TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: TLBLF    
T-Lymphoblastic Leukemia/Lymphoma, FISH, Tissue

Useful For Suggests clinical disorders or settings where the test may be helpful

Detecting a neoplastic clone associated with the common chromosome abnormalities seen in patients with T-cell lymphoblastic leukemia or lymphoma

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
_I300Interphases, >=100 NoNo
_I099Interphases, 25-99NoNo
_IL25Interphases, <25NoNo
_PB03Probe, +3NoNo
_PB02Probe, +2NoNo
_PADDProbe, +1NoNo
_PBCTProbe, +2NoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test may be ordered in 2 distinct ways allowing different combinations of probes to be utilized based on the clinical question, including the standard (diagnostic) TLBL FISH panel and the individual TLBL FISH probes (per client request).

 

The specific TLBL FISH panel or probes requested must be noted on the request form or in the reason for referral. If no specific panel or FISH probes are indicated, the standard (diagnostic) panel will be performed.

 

The standard (diagnostic) panel includes testing for the following abnormalities, using the FISH probes listed:

-1p33 rearrangements, TAL1/STIL(SIL)

-t(5;14)(q35;q32), TLX3(HOX11L2)/BCL11B

-7q34 rearrangements, TRB(TCR beta)

-9p-, CDKN2A(p16)/D9Z1

-t(9;22)(q34;q11.2), ABL1 amplification, ABL1(ABL)/BCR

-t(10;11)(p12;q14), MLLT10(AF10)/PICALM

-11q23 rearrangements, MLL

-14q11.2 rearrangements, TRAD (TCR alpha delta)

-17p-, TP53/D17Z1

 

When an MLL rearrangement is identified, reflex testing will be performed with 1 or more dual-fusion probe sets (D-FISH) in an attempt to identify the translocation partner. Probes include:

-t(4;11)(q21;q23), AFF1(AF4)/MLL

-t(6;11)(q27;q23), MLLT4(AF6)/MLL

-t(9;11)(p22;q23), MLLT3(AF9)/MLL

-t(10;11)(p12;q23), MLLT10(AF10)/MLL

-t(11;19)(q23;p13.1), MLL/ELL

-t(11;19)(q23;p13.3), MLL/MLLT1(ENL)

 

When an TRB(TCR beta) rearrangement is identified, reflex testing will be performed with a dual-fusion probe sets

(D-FISH) in an attempt to identify the translocation partner.

-t(7;10)(q34;q24), TRB(TCR beta)/TLX1(HOX11)

 

When an TRAD(TCR alpha delta) rearrangement is identified, reflex testing will be performed with a dual-fusion probe sets

(D-FISH) in an attempt to identify the translocation partner.

-t(10;14)(q24;q11.2), TLX1(HOX11)/TRAD(TCR alpha delta)

 

This test includes a charge for application of the first probe set (2 FISH probes) and professional interpretation of results. Additional charges will be incurred for all reflex probes performed. Analysis charges will be incurred based on the number of cells analyzed per probe set. If no cells are available for analysis, no analysis charges will be incurred.

Method Name A short description of the method used to perform the test

Fluorescence In Situ Hybridization (FISH)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

T-Lymphoblastic Leuk/Lymph, FISH,Ts

Aliases Lists additional common names for a test, as an aid in searching

ABL amplification
ABL/BCR
ABL1 amplification
ABL1/BCR
AF10/PICALM
CDKN2A/Cen9
Deletion 1p32
Deletion 9p
HOX11L2/BCL11B
KMT2A
MLL
p16
p16/D9Z1
SIL/TAL1
t(10;11)(p13;q14) (MLLT10/PICALM)
t(10;11)(p13;q23) (AF10/MLL)
t(10;11)(p13;q23) (MLLT10/MLL)
t(10;14)(q24;q11.2) (HOX11/TCRAD)
t(10;14)(q24;q11.2) (TLX1/TRAD)
t(11;19)(q23;p13.1) (MLL/ELL)
t(11;19)(q23;p13.3) (MLL/ENL)
t(11;19)(q23;p13.3) (MLL/MLLT1)
t(11q23;var)
t(14q11.2;var)
t(4;11)(q21;q23) (AF4/MLL)
t(4;11)(q21;q23) (AFF1/MLL)
t(5;14)(q35;q32)
t(6;11)(q27;q23) (AF6/MLL)
t(6;11)(q27;q23) (MLLT4/MLL)
t(7;10)(q32;q24) TCRB/HOX11
t(7;10)(q32;q24) TRB/TLX1
t(7q34;var)
t(9;11)(p22;q23) (AF9/MLL)
t(9;11)(p22;q23) (MLLT3/MLL)
t(9;22)(q34;q11.2)
TAL1/STIL
T-cell receptor alpha/delta
T-cell receptor beta
TCRAD
TCRalpha/delta
TCRB
TCRbeta
TLX3/BCL11B
TP53
TRB