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Test ID: CD11C    
CD11c Immunostain, Technical Component Only

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Useful For Suggests clinical disorders or settings where the test may be helpful

Aiding in the diagnosis of hematological malignancies and identification of cells of the macrophage/dendritic cell lineage within tissues

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

CD11c is a member of the leukocyte specific integrin family, involved in adherence to activated endothelial cells and complement-mediated phagocytosis. CD11c is normally expressed on histiocytes and monocytes, and weakly expressed on granulocytes. CD11c is also expressed on certain B cell neoplasms, including hairy cell leukemia and splenic marginal zone lymphoma.

Interpretation Provides information to assist in interpretation of the test results

This test does not include pathologist interpretation; only technical performance of the stain. If interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.

 

The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.

 

Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut within 6 weeks.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Wu J, Wu H, An J, Ballantyne CM, Cyster JG: Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity. Proc Natl Acad Sci USA. 2018; 115(26), 6786-6791

2. Troussard X, Cornet E: Hairy cell leukemia 2018: Update on diagnosis, risk-stratification, and treatment. Am J Hematol. 2017; 92(12), 1382-1390

3. Devin J, Kassambara A, Bruyer A, Moreaux J, Bret C: Phenotypic characterization of diffuse large B-cell lymphoma cells and prognostic impact. J Clin Med. 2019; 8(7), 1074