Test Catalog

Test ID: APROL    
Prolonged Clot Time Profile, Plasma

Useful For Suggests clinical disorders or settings where the test may be helpful

Determining the cause of prolongation of prothrombin time or activated partial thromboplastin time


Screening for prolonged clotting times and determining the presence of factor deficiencies or inhibitor (eg, factor-specific, lupus-like, or the presence of heparin)

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
APRIProlonged Clot Time Prof InterpNoYes
PTSCProthrombin Time (PT), PYes, (order PTTP)Yes
APTSCActivated Partial Thrombopl Time, PYes, (order APTTP)Yes
DRV1Dilute Russells Viper Venom Time, PYes, (order DRVI1)Yes
TTSCThrombin Time (Bovine), PYesYes
CLFIBFibrinogen, Clauss, PYes, (order FIBTP)Yes
DIMERD-Dimer, PYes, (order DDITT)Yes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
GBETHGeneral Factor Bethesda Units, PNoNo
5BETHFV Bethesda Units, PNoNo
8BETHFVIII Bethesda Units, PNoNo
9BETHFIX Bethesda Units, PNoNo
F8ISCoag Factor VIII Assay Inhib Scrn,PNoNo
FACTVCoag Factor V Assay, PYesNo
F_7Coag Factor VII Assay, PYesNo
F_9Coag Factor IX Assay, PYesNo
F_10Coag Factor X Assay, PYesNo
F_11Coag Factor XI Assay, PYesNo
F_12Coag Factor XII Assay, PYesNo
F8ACoag Factor VIII Activity Assay, PYesNo
RTSCReptilase Time, PYesNo
F_2Coag Factor II Assay, PYesNo
PNPPlatelet Neutralization ProcedureNoNo
DRV3DRVVT ConfirmationNoNo
STACLStaclot LA, PNoNo
F5_ISFactor V Inhib ScrnNoNo
F9_ISFactor IX Inhib ScrnNoNo
F2_ISFactor II Inhib ScrnNoNo
F7_ISFactor VII Inhib ScrnNoNo
10_ISFactor X Inhib ScrnNoNo
11_ISFactor XI Inhib ScrnNoNo
PTFIBPT-Fibrinogen, PNoNo
SOLFMSoluble Fibrin MonomerNoNo
CH9Chromogenic FIX, PYesNo
CHF8Chromogenic FVIII, PYesNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

Initial testing includes: prothrombin time (PT), activated partial thromboplastin time (APTT), dilute Russell viper venom time (DRVVT), thrombin time (bovine), fibrinogen, D-dimer, and prolonged clot time interpretation.


If PT is >13.9 seconds, then PT mix will be performed at an additional charge.

If APTT is > or =38 seconds, then APTT mix will be performed at an additional charge.

If APTT mix is > or =38 seconds and thrombin time is <35.0 seconds (no evidence of heparin), then platelet neutralization procedure will be performed at an additional charge.

If DRVVT ratio is > or =1.20, then DRVVT mix and DRVVT confirmation will be performed at an additional charge.

If thrombin time is > or =25.0 seconds, then reptilase time will be performed at an additional charge.

If fibrinogen is <150 mg/dL, or clinically indicated, then PT-fibrinogen will be performed at an additional charge.

If D-dimer is >500 ng/mL FEU, then soluble fibrin monomer will be performed at an additional charge.

If PT, APTT, or DRVVT is prolonged, then coagulation factor assays may be performed at an additional charge.

If factor assay result is below the normal range, the appropriate factor inhibitor screen may be performed along with the Bethesda titering assay, at an additional charge, if inhibitor screen is positive.

If appropriate, Staclot lupus anticoagulant (LA) will be performed at an additional charge to clarify significant abnormalities in the screen test results.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

PTSC, APTSC, DRV1, TTSC,: Optical Clot-Based

CLFIB: Clauss

DIMER: Latex Immunoassay (LIA)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Prolonged Clot Time Prof

Aliases Lists additional common names for a test, as an aid in searching

Prolonged Clot Time Profile