Web: | mayocliniclabs.com |
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Email: | mcl@mayo.edu |
Telephone: | 800-533-1710 |
International: | +1 855-379-3115 |
Values are valid only on day of printing. |
Evaluation of lifelong or inherited hemolytic anemias, including red cell membrane disorders, unstable or abnormal hemoglobin variants, and red cell enzyme disorders
This evaluation is not suitable for acquired causes of hemolysis.
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
HAEVI | Hemolytic Anemia Interpretation | No | Yes |
HGBCE | Hb Variant, A2 and F Quantitation,B | Yes | Yes |
HPLC | HPLC Hb Variant, B | No | Yes |
UNHB | Hb Stability, B | No | Yes |
FRAGO | Osmotic Fragility | Yes, (Order FRAG) | Yes |
SCTRL | Shipping Control Vial | No | Yes |
BND3 | Band 3 Fluorescence Staining, RBC | No | Yes |
G6PDC | G6PD Enzyme Activity, B | Yes, (Order G6PD1) | Yes |
PKC | PK Enzyme Activity, B | Yes, (Order PK1) | Yes |
GPIC | Glucose Phosphate Isomerase, B | Yes, (Order GPI1) | Yes |
HKC | Hexokinase, B | Yes, (Order HK1) | Yes |
AKC | Adenylate Kinase, B | Yes, (Order AK1) | Yes |
PFKC | Phosphofructokinase, B | Yes, (Order PFK1) | Yes |
PGKC | Phosphoglycerate Kinase, B | Yes, (Order PGK1) | Yes |
TPIC | Triosephosphate Isomerase, B | Yes, (Order TPI1) | Yes |
GSH | Glutathione, B | Yes | Yes |
P5NT | Pyrimidine 5' Nucleotidase, B | Yes | Yes |
PBSM | Morphology Review | No | Yes |
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
SDEX | Sickle Solubility, B | Yes | No |
IEF | Isoelectric Focusing, B | No | No |
MASS | Hb Variant by Mass Spec, B | No | No |
HPFH | Hb F Distribution, B | No | No |
ATHAL | Alpha-Globin Gene Analysis | Yes | No |
WASQR | Alpha Globin Gene Sequencing, B | Yes, (Order WASEQ) | No |
WBSQR | Beta Globin Gene Sequencing, B | Yes, (Order WBSEQ) | No |
WBDDR | Beta Globin Cluster Locus Del/Dup,B | Yes, (Order WBDD) | No |
WGSQR | Gamma Globin Full Gene Sequencing | No | No |
HAEV0 | Hemolytic Anemia Summary Interp | No | No |
This is a consultative evaluation in which the case will be evaluated and appropriate tests performed, at an additional charge, and the results interpreted. If a peripheral blood smear is provided, the morphologic features will be incorporated into the interpretation.
RBC enzymes will always be performed. Capillary electrophoresis, cation exchange high-performance liquid chromatography (HPLC) and hemoglobin stability studies will always be performed. Reflex testing required to positively identify a hemoglobin abnormality may be added as the case requires. Osmotic fragility (OF) and eosin-5-maleimide (EMA) binding band 3 flow cytometry will be performed on all cases. A normal shipping control for OF is necessary to exclude false-positive results due to preanalytic artifact.
The protein and molecular test results will be released separately which may result in incomplete data until all testing has been finalized.
One or more of the following molecular tests may be reflexed on this test:
-ATHAL / Alpha-Globin Gene Analysis, Varies
-WASQR / Alpha-Globin Gene Sequencing, Blood
-WBSQR / Beta-Globin Gene Sequencing, Blood
-WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood
-WGSQR / Gamma-Globin Full Gene Sequencing, Varies
An additional comprehensive consultative interpretation that summarizes all results will be provided after all tests are completed to incorporate results into an overall evaluation.
HAEVI: Medical Interpretation
HGBCE: Capillary Electrophoresis
HPLC: Cation Exchange/High-Performance Liquid Chromatography (HPLC)
UNHB: Isopropanol and Heat Stability
FRAGO: Osmotic Lysis
BND3: Flow Cytometry
G6PDC, PKC, GPIC, HKC, AKC, PFKC, PGKC, TPIC, GSH, P5NT: Kinetic Spectrophotometry (KS)
PBSM: Consultant Review
MASS: Mass Spectrometry (MS)
HPFH: Flow Cytometry
IEF: Isoelectric Focusing
HAEV0: Medical Interpretation