Test Catalog

Test ID: ALUPP    
Lupus Anticoagulant Profile, Plasma

Useful For Suggests clinical disorders or settings where the test may be helpful

Confirming or excluding the presence of lupus anticoagulant (LAC), distinguishing LAC from specific coagulation factor inhibitors and nonspecific inhibitors


Investigating a prolonged activated thromboplastin time, especially when combined with other coagulation studies


This test is not useful for the detection of antiphospholipid antibodies that do not affect coagulation tests. We recommend separate testing for serum phospholipid (cardiolipin) antibodies.

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
ALUPILupus Anticoagulant Tech InterpNoYes
PTSCProthrombin Time (PT), PYes, (order PTTP)Yes
APTSCActivated Partial Thrombopl Time, PYes, (order APTTP)Yes
DRV1Dilute Russells Viper Venom Time, PYes, (order DRVI1)Yes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
DIMERD-Dimer, PYes, (order DDITT)No
F8ISCoag Factor VIII Assay Inhib Scrn,PNoNo
FACTVCoag Factor V Assay, PYesNo
F_7Coag Factor VII Assay, PYesNo
TTSCThrombin Time (Bovine), PYesNo
F_9Coag Factor IX Assay, PYesNo
F_10Coag Factor X Assay, PYesNo
F_11Coag Factor XI Assay, PYesNo
F_12Coag Factor XII Assay, PYesNo
F8ACoag Factor VIII Activity Assay, PYesNo
RTSCReptilase Time, PYesNo
F_2Coag Factor II Assay, PYesNo
CLFIBFibrinogen, Clauss, PYes, (order FIBTP)No
SOLFMSoluble Fibrin MonomerNoNo
PNPPlatelet Neutralization ProcedureNoNo
DRV3DRVVT ConfirmationNoNo
ALUPOLupus Anticoagulant InterpNoNo
STACLStaclot LA, PNoNo
RISTRistocetin Cofactor, PNoNo
F5_ISFactor V Inhib ScrnNoNo
VWFMPvon Willebrand Factor Multimer, PYes, ( order VWFMS )No
PTFIBPT-Fibrinogen, PYesNo
VWAGvon Willebrand Factor Ag, PYesNo
VWACTvon Willebrand Factor Activity, PYesNo
CH9Chromogenic FIX, PYesNo
5BETHFV Bethesda Units, PNoNo
F9_ISFactor IX Inhib ScrnNoNo
8BETHFVIII Bethesda Units, PNoNo
9BETHFIX Bethesda Units, PNoNo
CHF8Chromogenic FVIII, PYesNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

Initial testing includes: prothrombin time (PT), activated partial thromboplastin time (APTT), and dilute Russell viper venom time (DRVVT).


If the PT, APTT, and DRVVT are normal, a computer-generated interpretive comment indicating no evidence of a lupus anticoagulant will be provided.


If PT is >13.9 seconds, PT mix will be performed at an additional charge.


If APTT is > or =38 seconds, APTT mix will be performed at an additional charge.


If PT, APTT, or DRVVT are prolonged, thrombin time (TT) will be performed at an additional charge.


If APTT mix is > or =38 seconds and thrombin time is <35.0 seconds (no evidence of heparin), platelet neutralization procedure will be performed at an additional charge.


If DRVVT ratio is > or =1.20, DRVVT mix and DRVVT confirmation will be performed at an additional charge.


If TT is > or =25.0 seconds, reptilase will be performed at an additional charge.


If appropriate, coagulation factor assays, fibrinogen, D-dimer, Staclot LA, and soluble fibrin monomer will be performed to clarify a significant abnormality in the screen test results at an additional charge.


If the factor VIII, IX or V result is below the normal range, the factor inhibitor screen may be performed along with the Bethesda titering assay, if indicated, at an additional charge.


If any test results are abnormal, all results will be reviewed by a coagulation consultant and a Lupus Anticoagulant Interpretation will be provided.


See Lupus Anticoagulant Profile Testing Algorithm in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

PTSC, APTSC, DRV1: Optical Clot-Based

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Lupus Anticoagulant Prof

Aliases Lists additional common names for a test, as an aid in searching

APTT Mixing Studies
Dilute Russell Viper Venom Time (DRVVT)
DRVVT (Dilute Russell Viper Venom Time)
Phospholipid Antibodies
Platelet Neutralization Procedure (PNP Coag Consult)