Web: | mayocliniclabs.com |
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Email: | mcl@mayo.edu |
Telephone: | 800-533-1710 |
International: | +1 855-379-3115 |
Values are valid only on day of printing. |
Establishing the diagnosis of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM)
Helping distinguish LPL/WM low-grade B-cell lymphoma from other subtypes
Aiding in the prognostication and clinical management of LPL/WM
This test offers highly sensitive detection of the well-characterized hotspot variants c.1013C->G/A, p.S338X and routine Sanger sequencing for other variants in the C-terminus region.
Test ID | Reporting Name | Available Separately | Always Performed |
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CXCFX | CXCR4, Gene Mutation, Reflex | No, (bill only) | No |
The algorithm starts with the sensitive MYD88 L265P testing by allele-specific polymerase chain reaction (PCR.) If a MYD88 L265P variant is detected, additional CXCR4 testing will be performed. If a MYD88 L265P variant is not detected, the algorithm ends and no further testing is necessary.
Allele-Specific Polymerase Chain Reaction (AS-PCR), Bridged Nucleic Acids (BNA) Clamp Sanger Sequencing and Routine Sanger Sequencing
(BNAClamp is utilized pursuant to a license agreement with BNA Inc.)