Web: | mayocliniclabs.com |
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Email: | mcl@mayo.edu |
Telephone: | 800-533-1710 |
International: | +1 855-379-3115 |
Values are valid only on day of printing. |
Aiding in the diagnosis of hematological malignancies and identification of cells of the macrophage/dendritic cell lineage within tissues
CD11c is a member of the leukocyte specific integrin family, involved in adherence to activated endothelial cells and complement-mediated phagocytosis. CD11c is normally expressed on histiocytes and monocytes, and weakly expressed on granulocytes. CD11c is also expressed on certain B cell neoplasms, including hairy cell leukemia and splenic marginal zone lymphoma.
This test does not include pathologist interpretation; only technical performance of the stain. If interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.
The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.
Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut within 6 weeks.
1. Wu J, Wu H, An J, Ballantyne CM, Cyster JG: Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity. Proc Natl Acad Sci USA. 2018; 115(26), 6786-6791
2. Troussard X, Cornet E: Hairy cell leukemia 2018: Update on diagnosis, risk-stratification, and treatment. Am J Hematol. 2017; 92(12), 1382-1390
3. Devin J, Kassambara A, Bruyer A, Moreaux J, Bret C: Phenotypic characterization of diffuse large B-cell lymphoma cells and prognostic impact. J Clin Med. 2019; 8(7), 1074