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Test ID: HNF1B    
Hepatocyte Nuclear Factor 1Beta Immunostain, Technical Component Only

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Useful For Suggests clinical disorders or settings where the test may be helpful

Diagnosis of ovarian clear cell carcinoma and endometrial clear cell carcinoma

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Hepatocyte nuclear factor-1beta (HNF-1beta) is a transcription factor that regulates the transcription of the TCF2 gene into proteins. HNF-1beta has been shown to be upregulated in ovarian clear cell carcinoma.

Interpretation Provides information to assist in interpretation of the test results

This test does not include pathologist interpretation, only technical performance of the stain. If interpretation is required order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.

 

The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request; call 855-516-8404.

 

Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen dependent. Best practice is for paraffin sections to be cut within 6 weeks.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. DeLair D, Han G, Irving JA, et al: HNF-1beta in ovarian carcinomas with serous and clear cell change. Int J Gynecol Pathol. 2013; 32(6):541-546. doi: 10.1097/PGP.0b013e318273fd07

2. Fadare O, Zhao C, Khabele D, et al: Comparative analysis of napsin A, alpha-methylacyl-coenzyme A racemase (AMACR, P504S), and hepatocyte nuclear factor 1 beta as diagnostic markers of ovarian clear cell carcinoma: an immunohistochemical study of 279 ovarian tumours. Pathology. 2015; 47(2):105-111. doi: 10.1097/PAT.0000000000000223

3. Li Q, Zeng X, Cheng X, et al: Diagnostic value of dual detection of hepatocyte nuclear factor 1 beta (HNF-1beta) and napsin A for diagnosing ovarian clear cell carcinoma. Int J Clin Exp Pathol. 2015;8(7):8305-8310