Test ID: APROL    
Prolonged Clot Time Profile, Plasma

Determining the cause of prolongation of prothrombin time or activated partial thromboplastin time

Screening for prolonged clotting times and determining the presence of factor deficiencies or inhibitor (eg, factor-specific, lupus-like, or the presence of heparin)

Initial testing includes: prothrombin time (PT), activated partial thromboplastin time (APTT), dilute Russell viper venom time (DRVVT), thrombin time (bovine), fibrinogen, D-dimer, and prolonged clot time interpretation.

If PT is >13.9 seconds, then PT mix will be performed at an additional charge.

If APTT is > or =38 seconds, then APTT mix will be performed at an additional charge.

If APTT mix is > or =38 seconds and thrombin time is <35.0 seconds (no evidence of heparin), then platelet neutralization procedure will be performed at an additional charge.

If DRVVT ratio is > or =1.20, then DRVVT mix and DRVVT confirmation will be performed at an additional charge.

If thrombin time is > or =25.0 seconds, then reptilase time will be performed at an additional charge.

If fibrinogen is <150 mg/dL, or clinically indicated, then PT-fibrinogen will be performed at an additional charge.

If D-dimer is >500 ng/mL FEU, then soluble fibrin monomer will be performed at an additional charge.

If PT, APTT, or DRVVT is prolonged, then coagulation factor assays may be performed at an additional charge.

If factor assay result is below the normal range, the appropriate factor inhibitor screen may be performed along with the Bethesda titering assay, at an additional charge, if inhibitor screen is positive.

If appropriate, Staclot lupus anticoagulant (LA) will be performed at an additional charge to clarify significant abnormalities in the screen test results.

• Coagulation Guidelines for Specimen Handling and Processing
• Coagulation Patient Information
• Coagulation Profile Comparison

PTSC, APTSC, DRV1, TTSC,: Optical Clot-Based

CLFIB: Clauss

DIMER: Latex Immunoassay (LIA)