Web: | mayocliniclabs.com |
---|---|
Email: | mcl@mayo.edu |
Telephone: | 800-533-1710 |
International: | +1 855-379-3115 |
Values are valid only on day of printing. |
Diagnosis of methemoglobinemia and sulfhemoglobinemia and possible hereditary (congenital) causes
Differentiation of methemoglobinemia and sulfhemoglobinemia from other causes of cyanosis (eg, congenital heart disease)
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
MEVI | Methemoglobinemia Interpretation | No | Yes |
HGBCE | Hb Variant, A2 and F Quantitation,B | Yes | Yes |
HPLC | HPLC Hb Variant, B | No | Yes |
METH | Methemoglobin, B | Yes, (Order MET) | Yes |
SULF | Sulfhemoglobin, B | Yes, (Order MET) | Yes |
METR1 | Cytochrome b5 Reductase, B | Yes | Yes |
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
SDEX | Sickle Solubility, B | Yes | No |
IEF | Isoelectric Focusing, B | No | No |
MASS | Hb Variant by Mass Spec, B | No | No |
UNHB | Hb Stability, B | No | No |
HPFH | Hb F Distribution, B | No | No |
ATHAL | Alpha-Globin Gene Analysis | Yes | No |
WASQR | Alpha Globin Gene Sequencing, B | Yes, (Order WASEQ) | No |
WBSQR | Beta Globin Gene Sequencing, B | Yes, (Order WBSEQ) | No |
WBDDR | Beta Globin Cluster Locus Del/Dup,B | Yes, (Order WBDD) | No |
WGSQR | Gamma Globin Full Gene Sequencing | No | No |
MEV0 | Methemoglobin Summary Interp | No | No |
This is a consultative evaluation in which the case will be evaluated at Mayo Clinic Laboratories, the appropriate tests performed at an additional charge, and the results interpreted. This is an evaluation for methemoglobin and sulfhemoglobin levels and possible hereditary causes. Methemoglobin, sulfhemoglobin levels, cytochrome-b5 reductase (methemoglobin reductase) activity, and protein analysis screening for hemoglobin (Hb) variants (capillary electrophoresis, cation exchange high performance liquid chromatography [HPLC] and capillary electrophoresis) will always be performed. If additional hemoglobin variant confirmatory testing is required, appropriate reflex testing will be performed. This will vary from additional protein analysis methods to molecular testing, as needed.
One or more of the following molecular tests may be reflexed:
ATHAL / Alpha-Globin Gene Analysis, Varies;
WASQR / Alpha-Globin Gene Sequencing, Blood;
WBSQR / Beta-Globin Gene Sequencing, Blood;
WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood;
WGSQR / Gamma-Globin Full Gene Sequencing, Varies;
After all test results are finalized, an additional consultative interpretation that summarizes all testing and incorporates subsequent genetic results will be provided.
See Benign Hematology Evaluation Comparison in Special Instructions.
MEVI: Medical Interpretation
HGBCE: Capillary Electrophoresis
HPLC: Cation Exchange/High-Performance Liquid Chromatography (HPLC)
METH, SULF: Spectrophotometry (SP)
METR1: Kinetic Spectrophotometry
IEF: Electrophoresis
HPFH: Flow Cytometry
UNHB: Isopropanol and Heat Stability
MASS: Mass Spectrometry (MS)
MEV0: Medical Interpretation