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Test Catalog

Test ID: MAC1    
Autoimmune Myelopathy Evaluation, Spinal Fluid

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluating patients with suspected autoimmune myelopathy, myelitis, paraneoplastic myelopathy in spinal fluid specimens

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
MCI1Autoimmune Myelopathy Interp, CSFNoYes
AMPHCAmphiphysin Ab, CSFNoYes
AGN1CAnti-Glial Nuclear Ab, Type 1NoYes
ANN1CAnti-Neuronal Nuclear Ab, Type 1NoYes
ANN2CAnti-Neuronal Nuclear Ab, Type 2NoYes
ANN3CAnti-Neuronal Nuclear Ab, Type 3NoYes
CRMWCCRMP-5-IgG Western Blot, CSFYesYes
CRMCCRMP-5-IgG, CSFNoYes
DPPICDPPX Ab IFA, CSFNoYes
GD65CGAD65 Ab Assay, CSFYesYes
GFAICGFAP IFA, CSFNoYes
GL1ICmGluR1 Ab IFA, CSFNoYes
NMOFCNMO/AQP4 FACS, CSFYesYes
PCTRCPurkinje Cell Cytoplasmc Ab Type TrNoYes
PCA1CPurkinje Cell Cytoplasmic Ab Type 1NoYes
PCA2CPurkinje Cell Cytoplasmic Ab Type 2NoYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
AMPCCAMPA-R Ab CBA, CSFNoNo
AMPICAMPA-R Ab IF Titer Assay, CSFNoNo
ABLTCAmphiphysin Western Blot, CSFNoNo
DPPCCDPPX Ab CBA, CSFNoNo
DPPTCDPPX Ab IFA Titer, CSFNoNo
GABCCGABA-B-R Ab CBA, CSFNoNo
GABICGABA-B-R Ab IF Titer Assay, CSFNoNo
GFACCGFAP CBA, CSFNoNo
GFATCGFAP IFA Titer, CSFNoNo
GL1CCmGluR1 Ab CBA, CSFNoNo
GL1TCmGluR1 Ab IFA Titer, CSFNoNo
NMDCCNMDA-R Ab CBA, CSFNoNo
NMDICNMDA-R Ab IF Titer Assay, CSFNoNo
NMOTCNMO/AQP4 FACS Titer, CSFNoNo
WBNCParaneoplas Autoantibody WBlot,CSFNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

If indirect immunofluorescence assay (IFA) (ANN1C, ANN2C, AGN1C, PCA1C, PCA2C, AMPHC) is indeterminate, then WBNC is performed at an additional charge.

 

Western Blot: Native neuronal antigens: performed to confirm neuronal nuclear and cytoplasmic antibody specificities when IF screening is uninterpretable.

 

If IFA patterns suggest amphiphysin antibody, then amphiphysin Western blot is performed at an additional charge.

 

If IFA pattern suggest NMDA-R antibody, then NMDA-R antibody cell-binding assay (CBA) and NMDA-R titer are performed at an additional charge.

 

If IFA pattern suggest AMPA-R antibody, then AMPA-R antibody CBA and AMPA-R titer are performed at an additional charge.

 

If IFA pattern suggest GABA-B-R antibody, then GABA-B-R antibody CBA and GABA-B-R titer are performed at an additional charge.

 

If IFA pattern suggest DPPX antibody, then DPPX antibody CBA and DPPX IFA titer are performed at an additional charge.

 

If IFA pattern suggest mGluR1 antibody, then mGluR1antibody CBA and mGluR1 IFA titer are performed at an additional charge.

 

If IFA pattern suggest GFAP antibody, then GFAP antibody CBA and GFAP IFA titer are performed at an additional charge.

 

If NMO/AQP4-IgG FACS screen assay requires further investigation, then NMO/AQP4-IgG FACS titration assay is performed at an additional charge.

 

See Autoimmune Myelopathy Evaluation Algorithm-Spinal Fluid in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

ANN1C, ANN2C, ANN3C, AGN1C, AMPHC, CRMC, PCA1C, PCA2C, PCTRC, DPPIC, GL1IC, GFAIC, AMPIC, DPPTC, GABIC, GFATC, GL1TC, NMDIC: Indirect Immunofluorescence Assay (IFA)

GD65C: Immunoprecipitation Assay (IPA)

ABLTC, CRMWC, WBNC: Western Blot (WB)

NMOFC, NMOTC: Flow Cytometry (FACS)

AMPCC, DPPCC, GABCC, GL1CC, NMDCC: Cell-binding Assay (CBA)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Autoimmune Myelopathy Eval, CSF

Aliases Lists additional common names for a test, as an aid in searching

Paraneoplastic myelopathy
Neuromyelitis optica
Anti-GFAP