Test Catalog

Test ID: TCRGD    
T-Cell Receptor Delta Immunostain, Technical Component Only

Useful For Suggests clinical disorders or settings where the test may be helpful

Classification of lymphomas

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

T-cell receptor delta expression is seen in a small proportion of total T cells. Recognition of T-cell lymphomas that are derived from the delta T-cell subset is important as they often have a more aggressive clinical behavior. Normal tonsils show scattered cells staining in the interfollicular regions.

Interpretation Provides information to assist in interpretation of the test results

This test includes only technical performance of the stain (no pathologist interpretation is performed). Mayo Clinic cannot provide an interpretation of tech only stains outside the context of a pathology consultation. If an interpretation is needed, refer to PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case. All material associated with the case is required. Additional specific stains may be requested as part of the pathology consultation, and will be performed as necessary at the discretion of the Mayo pathologist.


The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut within 6 weeks.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Roullet M, Gheith SMF, Mauger J, et al: Percentage of gamma-delta T cells in panniculitis by paraffin immunohistochemical analysis. Am J Clin Pathol 2009;131:820-826

2. Willemze R, Jansen PM, Cerroni L, et al: Subcutaneous panniculitis-like T-Cell lymphoma: Definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 38 cases. Blood 2008;111:838-845

3. Vega F, Medeiros LJ, Gaulard P: Hepatosplenic and other gammadelta T-cell lymphomas. Am J Clin Pathol 2007;127:869-880