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Test ID: CXLPL    
CXCR4 Mutation Analysis, Somatic, Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia, Varies

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Useful For Suggests clinical disorders or settings where the test may be helpful

Aiding in the prognostication and clinical management of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test detects gene variants within the C-terminal end of the CXCR4 gene that are commonly found in association with MYD88 L265P variants in cases of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM).

Highlights

This test offers highly sensitive detection of the well-characterized hotspot variants c.1013C->G/A, p.S338X and routine Sanger sequencing for other variant in the C-terminus region. It is strongly recommended that this test be used in the context of the MYD88 / MYD88, L265P, Somatic Gene Mutation, DNA Allele-Specific PCR assay during evaluation of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM).

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Mutation Detection in DNA using BNAClamp Sanger Sequencing Technology and Routine Sanger Sequencing

(BNAClamp is utilized pursuant to a license agreement with BNA Inc)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

CXCR4 Mutation in B-cell Lymphoma

Aliases Lists additional common names for a test, as an aid in searching

B-cell lymphoma
LPL/WM
Lymphoplasmacytic lymphoma
CXCR4
Waldenstrom Macroglobulinemia
S338X
LPLFX