Test Catalog

Test ID: MEV1    
Methemoglobinemia Evaluation, Blood

Useful For Suggests clinical disorders or settings where the test may be helpful

Diagnosis of methemoglobinemia and sulfhemoglobinemia and possible hereditary (congenital) causes


Differentiation of methemoglobinemia and sulfhemoglobinemia from other causes of cyanosis (eg, congenital heart disease)

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
MEVIMethemoglobinemia InterpretationNoYes
HGBCEHb Variant, A2 and F Quantitation,BYesYes
HPLCHPLC Hb Variant, BNoYes
METHMethemoglobin, BYes, (Order MET)Yes
SULFSulfhemoglobin, BYes, (Order MET)Yes
METR1Cytochrome b5 Reductase, BYesYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
SDEXSickle Solubility, BYesNo
IEFIsoelectric Focusing, BNoNo
MASSHb Variant by Mass Spec, BNoNo
UNHBHb Stability, BNoNo
HPFHHb F Distribution, BNoNo
ATHALAlpha-Globin Gene AnalysisYesNo
WASQRAlpha Globin Gene Sequencing, BYes, (Order WASEQ)No
WBSQRBeta Globin Gene Sequencing, BYes, (Order WBSEQ)No
WBDDRBeta Globin Cluster Locus Del/Dup,BYes, (Order WBDD)No
WGSQRGamma Globin Full Gene SequencingNoNo
MEV0Methemoglobin Summary InterpNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This is a consultative evaluation in which the case will be evaluated at Mayo Clinic Laboratories, the appropriate tests performed at an additional charge, and the results interpreted. This is an evaluation for methemoglobin and sulfhemoglobin levels and possible hereditary causes. Methemoglobin, sulfhemoglobin levels, cytochrome-b5 reductase (methemoglobin reductase) activity, and protein analysis screening for hemoglobin (Hb) variants (capillary electrophoresis, cation exchange high performance liquid chromatography [HPLC] and capillary electrophoresis) will always be performed. If additional hemoglobin variant confirmatory testing is required, appropriate reflex testing will be performed. This will vary from additional protein analysis methods to molecular testing, as needed.


One or more of the following molecular tests may be reflexed:

ATHAL / Alpha-Globin Gene Analysis, Varies;

WASQR / Alpha-Globin Gene Sequencing, Blood;

WBSQR / Beta-Globin Gene Sequencing, Blood;

WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood;

WGSQR / Gamma-Globin Full Gene Sequencing, Varies;


After all test results are finalized, an additional consultative interpretation that summarizes all testing and incorporates subsequent genetic results will be provided.


See Benign Hematology Evaluation Comparison in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

MEVI: Medical Interpretation

HGBCE: Capillary Electrophoresis

HPLC: Cation Exchange/High-Performance Liquid Chromatography (HPLC)

METH, SULF: Spectrophotometry (SP)

METR1: Kinetic Spectrophotometry

IEF: Electrophoresis

HPFH: Flow Cytometry

UNHB: Isopropanol and Heat Stability

MASS: Mass Spectrometry (MS)

MEV0: Medical Interpretation

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Methemoglobinemia Evaluation

Aliases Lists additional common names for a test, as an aid in searching

Cb5r deficiency
Congenital methaemoglobinemia
Congenital methemoglobinemia
cytochrome b5 reductase deficiency
Dominant congenital methemoglobinemia
Hemoglobin M
M Hemoglobins
Methemoglobin Evaluation
NADH cytochrome b5 reductase 3
NADH methemoglobin reductase deficiency
Recessive congenital methemoglobinemia