TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: NPM1Q    
Nucleophosmin (NPM1) Mutation Analysis, Varies

Useful For Suggests clinical disorders or settings where the test may be helpful

As a prognostic indicator in patients with newly diagnosed acute myelogenous leukemia with normal karyotype and no FLT3 mutation and as a leukemia-specific marker of minimal residual disease

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

Both DNA and RNA are extracted. The testing starts with a sensitive reverse transcription (RT)-quantitative PCR assay testing for NPM1 mutations form A, B, and D. If the testing is negative or low level (<0.01%), DNA will be used to test NPM1 exon 12 for any insertional events. If form A, B, or D is detected above 0.01% the testing algorithm will stop.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

RNA: Reverse-Transcription Quantitative PCR (RT-qPCR)

DNA: Polymerase Chain Reaction (PCR) with Fragment Analysis by Capillary Gel Electrophoresis

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

NPM1 Mutation Analysis, V

Aliases Lists additional common names for a test, as an aid in searching

NPM1
Nucleophosmin Mutation Analysis