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Values are valid only on day of printing. |
Aids in the diagnosis of ovarian clear cell carcinoma and endometrial clear cell carcinoma
For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).
Hepatocyte nuclear factor-1beta (HNF-1beta) is a transcription factor that regulates the transcription of the TCF2 gene into proteins. HNF-1beta has been shown to be upregulated in ovarian clear cell carcinoma.
This test includes only technical performance of the stain (no pathologist interpretation is performed). Mayo Clinic cannot provide an interpretation of tech only stains outside the context of a pathology consultation. If an interpretation is needed, refer to PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case. All material associated with the case is required. Additional specific stains may be requested as part of the pathology consultation, and will be performed as necessary at the discretion of the Mayo pathologist.
The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.
Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut within 6 weeks.
1. DeLair D, Oliva E, Kobel M, et al: Morphologic spectrum of immunohistochemically characterized clear cell
carcinoma of the ovary: a study of 155 cases. Am J Surg Pathol 2011;35:36-44
2. Kobel M, Kalloger SE, Carrick J, et al: A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary. Am J Surg Pathol 2009;33:14-21
3. Yamamoto S, Tsuda H, Aida S, et al: Immunohistochemical detection of hepatocyte nuclear factor 1beta in ovarian and endometrial clear-cell adenocarcinomas and nonneoplastic endometrium Hum Pathol 2007 Jul;38(7):1074-1080
4. Kato N, Sasou S, Motoyama T: Expression of hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell
tumors and endometriosis of the ovary. Mod Pathol 2006 Jan;19(1):83-89