Test Catalog

Test ID: CXLPL    
CXCR4 Mutation Analysis, Somatic, Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia

Useful For Suggests clinical disorders or settings where the test may be helpful

Prognostication and clinical management of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test is intended to detect gene mutations within the C-terminus end of the CXCR4 gene that are commonly found in association with MYD88 L265P mutations in cases of Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia (LPL/WM).


CXCR4 mutations are identified in approximately 30% to 40% of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM) and are almost always in association with MYD88 L265P, which is highly prevalent in this neoplasm. The status of CXCR4 mutations in the context of MYD88 L265P is clinically relevant as important determinants of clinical presentation, overall survival, and therapeutic response to ibrutinib. This test can aid in the prognostication and therapeutic management of LPL/WM. It offers highly sensitive detection of the well-characterized hotspot mutations c.1013C->G/A, p.S338X and routine Sanger sequencing for other mutations in the C-terminus region. It is strongly recommended that this test be used in the context of the MYD88 / MYD88, L265P, Somatic Gene Mutation, DNA Allele-Specific PCR assay during evaluation of LPL/WM.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Mutation Detection in DNA Using BNAClamp Sanger Sequencing Technology and Routine Sanger Sequencing

(BNAClamp is utilized pursuant to a license agreement with BNA Inc)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

CXCR4 Mutation in B-cell Lymphoma

Aliases Lists additional common names for a test, as an aid in searching

B-cell lymphoma
Lymphoplasmacytic lymphoma
Waldenstrom Macroglobulinemia