Test Catalog

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Test ID: NTRK    
NTRK Gene Fusion Panel, Tumor

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Useful For Suggests clinical disorders or settings where the test may be helpful

Identifying solid tumors that may respond to targeted therapies by simultaneously assessing for rearrangements involving the NTRK1, NTRK2, and NTRK3 genes resulting in fusion transcripts

 

This test is not useful for hematologic malignancies.

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test uses next-generation sequencing to identify rearrangements (fusions) involving the NTRK1, NTRK2, and NTRK3 genes.

 

The assay was designed to detect the most common NTRK gene fusions and novel gene fusion partners in the targeted gene regions. See NTRK RNA Targeted Gene Fusions table in Special Instructions for details.

 

Of note, this test is performed to evaluate rearrangements (fusions) within solid tumor samples. This test is not intended for use for hematological malignancies.

Highlights

This test evaluates formalin-fixed, paraffin-embedded tumor or cytology slides from patients with advanced solid tumors for rearrangements (fusions) involving the NTRK1, NTRK2, and NTRK3 genes to identify candidates for targeted therapy. Current data suggests that solid tumors with NTRK rearrangements may be sensitive to multikinase inhibitors.

Additional Tests Lists tests that are always performed, at an additional charge, with the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
SLIRVSlide Review in MGNo, (Bill Only)Yes

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

When this test is ordered, slide review will always be performed at an additional charge.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR)-Based Next-Generation Sequencing (NGS)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

NTRK Gene Fusion Panel

Aliases Lists additional common names for a test, as an aid in searching

Next Gen Sequencing Test
NGS
Oncology panel
Tumor panel
NTRK
NTRK1
NTRK2
NTRK3