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Test ID: FINA    
NAbFeron (IFNB-1) Neutralizing Antibody Test

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Useful For Suggests clinical disorders or settings where the test may be helpful

Detection of antibodies to interferon-B-1

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Final report has been sent to the referring laboratory.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

The present of neutralizing antibodies to interferon beta, especially in persistently high titers, may be associated with reduction in the clinical effectiveness of interferon beta therapy (1). Although the measurement of Nabs can add to the clinical and imaging information used to assess the efficacy of interferon beta therapy, these results should be interpreted in the context of clinical presentation and medical history (2, 3).

 

Although rare, false positive or false negative results may occur. All results should be interpreted in the context of clinical findings, relevant history, and other laboratory data.

Clinical Reference Recommendations for in-depth reading of a clinical nature

  1. Goodin, DS, et al. (2007) Neurology 68:977-984 (PMID: 17389300)
  2. Polman, CH, et al.(2010) Lancet Neurol 9:740-50 (PMID: 20610349)
  3. Creeke, Pl, et al. (2013) Ther Adv Neurol Disord 6:3-17 (PMID: 23277789)