Referred Tests
| Web: | mayocliniclabs.com |
|---|---|
| Email: | mcl@mayo.edu |
| Telephone: | 800-533-1710 |
| International: | +1 855-379-3115 |
| Values are valid only on day of printing. | |
Test ID: HAEV1
Hemolytic Anemia Evaluation, Blood
Useful For 
Suggests clinical disorders or settings where the test may be helpful
Evaluation of lifelong or inherited hemolytic anemias, including red cell membrane disorders, unstable or abnormal hemoglobin variants, and red cell enzyme disorders
This evaluation is not suitable for acquired causes of hemolysis.
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| HAEVI | Hemolytic Anemia Interpretation | No | Yes |
| HGBCE | Hb Variant, A2 and F Quantitation,B | Yes | Yes |
| HPLC | HPLC Hb Variant, B | No | Yes |
| UNHB | Hb Stability, B | No | Yes |
| FRAGO | Osmotic Fragility | Yes, (Order FRAG) | Yes |
| SCTRL | Shipping Control Vial | No | Yes |
| BND3 | Band 3 Fluorescence Staining, RBC | No | Yes |
| G6PDC | G6PD Enzyme Activity, B | Yes, (Order G6PD1) | Yes |
| PKC | PK Enzyme Activity, B | Yes, (Order PK1) | Yes |
| GPIC | Glucose Phosphate Isomerase, B | Yes, (Order GPI1) | Yes |
| HKC | Hexokinase, B | Yes, (Order HK1) | Yes |
| AKC | Adenylate Kinase, B | Yes, (Order AK1) | Yes |
| PFKC | Phosphofructokinase, B | Yes, (Order PFK1) | Yes |
| PGKC | Phosphoglycerate Kinase, B | Yes, (Order PGK1) | Yes |
| TPIC | Triosephosphate Isomerase, B | Yes, (Order TPI1) | Yes |
| GSH | Glutathione, B | Yes | Yes |
| P5NT | Pyrimidine 5' Nucleotidase, B | Yes | Yes |
| PBSM | Morphology Review | No | Yes |
Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SDEX | Sickle Solubility, B | Yes | No |
| IEF | Isoelectric Focusing, B | No | No |
| MASS | Hb Variant by Mass Spec, B | No | No |
| HPFH | Hb F Distribution, B | No | No |
| ATHAL | Alpha-Globin Gene Analysis | Yes | No |
| WASQR | Alpha Globin Gene Sequencing, B | Yes, (Order WASEQ) | No |
| WBSQR | Beta Globin Gene Sequencing, B | Yes, (Order WBSEQ) | No |
| WBDDR | Beta Globin Cluster Locus Del/Dup,B | Yes, (Order WBDD) | No |
| WGSQR | Gamma Globin Full Gene Sequencing | No | No |
| HAEV0 | Hemolytic Anemia Summary Interp | No | No |
Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
This is a consultative evaluation in which the case will be evaluated and appropriate tests performed, at an additional charge, and the results interpreted. If a peripheral blood smear is provided, the morphologic features will be incorporated into the interpretation.
RBC enzymes will always be performed. Capillary electrophoresis, cation exchange high-performance liquid chromatography (HPLC) and hemoglobin stability studies will always be performed. Reflex testing required to positively identify a hemoglobin abnormality may be added as the case requires. Osmotic fragility (OF) and eosin-5-maleimide (EMA) binding band 3 flow cytometry will be performed on all cases. A normal shipping control for OF is necessary to exclude false-positive results due to preanalytic artifact.
The protein and molecular test results will be released separately which may result in incomplete data until all testing has been finalized.
One or more of the following molecular tests may be reflexed on this test:
-ATHAL / Alpha-Globin Gene Analysis, Varies
-WASQR / Alpha-Globin Gene Sequencing, Blood
-WBSQR / Beta-Globin Gene Sequencing, Blood
-WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood
-WGSQR / Gamma-Globin Full Gene Sequencing, Varies
An additional comprehensive consultative interpretation that summarizes all results will be provided after all tests are completed to incorporate results into an overall evaluation.
Special Instructions Library of PDFs including pertinent information and forms related to the test
Method Name A short description of the method used to perform the test
HAEVI: Medical Interpretation
HGBCE: Capillary Electrophoresis
HPLC: Cation Exchange/High-Performance Liquid Chromatography (HPLC)
UNHB: Isopropanol and Heat Stability
FRAGO: Osmotic Lysis
BND3: Flow Cytometry
G6PDC, PKC, GPIC, HKC, AKC, PFKC, PGKC, TPIC, GSH, P5NT: Kinetic Spectrophotometry (KS)
PBSM: Consultant Review
MASS: Mass Spectrometry (MS)
HPFH: Flow Cytometry
IEF: Isoelectric Focusing
HAEV0: Medical Interpretation
NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name Lists a shorter or abbreviated version of the Published Name for a test
Aliases Lists additional common names for a test, as an aid in searching
EMA binding
Eosin
Eosin 5 maleimide
Hemoglobinopathy
Hemolysis
Hemolytic Anemia
Hereditary pyropoikilocytosis
Hereditary spherocytosis
Hyperbilirubinemia
Neonatal anemia
Neonatal hemolysis
Pyruvate kinase deficiency
RBC enzyme
RBC membrane
Unstable hemoglobin