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Test ID: LPLFX    
Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia (LPL/WM), MYD88 L265P with Reflex to CXCR4, Varies

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Useful For Suggests clinical disorders or settings where the test may be helpful

Establishing the diagnosis of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM)

 

Helping distinguish LPL/WM low-grade B-cell lymphoma from other subtypes

 

Aiding in the prognostication and clinical management of LPL/WM

Highlights

This test offers highly sensitive detection of the well-characterized hotspot variants c.1013C->G/A, p.S338X and routine Sanger sequencing for other variants in the C-terminus region.

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
CXCFXCXCR4, Gene Mutation, ReflexNo, (bill only)No

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

The algorithm starts with the sensitive MYD88 L265P testing by allele-specific polymerase chain reaction (PCR.) If a MYD88 L265P variant is detected, additional CXCR4 testing will be performed. If a MYD88 L265P variant is not detected, the algorithm ends and no further testing is necessary.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Allele-Specific Polymerase Chain Reaction (AS-PCR), Bridged Nucleic Acids (BNA) Clamp Sanger Sequencing and Routine Sanger Sequencing

(BNAClamp is utilized pursuant to a license agreement with BNA Inc.)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Reflex Testing of MYD88 and CXCR4

Aliases Lists additional common names for a test, as an aid in searching

B-cell lymphoma
L265P
LPL/WM
Lymphoplasmacytic lymphoma
MYD88
CXCR4
Waldenstrom Macroglobulinemia
CXLPL
S338X