Web: | mayocliniclabs.com |
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Email: | mcl@mayo.edu |
Telephone: | 800-533-1710 |
International: | +1 855-379-3115 |
Values are valid only on day of printing. |
Evaluating patients with suspected necrotizing autoimmune myopathy
The utilization of this combinatorial immunoassay provides accuracy and speed in diagnosis of necrotizing autoimmune myopathy (NAM). Early diagnosis facilitates better prognosis through initiation of aggressive immune treatments, typically requiring more than 1 agent, and discontinuation of statin medications. Persons without access to specialty muscle biopsy testing services may be afforded an early diagnosis through application of this testing.
Identification of NAM may indicate the presence of a paraneoplastic disorder.
Test ID | Reporting Name | Available Separately | Always Performed |
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NSI1 | Necrotizing Myopathy Interp, S | No | Yes |
HMGCR | HMG-CoA Reductase Ab, S | Yes | Yes |
SRPIS | SRP IFA Screen, S | No | Yes |
Test ID | Reporting Name | Available Separately | Always Performed |
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SRPBS | SRP Immunoblot, S | No | No |
SRPTS | SRP IFA Titer, S | No | No |
This focused algorithmic test is designed to achieve high sensitivity for identification of antibodies specific for necrotizing autoimmune myopathy (HMGCOA-IgG and SRP-IgG). This test is unique in the market by having an initial screen for signal recognition particle (SRP) antibodies performed using tissue indirect immunofluorescence, which increases clinical sensitivity as compared to SRP immunoblot methodologies.
If indirect immunofluorescence assay (IFA) pattern suggests signal recognition particle (SRP) antibody, SRP IFA titer and SRP54 immunoblot are performed at an additional charge.
See Necrotizing Myopathy Evaluation in Special Instructions.
SRPIS, SRPTS: Indirect Immunofluorescence Assay (IFA)
SRPBS: Immunoblot
HMGCR: Chemiluminescent Assay (CIA)
NSI1: Medical Interpretation