Test Catalog

Test ID: IGDI    
IgD Immunostain, Technical Component Only

Useful For Suggests clinical disorders or settings where the test may be helpful

Aids in the classification of lymphomas and multiple myeloma

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

The immunoglobulin molecules (antibodies) function as the surface receptors for antigens for B lymphocytes and as the secretory products of plasma cells forming the humoral arm of the immune system. IgD represents one of the immunoglobulin heavy chain types. Immunoreactivity is a specific marker for B lymphocytes and plasma cells; it is expressed normally on mantle zone lymphocytes. Diagnostically, staining for immunoglobulin heavy chains can aid in the diagnosis and classification of small B cell malignant lymphomas and multiple myeloma.

Interpretation Provides information to assist in interpretation of the test results

This test does not include pathologist interpretation, only technical performance of the stain. If interpretation is required order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.


The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request; call 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut within 6 weeks.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Dai X, Wu YJ, Jia XY, et al: Immunoglobulin D (IgD) and IgD receptor expression in diffuse large B-cell lymphoma. Hematology. 2019 Dec;24(1):544-551. doi: 10.1080/16078454.2019.1642553

2. Royal V, Quint P, Leblanc M, et al: IgD heavy-chain deposition disease: detection by laser microdissection and mass spectrometry. J Am Soc Nephrol. 2015 Apr;26(4):784-90. doi: 10.1681/ASN.2014050481.

3. Sorigue M, Junca J, Gassiot S, Milla F, Mate JL, Navarro JT: A case of CD138-/CD19+/CD4+ IgD plasma cell leukemia. Cytometry B Clin Cytom. 2014 Mar 22. doi: 10.1002/cytob.21173