Test Id : CCBF
Cell Count and Differential, Body Fluid
Useful For
Suggests clinical disorders or settings where the test may be helpful
Aiding in the diagnosis of joint disease, systemic disease, inflammation, malignancy, infection, and trauma, using body fluid specimens
Profile Information
A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test Id | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| CCBF_ | Cell Count and Differential, BF | No | Yes |
| CRSF | Morphologic Review, BF | No | Yes |
Reflex Tests
Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.
| Test Id | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| LCMS | Leukemia/Lymphoma, Phenotype | Yes | No |
| CYTNG | Cytology Non-GYN | Yes | No |
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
When abnormal cytologic features are present, the laboratory may reflex to a miscellaneous cytology test. Fee codes for that test vary depending on the review process.
Method Name
A short description of the method used to perform the test
CCBF, CCBF_, CRSF: Automated or Manual Cell Count/Cytocentrifugation followed by Manual Differential and Morphology Review
CYTNG: Light Microscopy
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
When abnormal cytologic features are present, the laboratory may reflex to a miscellaneous cytology test. Fee codes for that test vary depending on the review process.
Specimen Type
Describes the specimen type validated for testing
Body Fluid
Ordering Guidance
For spinal fluid specimens, order CCCF / Cell Count and Differential, Spinal Fluid.
For bronchoalveolar lavage specimens, order BALCC / Cell Count and Differential, Bronchoalveolar Lavage.
Shipping Instructions
Specimens must arrive within 24 hours of collection.
Necessary Information
Indicate specimen source
ORDER QUESTIONS AND ANSWERS
| Question ID | Description | Answers |
|---|---|---|
| FLD2 | Fluid Type |
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
For Local Accounts Only
Sources: Synovial, pleural, peritoneal, pericardial
Container/Tube:
Preferred: Body fluid container
Acceptable: Tube containing EDTA or heparin
Specimen Volume: 1 mL
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.
0.7 mL
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
| Gross hemolysis | OK |
| Clotted Nasal fluid Sputum Amniotic fluid | Reject |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Body Fluid | Ambient (preferred) | 24 hours | |
| Refrigerated | 24 hours |
Useful For
Suggests clinical disorders or settings where the test may be helpful
Aiding in the diagnosis of joint disease, systemic disease, inflammation, malignancy, infection, and trauma, using body fluid specimens
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
When abnormal cytologic features are present, the laboratory may reflex to a miscellaneous cytology test. Fee codes for that test vary depending on the review process.
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Body fluids, other than the commonly analyzed urine and blood, include synovial, pleural, peritoneal, and pericardial fluids. These fluids may be present in increased volumes and may contain increased numbers of normal and abnormal cells in a variety of disease states.
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Total Nucleated Cells
Synovial fluid: <150/mcL
Peritoneal/pleural/pericardial fluid: <500/mcL
Neutrophils
Synovial fluid: <25%
Peritoneal/pleural/pericardial fluid: <25%
Lymphocytes
Synovial fluid: <75%
Monocytes/Macrophages
Synovial fluid: < or =70%
Interpretation
Provides information to assist in interpretation of the test results
Trauma and hemorrhage may result in increased red and white blood cells; red blood cells predominate. White blood cells are increased in inflammatory and infectious processes:
-Neutrophils predominate in bacterial infections
-Lymphocytes predominate in viral infections
-Macrophages may be increased in inflammatory and infectious processes
-Eosinophils may be increased in parasitic or fungal infections
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
No significant cautionary statements
Clinical Reference
Recommendations for in-depth reading of a clinical nature
1. Kjeldsberg C, Knight J. Body Fluids: Laboratory examination of cerebrospinal, seminal, serous and synovial fluids. American Society of Clinical Pathologists; 1993
2. Dyken PR, Shirley S, Trefz J, El Gammel T. Comparison of cyto-centrifugation and sedimentation techniques for CSF cyto-morphology. Acta Cytol. 1980;24(2)167-170
3. Sheth KV. Cerebrospinal and body fluid cell morphology through a hematologist's microscope, workshop presented at the ASCP-CAP Joint Spring Meeting; 03/1981
4. Schumacher AH, Reginato A. Atlas of Synovial Fluid Analysis and Crystal Identification. Lea and Febiger; 1991
5. Hussong JW, Kjeldsberg CR. Kjeldsberg's Body Fluid Analysis. ASCP Press; 2015
Method Description
Describes how the test is performed and provides a method-specific reference
The cells are applied to a glass slide by cytocentrifugation. Wright-Giemsa-stained slides are examined by light microscopy and a differential is performed. Total nucleated cell count is determined using an automated hematology analyzer or a microscopic counting chamber.(Instruction manual: Automated Hematology Analyzer XN Series [XN-9000/XN-9100] [North American Edition], Code No. CP266599. Sysmex; Revision, 03/2017)
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Monday through Sunday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees :
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their account representative. For assistance, contact Customer Service.
Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
CPT codes are provided by the performing laboratory.
89051-Cell count with differential count
88184-if applicable
88185-if applicable
88187-if applicable
88188-if applicable
88189-if applicable
88104-if applicable
88108-if applicable
88112-if applicable
88161-if applicable
88162-if applicable
88305-if applicable
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| CCBF | Cell Count and Differential, BF | 34557-9 |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| FLD2 | Fluid Type | 14725-6 |
| APP2 | Gross Appearance | 9335-1 |
| TOT12 | Total Nucleated Cells | 74689-1 |
| RBC1 | Erythrocytes | 26455-6 |
| CMT37 | Comment | 48767-8 |
| NE_BF | Neutrophils | 26513-2 |
| LY_BF | Lymphocytes | 11031-2 |
| MM_BF | Monocytes/Macrophages | 30437-8 |
| EO_BF | Eosinophils | 26452-3 |
| BA_BF | Basophils | 28543-7 |
| OTH1 | Other Cells | In Process |
| CMT3 | Diff Comments | 59466-3 |
| DCCBF | Download CCBF | No LOINC Needed |
| OTH11 | Other Cells Are: | In Process |
| CMT81 | Comment | 48767-8 |
| REV81 | Reviewed by: | 18771-6 |