Test Catalog

Test ID: COGBM    
Chromosome Analysis, Hematologic Disorders, Children's Oncology Group Enrollment Testing, Bone Marrow

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluation of pediatric bone marrow specimens for chromosomal abnormalities associated with hematologic malignancies for diagnostic and prognostic purposes in patients being considered for enrollment in Children’s Oncology Group clinical trials and research protocols


Cytogenetic testing is important for the diagnostic and prognostic classification of pediatric neoplasia and it is a critical element for the enrollment of children into clinical trials affiliated with the Children's Oncology Group (COG). For over 25 years the Mayo Clinic Genomics Laboratory has served as one of a select number of laboratories in the United States approved by the COG for the conventional chromosome analysis and fluorescence in situ hybridization (FISH) analysis of pediatric bone marrow, peripheral blood, and tissue specimens. All enrollment-required elements of cytogenetic testing will be electronically submitted by the Mayo Clinic Genomics Laboratory within the guidelines of COG.

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
ML20CCOG Metaphases, 1-19 No, (Bill Only)No
M25CCOG Metaphases, 20-25No, (Bill Only)No
MG25CCOG Metaphases, >25No, (Bill Only)No
_STACAg-Nor/CBL StainNo, (Bill Only)No

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test includes a charge for cell culture of fresh specimens and professional interpretation of results. Analysis charges will be incurred for total work performed, and generally include 2 banded karyograms and the analysis of 20 metaphase cells. If no metaphase cells are available for analysis, no analysis charges will be incurred. If additional analysis work is required, additional charges may be incurred.


If this test is ordered and the laboratory is informed that the patient is not on a Children's Oncology Group (COG) protocol, this test will be canceled and automatically reordered by the laboratory as the corollary assay, CHRBM / Chromosome Analysis, Hematologic Disorders, Bone Marrow.


The following algorithms are available in Special Instructions:

-Laboratory Screening Tests for Suspected Multiple Myeloma

-Myeloproliferative Neoplasm: A Diagnostic Approach to Bone Marrow Evaluation

-Myelodysplastic Syndrome: Guideline to Diagnosis and Follow-up

-Acute Promyelocytic Leukemia: Guideline to Diagnosis and Follow-up

-B-Lymphoblastic Leukemia/Lymphoma Algorithm

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Cell Culture without Mitogens followed by Chromosome Analysis

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

COG-Chromosomes, Hematologic, BM

Aliases Lists additional common names for a test, as an aid in searching

Karyotype, Bone Marrow
Children's Oncology Group