Test Catalog

Test ID: ADALX    
Adalimumab Quantitative with Reflex to Antibody, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Detection and quantification of antibodies directed against adalimumab in serum

 

Trough level quantitation for evaluation of patients with loss of response to adalimumab

Highlights

Adalimumab (tradename Humira, manufactured by AbbVie) is a fully human therapeutic monoclonal antibody targeting tumor necrosis factor alpha (TNF), a proinflammatory cytokine that is upregulated in several autoimmune inflammatory states.

 

Adalimumab is FDA-approved for treatment of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis; ankylosing spondylitis, pediatric and adult Crohn disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa and uveitis. Adalimumab is a subcutaneous injection, usually self-administered every other week at a fixed dose of 40 mg in adults, although dosing can vary.

 

Testing for adalimumab concentration and presence of antiadalimumab antibodies is helpful to adjust therapeutic strategies for patients starting therapy (proactive monitoring), and to adjust dosing when partial response or loss of response to therapy is observed, manifested as recurrence of symptoms.

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
ADLABAdalimumab Ab, SNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

If the result is 5.0 mcg/mL or less, then adalimumab antibody test will be performed at an additional charge.

Method Name A short description of the method used to perform the test

ADALX, ADLAB: Enzyme-Linked Immunosorbent Assay (ELISA)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Adalimumab QN with Reflex to Ab, S

Aliases Lists additional common names for a test, as an aid in searching

Humira