H2MT    
HER2 Amplification, Miscellaneous Tumor, FISH, Tissue

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Useful For Suggests clinical disorders or settings where the test may be helpful

Guiding cancer therapy, as patients with HER2 amplification may be candidates for therapies that target the human epidermal growth factor receptor 2 (HER2) protein (eg, trastuzumab [Herceptin], pertuzumab)

 

Confirming the presence of HER2 amplification in cases with 2+ (low level) or 3+ (high level) HER2 protein overexpression by immunohistochemistry

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test does not include a pathology consult. If a pathology consult is requested, PATHC / Pathology Consultation should be ordered and the appropriate FISH test will be ordered and performed at an additional charge.

 

A charge and CPT code is applied for each probe set hybridized, analyzed, and reported.

 

NOTE: in accordance to criteria set forth in the 2013 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guideline for breast cancer, reflex testing will not be performed using the alternative chromosome 17 probe when the FISH result is equivocal.

Method Name A short description of the method used to perform the test

Fluorescence In Situ Hybridization (FISH)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

HER2, Misc. Tumor, FISH, Tissue

Aliases Lists additional common names for a test, as an aid in searching

c-erb-b2 Amplification Test