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Test Catalog

Test ID: FSERO    
SeroNeg RAdx3 Profile

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

SeroNeg RAdx3 is a diagnostic and prognostic panel for Rheumatoid Arthritis designed to complement traditional RF and Anti-CCP testing. This profile, consisting of 14-3-3 eta protein, Anti -CEP-1 Ab and Anti-Sa Ab, enhances the diagnosis of established or early RA (in individuals seronegative for RF and Anti-CCP Ab) and also helps predict disease severity. Decrease in 14-3-3eta and/or Anti-Sa Ab with treatment is associated with less radiographic progression. The presence of Anti-CEP1 and Anti-CCP Antibodies suggests the imminent progression of pre-clinical RA into clinical RA

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Interpretation for:

14.3.3 ETA, Rheum. Arthritis:

Reference Range: <0.20 ng/mL

Negative:                <0.20 ng/mL

Weak Positive:       0.20-0.39 ng/mL

Moderate Positive: 0.40-0.79 ng/mL

Strong Positive:     >0.79 ng/mL

 

Interpretation for:

Anti-CEP-1 Ab, IgG and Anti-Sa Ab, IgG:

Reference Range: <20

Negative: <20 units

Weak Positive: 20-39 units

Moderate Positive: 40-80 units

Strong Positive: >80 units