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Test ID: NMS1    
Necrotizing Myopathy Evaluation, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluating patients with suspected necrotizing autoimmune myopathy

Highlights

The utilization of this combinatorial immunoassay provides accuracy and speed in diagnosis of necrotizing autoimmune myopathy (NAM). Early diagnosis facilitates better prognosis through initiation of aggressive immune treatments, typically requiring more than 1 agent, and discontinuation of statin medications. Persons without access to specialty muscle biopsy testing services may be afforded an early diagnosis through application of this testing.

 

Identification of NAM may indicate the presence of a paraneoplastic disorder.

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
NSI1Necrotizing Myopathy Interp, SNoYes
HMGESHMG-CoA ELISA, SNoYes
SRPISSRP IFA Screen, SNoYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
SRPBSSRP Immunoblot, SNoNo
SRPTSSRP IFA Titer, SNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This is a focused algorithmic test designed to achieve high sensitivity for identification of antibodies specific for necrotizing autoimmune myopathy (HMGCOA-IgG and SRP-IgG). This test is unique in the market by having an initial screen for signal recognition particle (SRP) antibodies performed using tissue indirect immunofluorescence, which increases clinical sensitivity as compared to SRP immunoblot methodologies.

 

If indirect immunofluorescence assay (IFA) pattern suggests signal recognition particle (SRP) antibody, SRP IFA titer and SRP54 immunoblot are performed at an additional charge.

Method Name A short description of the method used to perform the test

SRPIS, SRPTS: Indirect Immunofluorescence Assay (IFA)

SRPBS: Immunoblot

HMGES: Enzyme-Linked Immunosorbent Assay (ELISA)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Necrotizing Myopathy Evaluation, S

Aliases Lists additional common names for a test, as an aid in searching

Autoimmune myopathy
Necrotizing myopathy
Immune mediated necrotizing myopathy
Statin induced myopathy
HMGCR
SRP 54
SRP
HMG CoA reductase
SRP54