Web: | mayocliniclabs.com |
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Email: | mcl@mayo.edu |
Telephone: | 800-533-1710 |
International: | +1 855-379-3115 |
Values are valid only on day of printing. |
Evaluating chronic lymphocytic leukemia patients at diagnosis or during disease course for the presence of TP53 gene variants indicating high risk of disease progression and adverse outcomes
This test is not intended for the evaluation of patients suspected of having an inherited or germline TP53 cancer syndrome (eg, Li Fraumeni syndrome)
This test is complementary to fluorescence in situ hybridization (FISH) analysis for the 17p- abnormality but more appropriately identifies the presence of variant alteration and gene inactivation in tumor cells.
Test ID | Reporting Name | Available Separately | Always Performed |
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CSP53 | TP53 Pre-Analysis Cell Sorting, V | No | No |
Flow cytometry will be performed on peripheral blood samples to verify diagnosis of chronic lymphocytic leukemia (CLL) and to selectively enrich for B-cells in samples with a clonal population.
See TP53 Sequencing Testing Algorithm in Special Instructions.
Polymerase Chain Reaction (PCR) and Sanger Sequencing